- Elanga (NEW), Unspecified injury - Unknown return date
- Tonali (TOT), Knock - 75% chance of playing

- Mendy (HUL), Concussion - 50% chance of playing
- Milenković (NFO), Hamstring injury - 75% chance of playing
- Jair Cunha (NFO), Hamstring injury - 75% chance of playing
- Reinildo (SUN), Suspended until 10 Oct

- Pedro Porro (TOT), Unspecified injury - 75% chance of playing
- Udogie (TOT), Unspecified injury - 75% chance of playing
- Mudryk (TOT), Ankle injury - Unknown return date

- Morita (HUL), Calf injury - Expected back 11 Oct
- Ansah (HUL), Back injury - Unknown return date
- Gakpo (LIV), Thigh injury - 75% chance of playing
- Dedić (NEW), Hamstring injury - 75% chance of playing
- Mundle (SUN), Knee injury - Unknown return date

- Johnson (IPS), Has joined Stoke City on loan for the rest of the season
- Neave (NEW), Has joined Wolves on loan for the rest of the season
- Moore (TOT), Has joined FC Köln on loan for the rest of the season
- Richarlison (TOT), not included in squad.

- Lynch (AVL), Has joined Oxford United on loan until January
- Dasilva (BRE), Hamstring injury - Expected back 10 Oct
- Wieffer (BHA), Knee injury - Unknown return date
- Azeez (BHA), Unspecified injury - Expected back 13 Sep

- Abbott (NFO), Has joined Southampton on loan for the rest of the season
- P.M.Sarr (TOT), Has joined Juventus on loan for the rest of the season
- Scarlett (TOT), Has joined Leyton Orient permanently

- Monga (MCI), Has joined Swansea City on loan for the rest of the season
- Woltemade (NEW), Has joined Juventus on loan for the rest of the season
- Morato (NFO), Has joined West Ham on loan for the rest of the season

- Humphreys (IPS), Has joined Huddersfield Town on loan for the rest of the season
- Gnonto (LEE), Has joined ACF Fiorentina on loan for the rest of the season
- Elliott (LIV), Has joined Valencia on loan for the rest of the season

- Beto (EVE), Has joined Fiorentina permanently
- Drameh (HUL), Has joined Genoa permanently
- Millar (HUL), Has joined Birmingham on loan for the rest of the season
- Ogbene (IPS), Has joined Lincoln City on loan until January

- Sosa (CRY), Has joined FC Cologne on loan for the rest of the season
- Devenny (CRY), Has joined Stoke City permanently
- Esse (CRY), Has joined Millwall on loan for the rest of the season
- Patterson (EVE), Has joined Torino permanently

- Dovin (COV), Has joined Leyton Orient on loan for the rest of the season
- Kitching (COV), Has joined Sheffield United on loan for the rest of the season
- Borges Rodrigues (COV), Has joined Burton Albion on loan for the rest of the season

- Cozier-Duberry (BHA), Has joined Middlesbrough on loan for the rest of the season
- Sánchez (CHE), Has joined Como on loan for the rest of the season
- D.Essugo (CHE), Has joined RC Strasbourg on loan for the rest of the season

- Hutchinson (NFO), Has joined AC Milan on loan for the rest of the season
- Souza (TOT), Has joined FC Porto on loan for the rest of the season