Ranganath Muniyappa
@muniyappar.bsky.social
Senior Clinician and Endocrinologist NIDDK
with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
Reposted by Ranganath Muniyappa
Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
July 25, 2026 at 2:33 PM
Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
Reposted by Ranganath Muniyappa
I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
On the computability of biological machines
In the book Natural Theology (1802), the English philosopher and theologian William
Paley argued that the complexity of an organism, similar to that of a watch, implied
the handiwork of a designer.1 H...
www.thelancet.com
April 17, 2026 at 9:08 AM
I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts
A new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment.
www.statnews.com
April 2, 2026 at 6:41 PM
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com
Guideline communication raises concerns on Lancet obesity report
April 2, 2026 at 6:40 PM
Guideline communication raises concerns on Lancet obesity report
New Endocrine Society
guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy.
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy.
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework
Abstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio
academic.oup.com
April 2, 2026 at 6:38 PM
New Endocrine Society
guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy.
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy.
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
Reposted by Ranganath Muniyappa
no quarter can or should be given to hold this evil to account
Breaking: IPost has obtained CCTV footage showing a Border Patrol van dropping off Nurul Shah Alam at a closed Tim Hortons last Thursday.
Shah Alam, nearly-blind & unable to enter the shop, then wandered the city for days. He was found dead Tuesday.
www.investigativepost.org/2026/02/26/t...
Shah Alam, nearly-blind & unable to enter the shop, then wandered the city for days. He was found dead Tuesday.
www.investigativepost.org/2026/02/26/t...
February 27, 2026 at 1:32 AM
no quarter can or should be given to hold this evil to account
Reposted by Ranganath Muniyappa
I feel like reading the news should now come with a trigger warning.
The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization.
And these are only the cases we know about…
The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization.
And these are only the cases we know about…
February 27, 2026 at 2:03 AM
I feel like reading the news should now come with a trigger warning.
The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization.
And these are only the cases we know about…
The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization.
And these are only the cases we know about…
Reposted by Ranganath Muniyappa
Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...
GPR75 in glutamatergic neurons regulates body weight
Wyler, S.C. et al. identify a critical neuronal population that is required for GPR75
to exert its obesogenic effects using targeted deletion and reactivation of Gpr75
in glutamatergic neurons.
www.cell.com
February 21, 2026 at 1:00 PM
Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...
Reposted by Ranganath Muniyappa
The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...
The Danger Of Superhuman AI Is Not What You Think | NOEMA
The rhetoric over “superhuman” AI implicitly erases what’s most important about being human.
www.noemamag.com
February 21, 2026 at 10:20 AM
The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...
This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values.
Katyal: "I was able to go to court - the son of immigrants-- & say on behalf of small businesses, 'Hey, this president is acting illegally.' I was able to present my case, have them ask really hard questions, & at the end of it they voted & we won. That is something extraordinary about this country"
February 20, 2026 at 9:37 PM
This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values.
Reposted by Ranganath Muniyappa
The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...
www.sandiegouniontribune.com/2026/02/19/s...
February 20, 2026 at 8:29 PM
The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...
www.sandiegouniontribune.com/2026/02/19/s...
Reposted by Ranganath Muniyappa
My quote of the day
A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us.
John Steinbeck
A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us.
John Steinbeck
February 20, 2026 at 10:48 AM
My quote of the day
A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us.
John Steinbeck
A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us.
John Steinbeck
Reposted by Ranganath Muniyappa
Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes."
February 20, 2026 at 3:34 PM
Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes."
Reposted by Ranganath Muniyappa
well said - indeed a peer review system in crisis
hard to find someone to review
burden of review
duplication and waste
misuse/corruption of peer review
www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News
#NephSky
hard to find someone to review
burden of review
duplication and waste
misuse/corruption of peer review
www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News
#NephSky
February 20, 2026 at 2:27 PM
well said - indeed a peer review system in crisis
hard to find someone to review
burden of review
duplication and waste
misuse/corruption of peer review
www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News
#NephSky
hard to find someone to review
burden of review
duplication and waste
misuse/corruption of peer review
www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News
#NephSky
Reposted by Ranganath Muniyappa
this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me
it's a sin to walk past, never mind to exploit the victim further
it's a sin to walk past, never mind to exploit the victim further
![The Parable of the Good Samaritan
25 On one occasion an expert in the law stood up to test Jesus. “Teacher,” he asked, “what must I do to inherit eternal life?”
26 “What is written in the Law?” he replied. “How do you read it?”
27 He answered, “‘Love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind’[a]; and, ‘Love your neighbor as yourself.’[b]”
28 “You have answered correctly,” Jesus replied. “Do this and you will live.”
29 But he wanted to justify himself, so he asked Jesus, “And who is my neighbor?”
30 In reply Jesus said: “A man was going down from Jerusalem to Jericho, when he was attacked by robbers. They stripped him of his clothes, beat him and went away, leaving him half dead. 31 A priest happened to be going down the same road, and when he saw the man, he passed by on the other side. 32 So too, a Levite, when he came to the place and saw him, passed by on the other side. 33 But a Samaritan, as he traveled, came where the man was; and when he saw him, he took pity on him. 34 He went to him and bandaged his wounds, pouring on oil and wine. Then he put the man on his own donkey, brought him to an inn and took care of him. 35 The next day he took out two denarii[c] and gave them to the innkeeper. ‘Look after him,’ he said, ‘and when I return, I will reimburse you for any extra expense you may have.’
36 “Which of these three do you think was a neighbor to the man who fell into the hands of robbers?”
37 The expert in the law replied, “The one who had mercy on him.”
Jesus told him, “Go and do likewise.”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:7e6gdj33irtt6i7vc6hozfah/bafkreighn5sh4h5qhpcb7pzh6icaxp4lybocxu5fduygkiyz4dl5cjd64i)
February 19, 2026 at 3:08 AM
this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me
it's a sin to walk past, never mind to exploit the victim further
it's a sin to walk past, never mind to exploit the victim further
Rather focus on expanding subcutaneous tissue as well.
Can and should one target visceral adipose tissue to improve cardiometabolic health? www.nature.com/articles/s43...
Visceral adiposity, metabolic health and aging - Nature Aging
Visceral adipose tissue (VAT), that is, white adipose tissue in the abdominal region, increases in midlife, and VAT expansion is associated with metabolic disorders. However, in this Review, the autho...
www.nature.com
February 19, 2026 at 4:42 PM
Rather focus on expanding subcutaneous tissue as well.
Reposted by Ranganath Muniyappa
Almost done with my next lecture, so going back now to work on some new memes
February 18, 2026 at 11:45 AM
Almost done with my next lecture, so going back now to work on some new memes
Reposted by Ranganath Muniyappa
❤️🩹 CHI Superhero Mohammedzayn on Hyperinsulinism:
“My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
“My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
February 6, 2026 at 10:00 AM
❤️🩹 CHI Superhero Mohammedzayn on Hyperinsulinism:
“My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
“My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
Reposted by Ranganath Muniyappa
My quote of the day
My dream is of a place and a time where America will once again be seen as the last best hope of earth.
Abraham Lincoln
My dream is of a place and a time where America will once again be seen as the last best hope of earth.
Abraham Lincoln
February 5, 2026 at 11:47 AM
My quote of the day
My dream is of a place and a time where America will once again be seen as the last best hope of earth.
Abraham Lincoln
My dream is of a place and a time where America will once again be seen as the last best hope of earth.
Abraham Lincoln
Reposted by Ranganath Muniyappa
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.
www.science.org
February 4, 2026 at 9:22 PM
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
Reposted by Ranganath Muniyappa
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro www.wsj.com/health/pharm...
Joel Habener, Whose Research Helped Develop Weight-Loss Drugs, Dies at 88
Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.
www.wsj.com
December 29, 2025 at 7:03 PM
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro www.wsj.com/health/pharm...
Reposted by Ranganath Muniyappa
My quote of the day
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
November 17, 2025 at 1:42 PM
My quote of the day
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
Reposted by Ranganath Muniyappa
One of my fav tik tok accounts was chandler and his grandma.
November 14, 2025 at 6:57 PM
One of my fav tik tok accounts was chandler and his grandma.
Reposted by Ranganath Muniyappa
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to:
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
October 19, 2025 at 8:00 AM
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to:
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
Reposted by Ranganath Muniyappa
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
🧵
🧵
October 12, 2025 at 2:10 PM
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
🧵
🧵