Luc-Alban Vuillemenot
@lavuillemenot.bsky.social
Postdoc @ Alexis Barr Lab (@imperialcollegeldn.bsky.social, @mrc-lms.bsky.social). Cell cycle control, Systems Biology, Cancer, Aging, Metabolism, Computer vision.
Reposted by Luc-Alban Vuillemenot
A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment.
Understanding these hideouts could lead to new drug targets🧬
@mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
Understanding these hideouts could lead to new drug targets🧬
@mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
Scientists map dormant cancer cells' hideouts, opening new targets for treatment
Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumours and identified distinct neigh...
lms.mrc.ac.uk
July 30, 2026 at 4:17 PM
A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment.
Understanding these hideouts could lead to new drug targets🧬
@mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
Understanding these hideouts could lead to new drug targets🧬
@mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
Reposted by Luc-Alban Vuillemenot
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...
www.biorxiv.org
December 3, 2025 at 4:03 PM
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Reposted by Luc-Alban Vuillemenot
New Year, new paper! (Ok, it actually came out just before Christmas but who was working then?!)
Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU
Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
British Journal of Cancer - Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
rdcu.be
January 2, 2025 at 11:34 AM
New Year, new paper! (Ok, it actually came out just before Christmas but who was working then?!)
Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU
Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU