@laurentboyer.bsky.social
Reposted
Finally out! The largest ever multiomics COPD study. 1.5M lung cells. 141 individuals. snRNAseq, spatial, blood proteomics reveal shifting cell states & biomarkers across COPD stages, disease endotypes.
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease - Nature Genetics
This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell compositio...
www.nature.com
January 24, 2026 at 8:00 PM
Finally out! The largest ever multiomics COPD study. 1.5M lung cells. 141 individuals. snRNAseq, spatial, blood proteomics reveal shifting cell states & biomarkers across COPD stages, disease endotypes.
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Reposted
The Normal Aging Lung Cell Atlas is finally out!!!
ScRNASeq reveals that lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing greatest changes in gene expression, somatic mutations burden, transcriptional entropy
www.nature.com/articles/s41...
ScRNASeq reveals that lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing greatest changes in gene expression, somatic mutations burden, transcriptional entropy
www.nature.com/articles/s41...
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy - Nature Communications
The changing cellular, transcriptional, and genomic landscape of human lung aging can be characterized using single-cell RNA sequencing. Here, the authors show that lung aging is cell-type dyssynchron...
www.nature.com
January 25, 2026 at 6:54 PM
The Normal Aging Lung Cell Atlas is finally out!!!
ScRNASeq reveals that lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing greatest changes in gene expression, somatic mutations burden, transcriptional entropy
www.nature.com/articles/s41...
ScRNASeq reveals that lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing greatest changes in gene expression, somatic mutations burden, transcriptional entropy
www.nature.com/articles/s41...
Reposted
New study has uncovered how cellular senescence contributes to development of chronic obstructive pulmonary disease, offering insights for new therapeutic strategies
Read the article here: www.atsjournals.org/doi/full/10....
youtu.be/GoaMStPubUM
@atscommunity.bsky.social #medsky
Read the article here: www.atsjournals.org/doi/full/10....
youtu.be/GoaMStPubUM
@atscommunity.bsky.social #medsky
Understanding Role of Cellular Senescence in Chronic Obstructive Pulmonary Disease
YouTube video by American Thoracic Society
youtu.be
January 15, 2026 at 9:00 PM
New study has uncovered how cellular senescence contributes to development of chronic obstructive pulmonary disease, offering insights for new therapeutic strategies
Read the article here: www.atsjournals.org/doi/full/10....
youtu.be/GoaMStPubUM
@atscommunity.bsky.social #medsky
Read the article here: www.atsjournals.org/doi/full/10....
youtu.be/GoaMStPubUM
@atscommunity.bsky.social #medsky
Reposted
From Liver Insights to Lung Innovations: FGF21 and Idiopathic Pulmonary Fibrosis
Ghanem et al demonstrate a mechanistic role for FGF21/KLB in the regulation of mitochondrial apoptotic pathways in alveolar epithelial cells in IPF
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ews4f7e
Ghanem et al demonstrate a mechanistic role for FGF21/KLB in the regulation of mitochondrial apoptotic pathways in alveolar epithelial cells in IPF
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ews4f7e
March 26, 2025 at 8:45 PM
From Liver Insights to Lung Innovations: FGF21 and Idiopathic Pulmonary Fibrosis
Ghanem et al demonstrate a mechanistic role for FGF21/KLB in the regulation of mitochondrial apoptotic pathways in alveolar epithelial cells in IPF
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ews4f7e
Ghanem et al demonstrate a mechanistic role for FGF21/KLB in the regulation of mitochondrial apoptotic pathways in alveolar epithelial cells in IPF
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/4ews4f7e
Reposted
FGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/m5ctz4wn
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/m5ctz4wn
March 26, 2025 at 8:57 PM
FGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/m5ctz4wn
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/m5ctz4wn
Reposted
Reposted
More than happy to have been awarded an #ERCCoG grant for my KINTSUGI project ✨! We will be studying mechanisms of lung resilience to atmospheric pollution.
I cannot thank enough all the people who have helped to build the project, the @univbordeaux.bsky.social, the IUF and @inserm.bsky.social🙏.
I cannot thank enough all the people who have helped to build the project, the @univbordeaux.bsky.social, the IUF and @inserm.bsky.social🙏.
. @dupinisabelle.bsky.social, prof. en physiologie explore les mécanismes qui permettent au poumon de s'adapter et de se réparer face à la pollution. Son projet "Kintsugi" ambitionne d’allier biologie, philosophie et modélisation pour déchiffrer ce processus fascinant www.u-bordeaux.fr/ac...
December 5, 2024 at 5:30 PM
More than happy to have been awarded an #ERCCoG grant for my KINTSUGI project ✨! We will be studying mechanisms of lung resilience to atmospheric pollution.
I cannot thank enough all the people who have helped to build the project, the @univbordeaux.bsky.social, the IUF and @inserm.bsky.social🙏.
I cannot thank enough all the people who have helped to build the project, the @univbordeaux.bsky.social, the IUF and @inserm.bsky.social🙏.