Matthew Burke
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mattburkemd.bsky.social
Matthew Burke
@mattburkemd.bsky.social
Cognitive Neurologist specializing in Neuropsychiatry at Sunnybrook Health Sciences Centre and the University of Toronto
Thanks for sharing Tim 🙏
April 21, 2026 at 8:01 PM
Reposted by Matthew Burke
Second article focuses on the critical issue of detecting/measuring & appraising placebo in trials

Such a massively important (and complex/fascinating) issue in evidence based medicine that’s still so poorly understood

www.sciencedirect.com/science/arti...
Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry
Placebo effects are among the greatest paradoxes in medical research. Although more data on placebos are available from placebo-controlled trials than…
www.sciencedirect.com
April 16, 2026 at 6:13 AM
Reposted by Matthew Burke
Putting placebo effects in a new light
www.sciencedirect.com
April 16, 2026 at 6:50 AM
Our findings will be shared by Dr. Saarah Haque in the Clinical Platform Presentation session this afternoon at the American Neuropsychiatric Association Annual Meeting in Montreal 2/2

@uoftmedicine.bsky.social
March 12, 2025 at 2:57 PM
Collaboration with our great Sunnybrook multi-specialty Trauma team (ICU, Neuro, Psych and Rehab) and @silverberglab.bsky.social
January 3, 2025 at 8:42 PM
Finally, many of these themes have been articulated by @alancarson15.bsky.social @jonstoneneuro.bsky.social @lauramcw.bsky.social and others...but have not yet made their way to mainstream concussion care. We hope this practical framework helps bridge gaps and increase crosstalk between disciplines
December 10, 2024 at 9:13 PM
when they may actually benefit most from an opposite approach utilizing CBT-based principles and aiming to reduce symptom preoccupation, redirect attention, reframe beliefs, and encourage graded exposure to avoided activities (reducing fear avoidance behaviors).
December 10, 2024 at 9:13 PM
We try to summarize the implications of these issues through a case vignette in the Online Supplement. We discuss how a patient with FND triggered by head injury may be harmed by some standard PCS/PPCS rehabilitation protocols that encourage close monitoring of symptoms etc
December 10, 2024 at 9:13 PM
We also hone in on Curve 3 - synergism between concussion and FND presenting a potential ‘two hit’ hypothesis to the same/vulnerable brain circuits. We had to squish this into the figure legend due to word limits...but certainly worth a read.
December 10, 2024 at 9:13 PM