Josef M Klein
@resurgequality.bsky.social
Societies infrastructure to create knowledge is mainly built on the mud, that comes from the trust into organisations with inherent conflict of interests and the means to fabricate any type of raw data. I have ideas but not the funding nor time to get it.
Pinned
Josef M Klein
@resurgequality.bsky.social
· Apr 30
The Boston Globe agrees: Citizens United did not create SuperPACs, and it is time for the First Circuit to fix that absurd mistake.
www.bostonglobe.com/2026/04/26/o...
www.bostonglobe.com/2026/04/26/o...
A way out of super PAC madness? - The Boston Globe
If they act quickly on a Maine case, federal judges could tee up a Supreme Court decision next year that restores some sanity to campaign finance laws.
www.bostonglobe.com
People misunderstand how a small court ruling in the US can have GLOBAL consequences far bigger in reach than some wars.
Reposted by Josef M Klein
It’s not too late to stop this madness - the government has said the uk mega donors are a problem. The lords can bring in a cap on UK donors to stop any attempt to buy the next election. Share this and ask your MP to join us protecting British democracy.
September 11, 2026 at 9:23 PM
It’s not too late to stop this madness - the government has said the uk mega donors are a problem. The lords can bring in a cap on UK donors to stop any attempt to buy the next election. Share this and ask your MP to join us protecting British democracy.
Reposted by Josef M Klein
Who would like to guess why UK, US and European media outlets are not publishing 3,000 articles per minute about this
www.dukechronicle.com/article/duke...
www.dukechronicle.com/article/duke...
‘Insane data’: Duke professor Dan Ariely accused of additional research fraud
New evidence released Monday shows that Dan Ariely, professor of business administration in the Fuqua School of Business, likely tampered with or fabricated data in an influential research paper from ...
www.dukechronicle.com
September 2, 2026 at 5:56 PM
Who would like to guess why UK, US and European media outlets are not publishing 3,000 articles per minute about this
www.dukechronicle.com/article/duke...
www.dukechronicle.com/article/duke...
His is such an enormous clusterfudge I can't reach the end if the thought here.
-False claims act (sold to USGov)
-Class action lawsuit (customers)
-Papers that used these antibodies
-Papers that built on them
-All the failed experiments that need to be revisited
-all the money lost..what else?
-False claims act (sold to USGov)
-Class action lawsuit (customers)
-Papers that used these antibodies
-Papers that built on them
-All the failed experiments that need to be revisited
-all the money lost..what else?
First new entry to the wall of shame is Boster Biological Technology. In a statement to @huanjia.bsky.social for @genomeweb.bsky.social (link below), they state that some of the antibodies they sell are produced by third parties and that these "tend to be of lesser quality".
August 31, 2026 at 5:30 PM
His is such an enormous clusterfudge I can't reach the end if the thought here.
-False claims act (sold to USGov)
-Class action lawsuit (customers)
-Papers that used these antibodies
-Papers that built on them
-All the failed experiments that need to be revisited
-all the money lost..what else?
-False claims act (sold to USGov)
-Class action lawsuit (customers)
-Papers that used these antibodies
-Papers that built on them
-All the failed experiments that need to be revisited
-all the money lost..what else?
Reposted by Josef M Klein
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne.
1/🧵
1/🧵
August 25, 2026 at 1:06 PM
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne.
1/🧵
1/🧵
Reposted by Josef M Klein
Wiley's Research Integrity team tells me: "investigation has concluded that there are no serious concerns about the citation activity"
Guo has been fired/left his University after I reported his citation extortion practices, so something isn't adding up here...
pubpeer.com/publications...
Guo has been fired/left his University after I reported his citation extortion practices, so something isn't adding up here...
pubpeer.com/publications...
August 28, 2026 at 5:12 PM
Wiley's Research Integrity team tells me: "investigation has concluded that there are no serious concerns about the citation activity"
Guo has been fired/left his University after I reported his citation extortion practices, so something isn't adding up here...
pubpeer.com/publications...
Guo has been fired/left his University after I reported his citation extortion practices, so something isn't adding up here...
pubpeer.com/publications...
Reposted by Josef M Klein
Thoughts on the latest Alzheimer’s data scandal:
More Alzheimer's Research Trouble
www.science.org
August 18, 2026 at 7:48 PM
Thoughts on the latest Alzheimer’s data scandal:
Reposted by Josef M Klein
Weekend reads: Tragic news on former Cambridge prof; A ‘never AI’ research company was AI after all; OpenAI’s math breakthroughs don’t add up
Weekend reads: Tragic news on former Cambridge prof; A ‘never AI’ research company was AI after all; OpenAI’s math breakthroughs don’t add up
As we were assembling this week’s Weekend Reads, we learned the tragic news that former Cambridge professor Jason Arday had been found dead in his home. Arday has been the subject of several …
retractionwatch.com
August 15, 2026 at 12:29 PM
Weekend reads: Tragic news on former Cambridge prof; A ‘never AI’ research company was AI after all; OpenAI’s math breakthroughs don’t add up
Reposted by Josef M Klein
I’ve been told for years that it’s legally and ethically impossible to share medical RCT data.
In 2024, the BMJ made sharing anonymised data mandatory, and now lots* of folk do it.
Interesting how the barriers evaporated like that, isn’t it?
*not everyone, compliance problems exist.
In 2024, the BMJ made sharing anonymised data mandatory, and now lots* of folk do it.
Interesting how the barriers evaporated like that, isn’t it?
*not everyone, compliance problems exist.
Availability of clinical trial individual patient data in the BMJ before and after adoption of a stringent data-sharing policy, compared with recent rates at other major medical journals
Background In 2024, the BMJ updated its data-sharing policy for clinical trials, requiring open deposit of deidentified individual participant data (IPD) before publication. We considered whether data...
www.medrxiv.org
August 14, 2026 at 7:33 AM
I’ve been told for years that it’s legally and ethically impossible to share medical RCT data.
In 2024, the BMJ made sharing anonymised data mandatory, and now lots* of folk do it.
Interesting how the barriers evaporated like that, isn’t it?
*not everyone, compliance problems exist.
In 2024, the BMJ made sharing anonymised data mandatory, and now lots* of folk do it.
Interesting how the barriers evaporated like that, isn’t it?
*not everyone, compliance problems exist.
If there is a profitable demand and a service one can privide that is not illegal, then nature has to provide the service, I mean everything else is gross negligence towards stockholders.
August 14, 2026 at 6:43 AM
If there is a profitable demand and a service one can privide that is not illegal, then nature has to provide the service, I mean everything else is gross negligence towards stockholders.
Reposted by Josef M Klein
This company pitched us a guest post on "retracted trials that live on inside meta-analyses." Perfectly reasonable subject, but the text seemed fishy.
Turns out it was *very* fishy, we now learn thanks to @emanuelmaiberg.bsky.social of @404media.co.
Turns out it was *very* fishy, we now learn thanks to @emanuelmaiberg.bsky.social of @404media.co.
Company Offering ‘100% Human-Written, Never AI’ Medical Research Is Entirely AI
Research Gold's team of human methodologists are either AI generated or using the identity of real people without their permission
www.404media.co
August 11, 2026 at 8:13 PM
This company pitched us a guest post on "retracted trials that live on inside meta-analyses." Perfectly reasonable subject, but the text seemed fishy.
Turns out it was *very* fishy, we now learn thanks to @emanuelmaiberg.bsky.social of @404media.co.
Turns out it was *very* fishy, we now learn thanks to @emanuelmaiberg.bsky.social of @404media.co.
Reposted by Josef M Klein
I spoke to Weekend Edition's Scott Simon about the Maine initiative to end Super PACs (now being considered by the First Circuit): https://www.npr.org/2026/08/08/nx-s1-5922464/legal-scholar-lawrence-lessig-on-how-a-maine-law-could-topple-super-pacs
August 8, 2026 at 2:47 PM
I spoke to Weekend Edition's Scott Simon about the Maine initiative to end Super PACs (now being considered by the First Circuit): https://www.npr.org/2026/08/08/nx-s1-5922464/legal-scholar-lawrence-lessig-on-how-a-maine-law-could-topple-super-pacs
Reposted by Josef M Klein
How to waste 800,000 💶,
Bavarian style..🙄
Bavarian style..🙄
The Bavarian homeopathy trial: no evidence that homeopathy is superior to placebo edzardernst.com/2026/08/the-...
The Bavarian homeopathy trial: no evidence that homeopathy is superior to placebo
Remember the Bavarian homeopathy trial, sponsored by the Bavarian government? I reported about it several times: The ‘Bavarian Homeopathy Study’ has been aborted More information about the Bavarian Ho...
edzardernst.com
August 7, 2026 at 4:44 PM
How to waste 800,000 💶,
Bavarian style..🙄
Bavarian style..🙄
And does it shift the Systematic reviews outcomes? This is exactly the kind of stuff expected to occur to either unintentionally shift results (studies hiding behind assumed truths) or sway them on purpose (conflict of interests). Its even in cardio. That's the stuff James Heathers should work at.
We published a new paper in the #CanadianJournalOfCardiology
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
August 6, 2026 at 11:07 PM
And does it shift the Systematic reviews outcomes? This is exactly the kind of stuff expected to occur to either unintentionally shift results (studies hiding behind assumed truths) or sway them on purpose (conflict of interests). Its even in cardio. That's the stuff James Heathers should work at.
Reposted by Josef M Klein
We published a new paper in the #CanadianJournalOfCardiology
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
August 6, 2026 at 5:52 PM
We published a new paper in the #CanadianJournalOfCardiology
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
doi.org/10.1016/j.cj...
We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.
Reposted by Josef M Klein
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials
The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....
www.medrxiv.org
September 5, 2025 at 6:11 PM
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
1) Na toll, jetzt gibts nur noch Wildoktopus und die population schwindet. Kein Zucht-Bio Oktopus.
Geschafft!
"Die geplante tierquälerische Oktopus-Fabrik auf Gran Canaria wird nicht gebaut: Der Konzern Nueva Pescanova hat sein Oktopuszucht-Projekt endgültig abgesagt. Dank uns."
www.worldanimalprotection.org/latest/news/...
"Die geplante tierquälerische Oktopus-Fabrik auf Gran Canaria wird nicht gebaut: Der Konzern Nueva Pescanova hat sein Oktopuszucht-Projekt endgültig abgesagt. Dank uns."
www.worldanimalprotection.org/latest/news/...
Victory! World's First Octopus Farm Plans Scrapped
Plans for the world's first commercial octopus farm have been abandoned after years of sustained pressure from NGOs, scientists and the public.
www.worldanimalprotection.org
July 31, 2026 at 9:22 PM
1) Na toll, jetzt gibts nur noch Wildoktopus und die population schwindet. Kein Zucht-Bio Oktopus.
People should really be careful with those kind or jokes. They basically deny that any safety testing is needed before any harm is known. Rather point to data that shows safety than to deny the need for safety. Or go buy your muuuch cheaper Chinese car that had 0 safety testing.
The claim “RFK Jr. does not fuck chickens” is not an evidence-based claim because studies have not ruled out the possibility that RFK Jr. fucks chickens.
July 24, 2026 at 9:32 PM
People should really be careful with those kind or jokes. They basically deny that any safety testing is needed before any harm is known. Rather point to data that shows safety than to deny the need for safety. Or go buy your muuuch cheaper Chinese car that had 0 safety testing.
Reposted by Josef M Klein
Astonishing.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
FDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)
In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
www.nytimes.com
July 24, 2026 at 10:39 AM
Astonishing.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
Reposted by Josef M Klein
Yea but it’s just the Pharma industry that’s corrupt.
Astonishing.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist.
In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
FDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)
In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
www.nytimes.com
July 24, 2026 at 6:38 PM
Yea but it’s just the Pharma industry that’s corrupt.
Reposted by Josef M Klein
For years now, whenever someone has asked me about people who want to “hack their own genomes”, I have asked them if they recognize the name “Jesse Gelsinger”.
Now I’ll also ask if they’ve ever heard of a six-year-old Chinese girl known to us only as Mei.
Now I’ll also ask if they’ve ever heard of a six-year-old Chinese girl known to us only as Mei.
July 23, 2026 at 8:42 PM
For years now, whenever someone has asked me about people who want to “hack their own genomes”, I have asked them if they recognize the name “Jesse Gelsinger”.
Now I’ll also ask if they’ve ever heard of a six-year-old Chinese girl known to us only as Mei.
Now I’ll also ask if they’ve ever heard of a six-year-old Chinese girl known to us only as Mei.
Reposted by Josef M Klein
A major story broken by Science and Retraction Watch: an unreported death in a human gene therapy attempt in China:
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
www.science.org
July 23, 2026 at 8:32 PM
A major story broken by Science and Retraction Watch: an unreported death in a human gene therapy attempt in China:
Soon it will be JAImes Heathers Agentic Sleuthing.
Next: Colby Vorland with "AI-Assisted Integrity Checks: Initial Validation Results From the INSPECT-AI Tool for Retraction and Trial Registration in Randomized Controlled Trials"
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
July 22, 2026 at 6:10 PM
Soon it will be JAImes Heathers Agentic Sleuthing.
Reposted by Josef M Klein
Next: Colby Vorland with "AI-Assisted Integrity Checks: Initial Validation Results From the INSPECT-AI Tool for Retraction and Trial Registration in Randomized Controlled Trials"
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
May 6, 2026 at 5:49 PM
Next: Colby Vorland with "AI-Assisted Integrity Checks: Initial Validation Results From the INSPECT-AI Tool for Retraction and Trial Registration in Randomized Controlled Trials"
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
Checking trials for integrity issues to find concerns, because retracted trials can be influential.
#WCRI2026
Isn't there tens of billions lost by healthcare fraud, defrauding the government directly by middlemen? Not even individual tax payers?
It would be nice if, at the very least, the people reporting on this stuff properly contextualized it by explicitly stating that if the president can do this the union has ceased to exist. It's not hyperbole or figurative language. There is no union. "Unconstitutional" doesn't cover it.
Trump administration pauses $1 bln in Medicaid payments to California, Minnesota www.reuters.com/world/us-hea...
July 22, 2026 at 10:52 AM
Isn't there tens of billions lost by healthcare fraud, defrauding the government directly by middlemen? Not even individual tax payers?
Reposted by Josef M Klein
Today we launch the first stable release of RegCheck: v1.0.0.
RegCheck makes it easier and quicker to compare study registrations to published papers for consistency - something we know is important in principle, but rarely done in practice.
A 🧵 on what's new:
regcheck.app
RegCheck makes it easier and quicker to compare study registrations to published papers for consistency - something we know is important in principle, but rarely done in practice.
A 🧵 on what's new:
regcheck.app
RegCheck
RegCheck is an AI tool to compare preregistrations with papers instantly.
regcheck.app
July 14, 2026 at 3:12 PM
Today we launch the first stable release of RegCheck: v1.0.0.
RegCheck makes it easier and quicker to compare study registrations to published papers for consistency - something we know is important in principle, but rarely done in practice.
A 🧵 on what's new:
regcheck.app
RegCheck makes it easier and quicker to compare study registrations to published papers for consistency - something we know is important in principle, but rarely done in practice.
A 🧵 on what's new:
regcheck.app