Maria Kalyva
@mariakalyva.bsky.social
Computational biologist, working in Mcgranahan lab, @UCL, before @EMBL. I mostly care about long reads, mutations and isoforms. 🧬
Bandlamudi et al. analyze 50,000+ tumors across 64 cancer types from the MSK-50K cohort — identifying 164 novel hotspots, revealing tissue-dependent driver behaviour, and highlighting barriers to neoantigen-directed immunotherapy. We wrote a preview to put this work into context:
Online Now: Redefining cancer drivers with tissue-specific context
Redefining cancer drivers with tissue-specific context
In this issue of Cancer Cell, Bandlamudi and colleagues analyze over 50,000 tumors spanning 64 cancer types, revealing how tissue context dictates the prevalence and evolutionary timing of somatic driver alterations. Their findings underscore the need to move away from a purely gene-centric view of oncology toward a context-aware framework.
dlvr.it
April 8, 2026 at 9:43 AM
Bandlamudi et al. analyze 50,000+ tumors across 64 cancer types from the MSK-50K cohort — identifying 164 novel hotspots, revealing tissue-dependent driver behaviour, and highlighting barriers to neoantigen-directed immunotherapy. We wrote a preview to put this work into context:
Thank you to the organizers for the invitation to speak and for a fantastic few days of science at Windermere. I am leaving with lots of new ideas and appreciation for this community. #RNAUK26
@takanobutagawa.bsky.social @alenashkumatava.bsky.social
@takanobutagawa.bsky.social @alenashkumatava.bsky.social
February 2, 2026 at 11:21 AM
Thank you to the organizers for the invitation to speak and for a fantastic few days of science at Windermere. I am leaving with lots of new ideas and appreciation for this community. #RNAUK26
@takanobutagawa.bsky.social @alenashkumatava.bsky.social
@takanobutagawa.bsky.social @alenashkumatava.bsky.social
Reposted by Maria Kalyva
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
September 24, 2025 at 10:38 PM
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...