Snedeker Lab at University and ETH Zurich
@snedeker-lab.bsky.social
Jointly affiliated with the University Hospital Balgrist and the ETH Zurich.
We are a multidisciplinary research unit dedicated to scientific discovery and medical innovation.
We are a multidisciplinary research unit dedicated to scientific discovery and medical innovation.
Out today in Nature Communications: @Amro_Hussien shows that tendon fibrosis in systemic sclerosis is mechanically gated.
We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
www.nature.com/articles/s41...
We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
www.nature.com/articles/s41...
Mechanical gating of tendon fibrogenic transcription in systemic sclerosis - Nature Communications
A tunable tendon-like mechano-culture system shows that matrix tension drives myofibroblast activation in systemic sclerosis, while immune cells override tension-mediated control of fibrotic gene expr...
www.nature.com
April 29, 2026 at 7:54 AM
Out today in Nature Communications: @Amro_Hussien shows that tendon fibrosis in systemic sclerosis is mechanically gated.
We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
www.nature.com/articles/s41...
We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
www.nature.com/articles/s41...
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine www.science.org/doi/10.1126/...
Great collaboration with the de Bock Lab @ethz.ch
#tendon #tendinopathy #mechanobiology #HIF1a #ECM
@snsf.ch @ethz.ch @med.uzh.ch
Great collaboration with the de Bock Lab @ethz.ch
#tendon #tendinopathy #mechanobiology #HIF1a #ECM
@snsf.ch @ethz.ch @med.uzh.ch
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment
HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.
www.science.org
January 11, 2026 at 3:05 PM
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine www.science.org/doi/10.1126/...
Great collaboration with the de Bock Lab @ethz.ch
#tendon #tendinopathy #mechanobiology #HIF1a #ECM
@snsf.ch @ethz.ch @med.uzh.ch
Great collaboration with the de Bock Lab @ethz.ch
#tendon #tendinopathy #mechanobiology #HIF1a #ECM
@snsf.ch @ethz.ch @med.uzh.ch