Nancy Santiappillai
@nancyts.bsky.social
Postdoc fellow in the Keshari lab @MSKCC interested in cancer metabolism, mass spec, imaging, and therapeutics. 🇳🇿 -> 🇦🇺-> 🇺🇸🗽
So happy to see our work @Kesharilab with @justinperryphd.bsky.social published, where we show a metabolic symbiosis between macrophages and TNBC cells!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Macrophage-supported metabolic adaptation drives tumor survival under nutrient stress
Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macrophage-...
www.science.org
October 3, 2026 at 9:49 PM
So happy to see our work @Kesharilab with @justinperryphd.bsky.social published, where we show a metabolic symbiosis between macrophages and TNBC cells!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Late to post, but so greatful to have presented my talk on prostate cancer metabolism at the @ismrm.bsky.social workshop on Metabolomics and Metabolomic Imaging in Medicine in Padua, Italy! And to be awarded Top Abstract!
February 20, 2026 at 11:57 PM
Late to post, but so greatful to have presented my talk on prostate cancer metabolism at the @ismrm.bsky.social workshop on Metabolomics and Metabolomic Imaging in Medicine in Padua, Italy! And to be awarded Top Abstract!
Reposted by Nancy Santiappillai
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 10:11 AM
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
Reposted by Nancy Santiappillai
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology
imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial
cell lines grown in their respective standard conditions reveals common and distinctive
metabolic signatur...
www.embopress.org
June 6, 2025 at 1:23 AM
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
Had a great time sharing our work on macrophage TNBC symbiosis at the NYAS Cancer and Metabolism symposium!
April 8, 2025 at 9:39 PM
Had a great time sharing our work on macrophage TNBC symbiosis at the NYAS Cancer and Metabolism symposium!
Reposted by Nancy Santiappillai
In @cp-cancercell.bsky.social, Schild et al. @mskcancercenter.bsky.social engineered T cells & CAR T cells to express the fructose-specific transporter GLUT5, improving T cell glycolytic flux & thus effector function in glucose-limited conditions.
📖 the #researchhighlight 👇
📖 the #researchhighlight 👇
Sweet success in CAR T cells - Nature Reviews Cancer
Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.
bit.ly
April 1, 2025 at 2:53 PM
In @cp-cancercell.bsky.social, Schild et al. @mskcancercenter.bsky.social engineered T cells & CAR T cells to express the fructose-specific transporter GLUT5, improving T cell glycolytic flux & thus effector function in glucose-limited conditions.
📖 the #researchhighlight 👇
📖 the #researchhighlight 👇