@gmgmlab.bsky.social
Great collaboration from Alexandre Smirnov's group with Vikram Panse's team placing uS11 isoaspartylase Fap7 in the ribosome assembly pathway: www.biorxiv.org/content/10.6...
A nucleolar assembly module integrates an ancestral isoaspartylase to safeguard ribosome biogenesis
Eukaryotes inherited the core ribosome biogenesis apparatus from archaea. However, nucleocytoplasmic compartmentalisation and expansion to >200 assembly factors created the challenge of integrating th...
www.biorxiv.org
September 8, 2026 at 12:21 PM
Great collaboration from Alexandre Smirnov's group with Vikram Panse's team placing uS11 isoaspartylase Fap7 in the ribosome assembly pathway: www.biorxiv.org/content/10.6...
Reposted
Congrats to the authors of the two teams who discovered these enzymes! Ours here. 5/
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11
Isoaspartate (isoAsp) formation is typically viewed as a "molecular clock" through nonenzymatic degradation of aspartate or asparagine during protein aging. Here we report a nearly universal enzymatic...
www.biorxiv.org
August 27, 2026 at 2:26 PM
Congrats to the authors of the two teams who discovered these enzymes! Ours here. 5/
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Check out the new preprint from Alexandre Smirnov's and Nicolas Leulliot's labs about the ultraconserved mechanisms of ribosome isoaspartylation: www.biorxiv.org/content/10.6...
And an independently done work on the same subject from Jamie Cate's and Mitchell's labs: www.biorxiv.org/content/10.6...
And an independently done work on the same subject from Jamie Cate's and Mitchell's labs: www.biorxiv.org/content/10.6...
www.biorxiv.org
August 28, 2026 at 7:52 AM
Check out the new preprint from Alexandre Smirnov's and Nicolas Leulliot's labs about the ultraconserved mechanisms of ribosome isoaspartylation: www.biorxiv.org/content/10.6...
And an independently done work on the same subject from Jamie Cate's and Mitchell's labs: www.biorxiv.org/content/10.6...
And an independently done work on the same subject from Jamie Cate's and Mitchell's labs: www.biorxiv.org/content/10.6...