#microsky
New preprint from the lab!
Widespread immune systems protect bacteria against conjugative plasmids
www.biorxiv.org/content/10.6...
Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab.
🧵⬇️

Great piece and cover @science.org about how our field is uncovering the evolutionary and mechanistic connections between bacterial and eukaryotic immunity !
www.science.org/content/article/ancient-wars-between-microbes-gave-us-key-immune-defenses

Here's the link to the preprint:
www.biorxiv.org/content/10.6...
Looking forward to discussing the story with folks at #SISB2026 this week! 🦠

That's a wrap on three days of incredible science at #SISB2026! Special thanks to @rockefeller.edu for hosting us on their beautiful campus, to our speakers and poster presenters, and most of all to this community that never fails to inspire. Can't wait for #SISB2027 🫶

🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

So great to see the work of the lab being brillantly presented at conferences across 🇮🇹🍦🍝, @matthieu-haudiquet.bsky.social on Evolution and Mechanism of Lamassu in FEMS, Milan and Ernest Mordret on LLM for prediction of antiphage systems in GRC Evolutionary Genomics,Tuscany.
Check out their work 👇

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

It was an honor for my lab and myself to host the meeting on the Immune Systems of Bacteria. Such a high from all the incredible science and sharing with scientists from the whole world the greatness of Paris in the spring.
Vive la science, et vive Paris!

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

Out in NAR, AntiDefenseFinder & our "systematic" analysis of inhibitors of antiphage systems wt Bondy-Denomy lab led by @ftesson.bsky.social and E. Huiting.

Not so "systematic" as very few known, fun stuff on MGE, antidefense islands and cool phages exaptations!

academic.oup.com/nar/advance-...