We are hiring wet-lab postdocs to join our efforts to uncover RNA biology with interpretable ML and develop novel RNA therapeutic approaches using synthetic biology and high-throughput assays.
Reposts appreciated!
We are hiring wet-lab postdocs to join our efforts to uncover RNA biology with interpretable ML and develop novel RNA therapeutic approaches using synthetic biology and high-throughput assays.
Reposts appreciated!
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.