robbieclark.bsky.social
@robbieclark.bsky.social
Reposted by robbieclark.bsky.social
Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes #chemsky
Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes
Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02155-0The extent to which crystal packing constrains protein dynamics is hard to decipher. Now a combination of NMR, crystallography and molecular dynamics simulations show that intermolecular contacts can slow ring flips down in crystals or accelerated them in complexes. A thermodynamic and structural analysis provides insights into the origins of the elevated free-energy barrier in crystals.
dlvr.it
June 10, 2026 at 3:04 PM
Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes #chemsky
Had so much fun with this work! Check it out!
We just preprinted one of my favorite studies @FlatironInst
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
April 27, 2026 at 2:07 PM
Had so much fun with this work! Check it out!
Reposted by robbieclark.bsky.social
Having heard updates on this project at many stages from @robbieclark.bsky.social I can say that this is an amazing work.
Congratulations to everyone on the team and to Robbie 🎉
Congratulations to everyone on the team and to Robbie 🎉
We just preprinted one of my favorite studies @FlatironInst
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
April 26, 2026 at 10:53 AM
Having heard updates on this project at many stages from @robbieclark.bsky.social I can say that this is an amazing work.
Congratulations to everyone on the team and to Robbie 🎉
Congratulations to everyone on the team and to Robbie 🎉
Reposted by robbieclark.bsky.social
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology
Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...
www.nature.com
April 25, 2025 at 3:35 PM
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by robbieclark.bsky.social
New study led by @georgiaisom.bsky.social and Ben Cooper. Sims by Robbie Clark. Exps & sims reveal phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP www.sciencedirect.com/science/arti... @dunnschool.bsky.social @oxfordbiochemistry.bsky.social
Phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP
The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis o…
www.sciencedirect.com
December 7, 2024 at 6:30 PM
New study led by @georgiaisom.bsky.social and Ben Cooper. Sims by Robbie Clark. Exps & sims reveal phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP www.sciencedirect.com/science/arti... @dunnschool.bsky.social @oxfordbiochemistry.bsky.social
Reposted by robbieclark.bsky.social
In a multidisciplinary study led by Georgina Benn and Tom Silhavy we show the role of OmpA in controlling the organisation of the outer membrane and in sharing the mechanical load. www.pnas.org/doi/10.1073/....
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 4, 2024 at 10:07 PM
In a multidisciplinary study led by Georgina Benn and Tom Silhavy we show the role of OmpA in controlling the organisation of the outer membrane and in sharing the mechanical load. www.pnas.org/doi/10.1073/....