Sourav Agrawal | ସୌରଭ
@souravagrawal.bsky.social
Currently on a PhD. journey! UW Madison Biophysics Major! NISERite B16!
Reposted by Sourav Agrawal | ସୌରଭ
Congratulations to Toru and the rest of the authors! 🎉 Happy that @souravagrawal.bsky.social and I can be part of this work! Insights into telomerase-RPA interaction using fission yeast as a model system
I am pleased to share that our story on RPA (Replication Protein A) and telomerase is now out online at PLoS Genetics.
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Fission yeast RPA–TERT–Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination
Author summary Telomeres are specialized dynamic protective structures at the ends of eukaryotic chromosomes that must be properly maintained to preserve genome stability. Telomerase extends telomeric...
journals.plos.org
September 8, 2026 at 10:52 PM
Congratulations to Toru and the rest of the authors! 🎉 Happy that @souravagrawal.bsky.social and I can be part of this work! Insights into telomerase-RPA interaction using fission yeast as a model system
Reposted by Sourav Agrawal | ସୌରଭ
I am pleased to share that our story on RPA (Replication Protein A) and telomerase is now out online at PLoS Genetics.
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Fission yeast RPA–TERT–Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination
Author summary Telomeres are specialized dynamic protective structures at the ends of eukaryotic chromosomes that must be properly maintained to preserve genome stability. Telomerase extends telomeric...
journals.plos.org
September 8, 2026 at 9:18 PM
I am pleased to share that our story on RPA (Replication Protein A) and telomerase is now out online at PLoS Genetics.
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Reposted by Sourav Agrawal | ସୌରଭ
First-ever preprint from our lab, describing evidence that the RPA-Trt1-Tpz1 complex contributes to telomerase activation in fission yeast.
This story began when Yong-jie Xu from Wright State University sent us a collection of 25 Replication Protein A subunit Ssb1 (RPA1) mutants in 2021.
This story began when Yong-jie Xu from Wright State University sent us a collection of 25 Replication Protein A subunit Ssb1 (RPA1) mutants in 2021.
Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination https://www.biorxiv.org/content/10.64898/2026.04.26.720725v1
April 29, 2026 at 8:14 PM
First-ever preprint from our lab, describing evidence that the RPA-Trt1-Tpz1 complex contributes to telomerase activation in fission yeast.
This story began when Yong-jie Xu from Wright State University sent us a collection of 25 Replication Protein A subunit Ssb1 (RPA1) mutants in 2021.
This story began when Yong-jie Xu from Wright State University sent us a collection of 25 Replication Protein A subunit Ssb1 (RPA1) mutants in 2021.
Reposted by Sourav Agrawal | ସୌରଭ
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Reposted by Sourav Agrawal | ସୌରଭ
It's nice to have this back here !
Bluesky bot that surveys your literature research subfield 👍 #CryoEM
@cryoempapers.bsky.social
Bluesky bot that surveys your literature research subfield 👍 #CryoEM
@cryoempapers.bsky.social
November 19, 2024 at 7:15 AM
It's nice to have this back here !
Bluesky bot that surveys your literature research subfield 👍 #CryoEM
@cryoempapers.bsky.social
Bluesky bot that surveys your literature research subfield 👍 #CryoEM
@cryoempapers.bsky.social
Reposted by Sourav Agrawal | ସୌରଭ
Exhausted with trying multiple ways to combat the air-water interface (AWI) problem during sample grid plunge freezing? We may have an easy solution for you!
Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: www.biorxiv.org/content/10.1...
Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: www.biorxiv.org/content/10.1...
Small LEA proteins as an effective air-water interface protectant for fragile samples during cryo-EM grid plunge freezing
Sample loss due to air-water interface (AWI) interactions is a significant challenge during cryo-electron microscopy (cryo-EM) sample grid plunge freezing. We report that small Late Embryogenesis Abundant (LEA) proteins, which naturally bind to AWI, can protect samples from AWI damage during plunge freezing. This protection is demonstrated with two LEA proteins from nematodes and tardigrades, which rescued the cryo-EM structural determination outcome of two fragile multisubunit protein complexes. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
February 9, 2024 at 2:35 AM
Exhausted with trying multiple ways to combat the air-water interface (AWI) problem during sample grid plunge freezing? We may have an easy solution for you!
Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: www.biorxiv.org/content/10.1...
Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: www.biorxiv.org/content/10.1...