Redwan Farooq
@redwanfarooq.bsky.social
Neurology Resident | Postdoctoral Clinical Research Fellow | Multiple sclerosis | Neuroimmunology | Computational biology
Pinned
🧩 B cell depletion is highly effective in multiple sclerosis.
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/
Interesting study showing MS pre-relapse marked by shifts in peripheral innate immune cell states, linked to lytic EBV in ABCs. This contrasts with the pathology of smouldering CNS inflammation, highlighting a split pathogenic mechanism possibly unified by anti-EBV immunity? 🦠🧠
New article today: EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse Read more via link:
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse
Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.
dlvr.it
September 17, 2026 at 8:45 AM
Interesting study showing MS pre-relapse marked by shifts in peripheral innate immune cell states, linked to lytic EBV in ABCs. This contrasts with the pathology of smouldering CNS inflammation, highlighting a split pathogenic mechanism possibly unified by anti-EBV immunity? 🦠🧠
🧩 B cell depletion is highly effective in multiple sclerosis.
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/
September 11, 2026 at 3:26 PM
🧩 B cell depletion is highly effective in multiple sclerosis.
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/
But why?
In our new @brain1878.bsky.social paper, we used ocrelizumab as a perturbation, uncovering a B cell-dependent T cell state linking peripheral immune activation to chronic CNS inflammation.
doi.org/10.1093/brain/awag303
🧵👇
1/