Martin Mikl
@martinmikl.bsky.social
PI (Senior Lecturer/Asst. Prof.), University of Haifa.
Gene regulation, RNA biology, systems biology, cell biology.
Gene regulation, RNA biology, systems biology, cell biology.
Pinned
Martin Mikl
@martinmikl.bsky.social
· Aug 4
Promoter identity shapes splicing outcomes and fidelity - Nature Communications
Using massively parallel reporter assays of mini-genes with variable promoters and cassette exon sequences, the authors show that promoter identity is a major determinant of alternative splicing, shap...
doi.org
Happy to share this story from our lab out in @natcomms.nature.com where we used massively parallel reporter assays to elucidate the effect of promoter identity on alternative splicing. Special credits go to the first author, my soon-to-graduate PhD student Shaked Shanas.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
New paper from our lab, now out in @commsbio.nature.com: Can we make Shiftless a more effective inhibitor of programmed ribosomal frameshifting (PRF)?
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Functional dissection of Shiftless identifies features enhancing ribosomal frameshifting inhibition - Communications Biology
The authors develop a high-throughput platform to quantify programmed ribosomal frameshifting inhibition by large libraries of protein variants. They identify residues essential for the activity of th...
doi.org
September 17, 2026 at 2:47 PM
New paper from our lab, now out in @commsbio.nature.com: Can we make Shiftless a more effective inhibitor of programmed ribosomal frameshifting (PRF)?
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Reposted by Martin Mikl
Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️
August 12, 2026 at 3:42 PM
Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️
Happy to share this story from our lab out in @natcomms.nature.com where we used massively parallel reporter assays to elucidate the effect of promoter identity on alternative splicing. Special credits go to the first author, my soon-to-graduate PhD student Shaked Shanas.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Promoter identity shapes splicing outcomes and fidelity - Nature Communications
Using massively parallel reporter assays of mini-genes with variable promoters and cassette exon sequences, the authors show that promoter identity is a major determinant of alternative splicing, shap...
doi.org
August 4, 2026 at 9:36 AM
Happy to share this story from our lab out in @natcomms.nature.com where we used massively parallel reporter assays to elucidate the effect of promoter identity on alternative splicing. Special credits go to the first author, my soon-to-graduate PhD student Shaked Shanas.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Martin Mikl
My lab at ETHZ has an opening for a postdoc in spatial risk stratification: www.jobs.ethz.ch/job/view/JOP.... Please apply if suitable, or RT, thanks!
Postdoctoral Researcher - Spatial Omics for Colorectal Cancer Risk Stratification
www.jobs.ethz.ch
August 19, 2025 at 3:28 PM
My lab at ETHZ has an opening for a postdoc in spatial risk stratification: www.jobs.ethz.ch/job/view/JOP.... Please apply if suitable, or RT, thanks!
Reposted by Martin Mikl
I have one open PhD position. Maybe one of the last PhD positions in the lab as I'm planning changes in what we do and how we will do it some five years from now. I'm offering freedom (pun intended), respect, an interesting project, and a good full time contract w. health insurance.
🧬Unravel the evolution of RNA cutting enzymes in @svobodalab.bsky.social
Learn more about the project 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity #prague
Learn more about the project 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity #prague
January 24, 2025 at 8:56 AM
I have one open PhD position. Maybe one of the last PhD positions in the lab as I'm planning changes in what we do and how we will do it some five years from now. I'm offering freedom (pun intended), respect, an interesting project, and a good full time contract w. health insurance.
Reposted by Martin Mikl
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
www.biorxiv.org
November 27, 2024 at 1:38 PM
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Martin Mikl
A pair of graphs I think about a lot. On the topic of pooled CRISPR screens, the left is "replicate correlation" when simply examining the abundance of guide RNAs, i.e. log-normalized read counts. On the right is taking those same data and subtracting from a common starting point, i.e. pDNA.
November 26, 2024 at 3:31 PM
A pair of graphs I think about a lot. On the topic of pooled CRISPR screens, the left is "replicate correlation" when simply examining the abundance of guide RNAs, i.e. log-normalized read counts. On the right is taking those same data and subtracting from a common starting point, i.e. pDNA.