Upregulation of the Unfolded and Mitochondrial Unfolded Protein Responses in Oxidative Stress-Induced Cataract https://www.biorxiv.org/content/10.64898/2026.08.19.745850v1

Join us TOMORROW for Sarah Zelle’s Chemical and Physical Biology dissertation defense: “Proteomic dissection of Nrf2 and αB-crystallin–mediated oxidative stress responses in the zebrafish lens.”

📅 Mar 6 | 9 AM
📍 Preston Research Building 206

My first first‑author paper is out in JASMS! We used diaPASEF proteomics on separated zebrafish lens regions and saw a 200%+ increase in protein group IDs compared to an Orbitrap DIA method, achieving new levels of proteomic coverage in the zebrafish lens. pubs.acs.org/doi/10.1021/...

Excited to present my poster “diaPASEF analysis of mutant zebrafish lenses under oxidative stress” (TP 201) at #ASMS2025 in Baltimore next Tuesday!

If you’re interested in proteomics, aging biology, or oxidative stress, I’d love to connect.

Data-independent acquisition parallel accumulation-serial fragmentation (diaPASEF) analysis of the separated zebrafish lens improves identifications https://www.biorxiv.org/content/10.1101/2025.03.13.642445v1