How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...

Congratulations 🎉 We thank all the coauthors including 4 co-first authors: @masaashimazoe.bsky.social @shiori-iida.bsky.social @katsuminami.bsky.social Higashi-san 🔬👏 Special thanks to @healthcare.nikon.com for 3D-SIM support. Modeling movie by Fujishiro-san. (2/2)

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗
www.nature.com/articles/s41... (1/2)