Pinned
Nicholas Tay
@malayoman.bsky.social
· Apr 4
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...
www.science.org
Excited to share that our protein editing method from the Muir Lab is now published in @science.org
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
Reposted by Nicholas Tay
Nearly a decade ago, Niyi and I began exploring photocatalysis to map protein spatial organization. Our new @nature.com
paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines.
www.nature.com/articles/s41...
paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines.
www.nature.com/articles/s41...
Proximity-guided graph learning reveals tumour-associated proximity antigens - Nature
A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances ...
www.nature.com
September 10, 2026 at 8:54 PM
Nearly a decade ago, Niyi and I began exploring photocatalysis to map protein spatial organization. Our new @nature.com
paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines.
www.nature.com/articles/s41...
paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines.
www.nature.com/articles/s41...
Reposted by Nicholas Tay
Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. www.science.org/doi/10.1126/... #NBThighlight
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...
www.science.org
April 4, 2025 at 1:17 PM
Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. www.science.org/doi/10.1126/... #NBThighlight
Excited to share that our protein editing method from the Muir Lab is now published in @science.org
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...
www.science.org
April 4, 2025 at 12:35 AM
Excited to share that our protein editing method from the Muir Lab is now published in @science.org
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
Reposted by Nicholas Tay
If you’re checking out the GRS, apply to our big sibling conference, the 2025 Bioorganic Chemistry GRC! The speaker list this year is insane 🤩 the GRC is truly my favorite conference to attend and I can’t wait to see everyone there next summer!
Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up:
grc.org/bioorganic-c...
grc.org/bioorganic-c...
November 16, 2024 at 10:33 PM
If you’re checking out the GRS, apply to our big sibling conference, the 2025 Bioorganic Chemistry GRC! The speaker list this year is insane 🤩 the GRC is truly my favorite conference to attend and I can’t wait to see everyone there next summer!