Niko Fleischer
@nikofleischer.bsky.social
Grad student with @ruth_stassart and @rfledrich @Paul-Flechsig-Institut Leipzig. Neuropathology, peripheral nerves, Schwann cells, Axon-Glia interactions from bed to bench to count matrix.
single-cell tx | spatial tx | image analysis | stats | data viz
single-cell tx | spatial tx | image analysis | stats | data viz
😱
Thoughts and prayers for research data managers everywhere. You are not alone. We will get through this together techcommunity.microsoft.com/blog/excelbl...
Excel now supports multiple values in a single cell | Microsoft Community Hub
Lists, arrays in cells, and nested arrays introduce new ways to store and organize related information, helping you keep data together without sacrificing...
techcommunity.microsoft.com
September 25, 2026 at 8:51 AM
😱
Reposted by Niko Fleischer
Straight talk time: Doomerism is BORING. It's the same fantasties rehashed over and over again, just louder each time.
And with each iteration it seems that new audiences are being reached, and a new group of people needs to be talked down
from unnecessary fear.
>>
And with each iteration it seems that new audiences are being reached, and a new group of people needs to be talked down
from unnecessary fear.
>>
September 13, 2026 at 1:06 AM
Straight talk time: Doomerism is BORING. It's the same fantasties rehashed over and over again, just louder each time.
And with each iteration it seems that new audiences are being reached, and a new group of people needs to be talked down
from unnecessary fear.
>>
And with each iteration it seems that new audiences are being reached, and a new group of people needs to be talked down
from unnecessary fear.
>>
Reposted by Niko Fleischer
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
September 5, 2026 at 2:48 PM
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
Reposted by Niko Fleischer
Part of the issue is the world doesn’t owe you an answer just because you have an interesting question, and I suspect many of our interesting social science questions will go unanswered for a very long time.
May 27, 2026 at 2:22 PM
Part of the issue is the world doesn’t owe you an answer just because you have an interesting question, and I suspect many of our interesting social science questions will go unanswered for a very long time.
Reposted by Niko Fleischer
Awesome idea, bridging Excel with ggplot2 ⬇️
Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
www.biorxiv.org
May 22, 2026 at 10:17 AM
Awesome idea, bridging Excel with ggplot2 ⬇️
Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
Reposted by Niko Fleischer
As a predominantly inattentive ADHDer, the only way that an LLM could 'help' me write is with cognitive offloading, which is actually a lie, and one that I do not trust.
For grammar checking, there is a great open source alternative to Grammarly which is entirely non-LLM called Harper.
For grammar checking, there is a great open source alternative to Grammarly which is entirely non-LLM called Harper.
Harper | Privacy-First Offline Grammar Checker
Harper checks your writing instantly—fast, lightweight and utterly private—so you can polish every clause without surrendering a single keystroke.
writewithharper.com
April 20, 2026 at 7:44 AM
As a predominantly inattentive ADHDer, the only way that an LLM could 'help' me write is with cognitive offloading, which is actually a lie, and one that I do not trust.
For grammar checking, there is a great open source alternative to Grammarly which is entirely non-LLM called Harper.
For grammar checking, there is a great open source alternative to Grammarly which is entirely non-LLM called Harper.
Reposted by Niko Fleischer
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs - Nature Neuroscience
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
www.nature.com
March 19, 2026 at 10:01 AM
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Niko Fleischer
Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
March 18, 2026 at 7:42 AM
Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Reposted by Niko Fleischer
kallisto sped up RNA-seq quantification by 50x. Now another 50x speedup... quantify hundreds of millions of reads in a few seconds.
This seems too good to be true. But it's true!
Incredible accomplishment by @pmelsted.bsky.social.
This seems too good to be true. But it's true!
Incredible accomplishment by @pmelsted.bsky.social.
Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data.
The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k...
Figure 1 shows they key result
The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k...
Figure 1 shows they key result
March 6, 2026 at 8:28 PM
kallisto sped up RNA-seq quantification by 50x. Now another 50x speedup... quantify hundreds of millions of reads in a few seconds.
This seems too good to be true. But it's true!
Incredible accomplishment by @pmelsted.bsky.social.
This seems too good to be true. But it's true!
Incredible accomplishment by @pmelsted.bsky.social.
Reposted by Niko Fleischer
Errors. Call them errors ffs. They're not hallucinations they're not lies. Call them errors. This dumbass personification of a fancy prediction tool is only reinforcing the idea that these things really are intelligent and not just a computer program.
"On one test, the hallucination rates of newer A.I. systems were as high as 79 percent."
www.nytimes.com/2025/05/05/t...
www.nytimes.com/2025/05/05/t...
A.I. Is Getting More Powerful, but Its Hallucinations Are Getting Worse
www.nytimes.com
May 6, 2025 at 6:06 PM
Errors. Call them errors ffs. They're not hallucinations they're not lies. Call them errors. This dumbass personification of a fancy prediction tool is only reinforcing the idea that these things really are intelligent and not just a computer program.
Reposted by Niko Fleischer
Congratulations to @jonathangoeke.bsky.social, and our @astar-gis.bsky.social team on your SG-NEx project, providing a comprehensive resource that enables the development and benchmarking of computational methods for profiling complex transcriptional events at isoform-level resolution.
An Analysis presents benchmarking results from the Singapore Nanopore Expression consortium project, plus a valuable resource of datasets generated from various long-read and short-read RNA sequencing technologies.
@jonathangoeke.bsky.social @astar-gis.bsky.social
www.nature.com/articles/s41...
@jonathangoeke.bsky.social @astar-gis.bsky.social
www.nature.com/articles/s41...
March 21, 2025 at 3:14 AM
Congratulations to @jonathangoeke.bsky.social, and our @astar-gis.bsky.social team on your SG-NEx project, providing a comprehensive resource that enables the development and benchmarking of computational methods for profiling complex transcriptional events at isoform-level resolution.