Mark Ashe
@markashe.bsky.social
Biologist at Manchester Uni interested in translation/ mRNA plus saddo Wolves fan and rubbish wildlife photographer
Reposted by Mark Ashe
'The University of Manchester is seeking alternative funding sources to keep scientific work at Jodrell Bank going after hearing that lost UK Research and Innovation funding would not be restored despite interventions by the prime minister.'
Manchester seeks alternative Jodrell funds despite Burnham pledge
University exploring new revenue streams to continue important scientific research at site, as astronomers remain concerned about the future of facility
www.timeshighereducation.com
October 9, 2026 at 7:30 AM
'The University of Manchester is seeking alternative funding sources to keep scientific work at Jodrell Bank going after hearing that lost UK Research and Innovation funding would not be restored despite interventions by the prime minister.'
Mission accomplished in Boat of Garten recently
February 26, 2026 at 7:11 AM
Mission accomplished in Boat of Garten recently
Just got back after #yeast2025 - exhausted but a great conference with great science and organisation
July 25, 2025 at 8:58 PM
Just got back after #yeast2025 - exhausted but a great conference with great science and organisation
Reposted by Mark Ashe
Great RNA/ protein fate seminar yesterday given by Adrien Rousseau from University of Dundee on proteasome assembly mechnnisms
May 2, 2025 at 6:50 AM
Great RNA/ protein fate seminar yesterday given by Adrien Rousseau from University of Dundee on proteasome assembly mechnnisms
This paper looks amazing! Probably a very very naive question - but why is a polyA polymerase specific for mRNAs encoding secreted proteins? Are these mRNAs particularly prone to deadenylation?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines - Nature
Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and tran...
www.nature.com
April 17, 2025 at 6:48 PM
This paper looks amazing! Probably a very very naive question - but why is a polyA polymerase specific for mRNAs encoding secreted proteins? Are these mRNAs particularly prone to deadenylation?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Saw this beauty in Daisy Nook park today
February 1, 2025 at 3:44 PM
Saw this beauty in Daisy Nook park today
Cool review - very nicely written!!- Fits well with our random thoughts on the connections between RBPs and the glycolysis/ respiration metabolic transition in yeast.
Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI
doi.org/10.1038/s443...
doi.org/10.1038/s443...
RNA-binding proteins as versatile metabolic regulators - npj Metabolic Health and Disease
npj Metabolic Health and Disease - RNA-binding proteins as versatile metabolic regulators
doi.org
January 14, 2025 at 5:52 PM
Cool review - very nicely written!!- Fits well with our random thoughts on the connections between RBPs and the glycolysis/ respiration metabolic transition in yeast.
Mixed emotions when a key member of the group moves to pastures new- Good luck in the NZ adventure Rob!!
December 19, 2024 at 8:04 PM
Mixed emotions when a key member of the group moves to pastures new- Good luck in the NZ adventure Rob!!
Anyone fancy doing a phd on oxidative modification of mRNA?
Pari is just starting her lab and she’s dedicated, intelligent and lovely to work with- honest!!
www.findaphd.com/phds/project...
Pari is just starting her lab and she’s dedicated, intelligent and lovely to work with- honest!!
www.findaphd.com/phds/project...
BBSRC NWD: Exploitation of RNA modification for optimal protein expression under stress conditions at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Exploitation of RNA modification for optimal protein expression under stress conditions at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
December 19, 2024 at 8:00 PM
Anyone fancy doing a phd on oxidative modification of mRNA?
Pari is just starting her lab and she’s dedicated, intelligent and lovely to work with- honest!!
www.findaphd.com/phds/project...
Pari is just starting her lab and she’s dedicated, intelligent and lovely to work with- honest!!
www.findaphd.com/phds/project...
Oh joy! I’ve been tinselled
December 3, 2024 at 11:17 AM
Oh joy! I’ve been tinselled
Great idea! - also could be adapted for purifying the target RNA with much less background
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
November 30, 2024 at 9:18 PM
Great idea! - also could be adapted for purifying the target RNA with much less background
Wow - how cool is this!!!
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
November 28, 2024 at 11:59 AM
Wow - how cool is this!!!
Much excitement in chez Ashe - we had a visitor last night! Urban badgers who knew!!
November 6, 2024 at 7:00 PM
Much excitement in chez Ashe - we had a visitor last night! Urban badgers who knew!!