Lack Laboratory
@lacklab.bsky.social
Exploring androgen receptor biology to develop innovative therapies against prostate cancer. #ProstateCancer #CancerResearch #AndrogenReceptors #nuclear receptors
https://lacklab.org
https://lacklab.org
Reposted by Lack Laboratory
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
www.science.org
April 10, 2026 at 6:30 AM
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
🧵 New paper from Lack Laboratory in PNAS:
HOXB13 has been studied for years as an AR coregulator.
But what happens when the AR is gone?
We found that HOXB13 doesn’t disappear but instead rewires its activity. See below for more details: (1/6)
www.pnas.org/doi/10.1073/...
HOXB13 has been studied for years as an AR coregulator.
But what happens when the AR is gone?
We found that HOXB13 doesn’t disappear but instead rewires its activity. See below for more details: (1/6)
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 23, 2025 at 12:27 PM
🧵 New paper from Lack Laboratory in PNAS:
HOXB13 has been studied for years as an AR coregulator.
But what happens when the AR is gone?
We found that HOXB13 doesn’t disappear but instead rewires its activity. See below for more details: (1/6)
www.pnas.org/doi/10.1073/...
HOXB13 has been studied for years as an AR coregulator.
But what happens when the AR is gone?
We found that HOXB13 doesn’t disappear but instead rewires its activity. See below for more details: (1/6)
www.pnas.org/doi/10.1073/...
Reposted by Lack Laboratory
🚨We are recruiting two PhD students 🚨
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
December 17, 2025 at 7:53 AM
🚨We are recruiting two PhD students 🚨
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
🧬 Funded PhD Studentships – Vancouver Prostate Centre (UBC) 🧬
Join our team to investigate transcriptional regulation in prostate cancer. Two fully funded PhD positions available.
Interested: please send a CV + short expression of interest.
#CancerResearch #PhD #UBC
Join our team to investigate transcriptional regulation in prostate cancer. Two fully funded PhD positions available.
Interested: please send a CV + short expression of interest.
#CancerResearch #PhD #UBC
December 15, 2025 at 4:09 PM
🧬 Funded PhD Studentships – Vancouver Prostate Centre (UBC) 🧬
Join our team to investigate transcriptional regulation in prostate cancer. Two fully funded PhD positions available.
Interested: please send a CV + short expression of interest.
#CancerResearch #PhD #UBC
Join our team to investigate transcriptional regulation in prostate cancer. Two fully funded PhD positions available.
Interested: please send a CV + short expression of interest.
#CancerResearch #PhD #UBC
Passionate about single-cell method development? 🔬 Join our lab as a Postdoctoral Fellow at @UBC and help uncover androgen receptor enhancer mechanisms in prostate cancer.
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ayjobs.com
rb.gy
August 19, 2025 at 1:32 PM
Passionate about single-cell method development? 🔬 Join our lab as a Postdoctoral Fellow at @UBC and help uncover androgen receptor enhancer mechanisms in prostate cancer.
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Looking forward to attending the UK Hormone Dependent Cancer Conference this November!
I'll be sharing some of our latest work alongside a great lineup of researchers. If you're interested in hormone-driven cancers, come join us.
More details here: bit.ly/SfEHDC25
I'll be sharing some of our latest work alongside a great lineup of researchers. If you're interested in hormone-driven cancers, come join us.
More details here: bit.ly/SfEHDC25
Hormone Dependent Cancer 2025 | Society for Endocrinology
The Hormone Dependent Cancer Conference 2025 will take place in York on 17-18 November 2025.
The first event of its kind from the Society will enable attendees to explore the latest developments in h...
bit.ly
July 15, 2025 at 3:32 PM
Looking forward to attending the UK Hormone Dependent Cancer Conference this November!
I'll be sharing some of our latest work alongside a great lineup of researchers. If you're interested in hormone-driven cancers, come join us.
More details here: bit.ly/SfEHDC25
I'll be sharing some of our latest work alongside a great lineup of researchers. If you're interested in hormone-driven cancers, come join us.
More details here: bit.ly/SfEHDC25