Jonathan Dragwidge
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jm-dragwidge.bsky.social
Jonathan Dragwidge
@jm-dragwidge.bsky.social
82 followers 120 following 0 posts
Plant cell biologist, interested in endocytosis, autophagy, plant-virus interactions, and all things microscopy 🌱🔬🦠
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Reposted by Jonathan Dragwidge
sciezgin.bsky.social
New paper out: Plasma membrane order maps functional diversity in immune cells
We showed how biophysical state of the membranes correlates with the activity of immune cells such as migration and killing.
www.nature.com/articles/s41...
Plasma membrane order maps functional diversity in immune cells - Nature Chemical Biology
Cells undergo membrane remodeling in response to the environment to perform specific functions. Now, a cytometry-based method with immune cell biomarker analysis captures variations in plasma membrane...
www.nature.com
September 17, 2026 at 7:14 AM
Reposted by Jonathan Dragwidge
plantubiquitin.bsky.social
Latest paper from my lab !! New insight into transporter endocytosis in plants using TurboID. Proud of liza-pellegrin.bsky.social for the great work and @julnev.bsky.social for driving this.
doi.org/10.1111/nph....
@lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
<fc>TurboID</fc>‐based proteomic profiling reveals proxitome of the <fc>IRT1</fc> metal transporter and new insight into <fc>IRT1</fc> endocytosis
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1-inter....
doi.org
September 14, 2026 at 6:39 AM
Reposted by Jonathan Dragwidge
proteinmagnus.bsky.social
How does linear motifs drive dephosphorylation - and does it matter where and how strong the motifs are?

These are the question Evi answers in her brand new pre-print:

www.biorxiv.org/content/10.6...
September 13, 2026 at 6:46 PM
Reposted by Jonathan Dragwidge
ishier.bsky.social
Membrane Trafficking Seminar Series 2026 fall season is here!

An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all!

Save the dates and join us for fun science and discussions.

Details at felixcampelo.wixsite.com/membranetraf...
September 7, 2026 at 5:16 PM
Reposted by Jonathan Dragwidge
marischuster.bsky.social
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬

If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵

Please RT/share!
September 7, 2026 at 9:46 AM
Reposted by Jonathan Dragwidge
mareikejordan.bsky.social
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social

www.biorxiv.org/content/10.6...
September 4, 2026 at 9:45 AM
Reposted by Jonathan Dragwidge
jennyrussinova.bsky.social
We had the privilege to host Gautam Dey @gautamdey.bsky.social (EMBL Heidelberg, Germany) as a keynote speaker at @enper2026.bsky.social. Fantastic talk, beautiful microscopy!
August 27, 2026 at 12:35 PM
Reposted by Jonathan Dragwidge
yohannboutte.bsky.social
Second one of the DivFuse consortium from Samantha Moulin, PhD student in @mc-caillaud.bsky.social group, PI4,5P2 and TRAPPII interplay during cytokinesis.
August 27, 2026 at 8:50 AM
Reposted by Jonathan Dragwidge
yohannboutte.bsky.social
First talk from Yutaro Shimizu, post-doc in my team, at the @enper2026.bsky.social meeting from our DivFuse consortium in collaboration with Farhah Assaad at TUM and @mc-caillaud.bsky.social at ENS Lyon, the project addresses how cell plate insertion is coordinated in a spatio-temporal manner.
August 27, 2026 at 8:40 AM
Reposted by Jonathan Dragwidge
thevirusmc.bsky.social
Out now! ➡️ Going viral – Plant selective autophagy swiping left and right on viral infections. We review how viruses and selective autophagy interact and propose that multiple parallel pathways collectively shape infection outcomes. Kudos to @jcmuede.bsky.social at @mpi-mp-potsdam.bsky.social.
July 22, 2026 at 12:08 PM
Reposted by Jonathan Dragwidge
matesf.bsky.social
We are convinced we have solved the mechanism of rapid auxin response in roots. @plantmorpho.bsky.social www.biorxiv.org/content/10.6...
Hormone-dependent receptor docking controls calcium channel activity in plants
The phytohormone auxin is a central coordinator of plant growth and development. Besides its canonical effect on gene transcription[1][1],[2][2], auxin triggers an ultra-rapid calcium ion influx that ...
www.biorxiv.org
July 15, 2026 at 2:23 PM
Reposted by Jonathan Dragwidge
schumacherlab.bsky.social
Thx @johnrubinstein.bsky.social for the excellent collaboration and for promoting Nadja @nadwu.bsky.social to postdoc ;-)!
johnrubinstein.bsky.social John Rubinstein @johnrubinstein.bsky.social · Jul 4
New preprint! Karin Schumacher's postdoc Nadja used our SidK approach to purify Arabidopsis V-ATPase & Mariia Khamina determined its structure. The structure shows unique plant V-ATPase features and that TLDc proteins (here OXR5) bind V-ATPase in all eukaryotes. 🌱
tinyurl.com/mw9xaszk
Overall structure of Arabidopsis V-ATPase. (A) SDS-PAGE of purified V-ATPase. (B) Composite map of Arabidopsis V-ATPase in rotational state 1. (C) Atomic model of Arabidopsis V-ATPase in rotational state 1. (D) Cross sections of the V1 and VO regions in three rotational states. (E) Conformations of subunit H in V-ATPase structures of Arabidopsis V-ATPase (top) and the citrus fruit (bottom) V-ATPase. V-ATPase from the TGN/EE interacts with the TLDc protein OXR5. (A) Composite map of Arabidopsis V-ATPase in rotational state 1 bound to OXR5 (green density). (B) AlphaFold3 model (left) and domain organisation (right) of OXR5. (C) VHA-a1-mNG is localized at the TGN/EE. OXR5-PmScarlet-I shows partial overlap with VHA-a1-mNG at the TGN/EE. Scale bar, 20 µm. Root tip elongation zone of 5-day-old Arabidopsis seedlings were analyzed by confocal laser scanning microscopy. (D-H) Atomic model of Arabidopsis V-ATPase interactions with OXR5.
July 7, 2026 at 9:58 AM
Reposted by Jonathan Dragwidge
alvaroferfer.bsky.social
With a bit of delay, but my latest work on engineering a sensor for plant proteolysis was published online in The Plant Cell (1/5).
June 25, 2026 at 1:45 PM
Reposted by Jonathan Dragwidge
cnrsbiologie.bsky.social
#ResultatScientifique🔎| Autophagie végétale : identification de deux enzymes essentielles au recyclage des déchets cellulaires

✍️ Amélie Bernard
📕 @natcomms.nature.com
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social @lbm-bordeaux.bsky.social
L’autophagie chez les plantes : découverte des deux enzymes clés pour dégrader et recycler les déchets cellulaires
Comment les plantes libèrent-elles le contenu des vésicules autophagiques une fois celles-ci arrivées dans la vacuole ?
buff.ly
June 15, 2026 at 2:03 PM
Reposted by Jonathan Dragwidge
ottlab.bsky.social
Happy to share our newest preprint. We developed guidelines and analysis workflows for FLIM Imaging in plants. Multiplexing with spectrally overlapping fluorophores in plants is now possible. Have a look. Any feedback is more than welcome.
www.biorxiv.org/content/10.6...
June 12, 2026 at 2:16 PM
Reposted by Jonathan Dragwidge
ajcellbio.bsky.social
This session will showcase some really state-of-the-art imaging techniques to look at cellular architecture (@sventruckenbrodt.bsky.social) and live, contact free biomechanics (@laurabacete.bsky.social)!

Sign up below!

#expansionmicroscopy #brillouin #plants 🌱🔬
May 26, 2026 at 5:20 PM
Reposted by Jonathan Dragwidge
suaybuestuen.bsky.social
What a fantastic study by @thevirusmc.bsky.social, @plantophagy.bsky.social & co. how autophagy fine-tunes immune responses during viral infection by degrading EDS1!

Stay tuned - we will soon lift the mystery around why autophagy acts as a "pro-death" pathway during bacterial infection ☠️ 🤓
Selective autophagy fine-tunes plant immunity to promote cell survival during viral infection
RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...
www.science.org
May 28, 2026 at 6:51 PM
Reposted by Jonathan Dragwidge
jorissprakel.bsky.social
Chemical probes + imaging can reveal spatiotemporal patterns of a wide range of physico-chemical features in plants, without the need for genetic access.

We reviewed what tools exist and how they can be used & engineered.

Chemistry meets plant cell biology!

www.annualreviews.org/content/jour...
Chemical Probes for Functional Plant Imaging
The advent of spatial and quantitative biology has led to immense advances in understanding the complex inner workings of plants, down to the molecular scale. Functional imaging of live plants, which ...
www.annualreviews.org
May 21, 2026 at 6:02 AM
Reposted by Jonathan Dragwidge
briggsgroup.bsky.social
COPII at the ERES in-situ from @dr-downes.bsky.social in the Zanetti lab @giuliazanetti.bsky.social: doi.org/10.1038/s415...
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells - Nature Cell Biology
Downes et al. use in situ cryo-electron tomography and super-resolution fluorescence microscopy to define ER exit site architecture in unperturbed human cells. They visualize ribosome-exclusion zones ...
doi.org
May 21, 2026 at 7:21 AM
Reposted by Jonathan Dragwidge
briggsgroup.bsky.social
The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social
Architecture of clathrin-independent AP3:ARF1-coated carriers
AP3 generates clathrin-free carriers on endosomes by organizing via ARF1 dimers into elongated membrane-deforming arrays.
www.science.org
May 18, 2026 at 11:24 AM
Reposted by Jonathan Dragwidge
ckirchhelle.bsky.social
Incredibly proud of this paper showing how plants couple vesicle delivery and phragmoplast expansion during division. This project started in the lab of the great and late Ian Moore, and it was a joy to finish it with @liamelliottplants.bsky.social et al!

link.springer.com/article/10.1...
A Rab/Kinesin-12/kinase module couples vesicle delivery and phragmoplast dynamics during plant cell cytokinesis - The EMBO Journal
Cytokinesis is a key process in the development of multicellular organisms, through both formative and proliferative divisions. In land plants, successful cytokinesis requires precise targeting of Gol...
link.springer.com
May 15, 2026 at 10:11 PM
Reposted by Jonathan Dragwidge
ajcellbio.bsky.social
If you ever wondered about the history and current state of plant Clathrin-mediated endocytosis....here is a review just for you!

onlinelibrary.wiley.com/doi/10.1111/...

Was really fun to write this with awesome co-authors!

⚽️🌱🔬
Clathrin‐Mediated Endocytosis in Plants: Historical to Modern Advances
Ultrastructural studies by Bonnett and Newcomb in 1966 revealed the existence of coated vesicles budding from the plant cell plasma membrane. This review introduces this discovery and early questions...
onlinelibrary.wiley.com
May 15, 2026 at 11:05 AM
Reposted by Jonathan Dragwidge
suaybuestuen.bsky.social
See my new post on our homepage ✍️

The journey to our newest publication on how plants cope with proteotoxic stress ♻️

www.cell.com/molecular-ce...

From Doubt to Discovery: A 15-Year Journey into Proteostasis, Pathogens, and Persistence
From Doubt to Discovery: A 15-Year Journey into Proteostasis, Pathogens, and Persistence
More than 15 years ago, during my PhD, we stumbled upon something unexpected. In a yeast two-hybrid screen, bacterial effector proteins from Xanthomonas and Pseudomonas interacted with a subunit of…
theustunlab.com
May 6, 2026 at 7:47 AM
Reposted by Jonathan Dragwidge
moritznowack.bsky.social
Out now in @natplants.nature.com: A cell type-specific antagonism of autophagy and age-induced programmed cell death controls root hair life span www.nature.com/articles/s41..., back to back with another story on root hair-specific autophagy by @plantophagy.bsky.social www.nature.com/articles/s41...
May 6, 2026 at 9:05 AM