Jack Kucinski
@jackkucinski.bsky.social
Ph.D. Candidate at The Ohio State University and Nationwide Children’s Hospital
Pinned
Jack Kucinski
@jackkucinski.bsky.social
· Jul 23
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory
mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1
oncoprotein function...
www.cell.com
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Reposted by Jack Kucinski
Grateful to the @americancancersoc.bsky.social for awarding me with the postdoctoral fellowship. Thanks to my mentor @kendalllab.bsky.social and other collaborators for supporting me and I'm excited to contribute to pediatric cancer research and improving patient outcomes in infants and children.
April 9, 2026 at 4:04 PM
Grateful to the @americancancersoc.bsky.social for awarding me with the postdoctoral fellowship. Thanks to my mentor @kendalllab.bsky.social and other collaborators for supporting me and I'm excited to contribute to pediatric cancer research and improving patient outcomes in infants and children.
🥳 Our preprint is LIVE 🥳 Huge thanks to Lex Tallan and the Stanton lab for another fantastic collaboration! Here, we use zebrafish and MNase-based methodology to show that PAX3::FOXO1 and PAX7::FOXO1 have divergent capabilities for interacting with repressive chromatin states and nucleosomal DNA.
Comparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcoma https://www.biorxiv.org/content/10.64898/2026.02.18.706582v1
February 23, 2026 at 6:35 PM
🥳 Our preprint is LIVE 🥳 Huge thanks to Lex Tallan and the Stanton lab for another fantastic collaboration! Here, we use zebrafish and MNase-based methodology to show that PAX3::FOXO1 and PAX7::FOXO1 have divergent capabilities for interacting with repressive chromatin states and nucleosomal DNA.
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory
mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1
oncoprotein function...
www.cell.com
July 23, 2025 at 3:14 PM
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...