TBE · antimicrobial resistance · rare infections
📜 How infections shaped history, art & fashion
Papers, clinical cases & curiosities #IDSky
Choice and duration both matter: late-gen cephalosporins, some quinolones and carbapenems top the risk scale.
Stewardship = limiting collateral damage. 🌿
📖 doi.org/10.1128/cmr.00135-23
#CDiff #AMS #IDSky #Microbiome #Antibiotics
Choice and duration both matter: late-gen cephalosporins, some quinolones and carbapenems top the risk scale.
Stewardship = limiting collateral damage. 🌿
📖 doi.org/10.1128/cmr.00135-23
#CDiff #AMS #IDSky #Microbiome #Antibiotics
6 g/24h continuous infusion by elastomeric pump, 62 days, NDM-producing K. pneumoniae otomastoiditis.
TDM: 100% fT>4–6×MIC. No adverse events.
📄 doi.org/10.1093/jacamr/dlaf066
#IDSky #AMR #OPAT #Cefiderocol #Klebsiella #PKPD #MedSky
6 g/24h continuous infusion by elastomeric pump, 62 days, NDM-producing K. pneumoniae otomastoiditis.
TDM: 100% fT>4–6×MIC. No adverse events.
📄 doi.org/10.1093/jacamr/dlaf066
#IDSky #AMR #OPAT #Cefiderocol #Klebsiella #PKPD #MedSky
Human serum albumin binds SLO, the pore-forming toxin of S. pyogenes, via domain II: membranes stay intact, haemolysis drops.
A natural buffer against bacterial toxins? 🤔
#IDSky #MicroSky #MedSky #ImmunoSky #StrepA #iGAS #BacterialToxins #InnateImmunity #Streptococcus
Human serum albumin binds SLO, the pore-forming toxin of S. pyogenes, via domain II: membranes stay intact, haemolysis drops.
A natural buffer against bacterial toxins? 🤔
#IDSky #MicroSky #MedSky #ImmunoSky #StrepA #iGAS #BacterialToxins #InnateImmunity #Streptococcus
Our CID letter with Filippo Mearelli & Milo Gatti: retained hardware → think antibiofilm, not just MIC.
Rifampin, fosfomycin, ceftobiprole, daptomycin, delafloxacin.
📄 doi.org/10.1093/cid/ciaf064
#IDSky #MedSky #AMR #Biofilm #OrthoSky
Sterile larvae debride necrotic tissue, and their secretions are antibacterial, anti-biofilm and synergistic with antibiotics.
From battlefield medicine to the AMR era.
📄 doi.org/10.53854/liim-3302-11
#IDSky #AMR #WoundCare #histmed
Sterile larvae debride necrotic tissue, and their secretions are antibacterial, anti-biofilm and synergistic with antibiotics.
From battlefield medicine to the AMR era.
📄 doi.org/10.53854/liim-3302-11
#IDSky #AMR #WoundCare #histmed
Look carefully at the skin. And then at the eyebrows.
56-year-old man: diffuse erythematous lesions and sensory abnormalities.
What is your diagnosis?
👉 stefanodibella.it/clinical-challenge-9/
#ClinicalChallenge #IDsky #MedSky #DermSky #MedEd
Look carefully at the skin. And then at the eyebrows.
56-year-old man: diffuse erythematous lesions and sensory abnormalities.
What is your diagnosis?
👉 stefanodibella.it/clinical-challenge-9/
#ClinicalChallenge #IDsky #MedSky #DermSky #MedEd
In 397 hospitalized #COVID19 patients, a larger neck was associated with 2.5× higher adjusted 30-day mortality hazard, independent of BMI.
doi.org/10.3390/idr1...
#IDSky #InfectiousDisease #MedSky #EpiSky #CriticalCare #Obesity #PublicHealth
In 397 hospitalized #COVID19 patients, a larger neck was associated with 2.5× higher adjusted 30-day mortality hazard, independent of BMI.
doi.org/10.3390/idr1...
#IDSky #InfectiousDisease #MedSky #EpiSky #CriticalCare #Obesity #PublicHealth
In lab studies, salicylate reduced capsular polysaccharide production by up to 70%, increasing susceptibility to phagocytosis.
Intriguing mechanism, not clinical proof.
Our review: doi.org/10.3390/biom...
In lab studies, salicylate reduced capsular polysaccharide production by up to 70%, increasing susceptibility to phagocytosis.
Intriguing mechanism, not clinical proof.
Our review: doi.org/10.3390/biom...
30 patients, a high-risk mix:
🔹 ESBL 56.7%
🔹 Bacteraemia 40%
🔹 Sepsis 50%
✅ Clinical success: 93.3%
A carbapenem-sparing option worth more attention.
📄 www.mdpi.com/2079-6382/15/10/1034
#IDSky #AMR #AntimicrobialStewardship
30 patients, a high-risk mix:
🔹 ESBL 56.7%
🔹 Bacteraemia 40%
🔹 Sepsis 50%
✅ Clinical success: 93.3%
A carbapenem-sparing option worth more attention.
📄 www.mdpi.com/2079-6382/15/10/1034
#IDSky #AMR #AntimicrobialStewardship
🏰 E. faecium: expect a fortress.
11 Italian hospitals - 4,858 enterococcal blood isolates.
Ampicillin resistance:
🔹 E. faecalis: 6.8%
🔸 E. faecium: 89.1%
doi.org/10.1089/mdr....
#Enterococcus #AntimicrobialResistance #Microbiology #AntimicrobialStewardship
🏰 E. faecium: expect a fortress.
11 Italian hospitals - 4,858 enterococcal blood isolates.
Ampicillin resistance:
🔹 E. faecalis: 6.8%
🔸 E. faecium: 89.1%
doi.org/10.1089/mdr....
#Enterococcus #AntimicrobialResistance #Microbiology #AntimicrobialStewardship
🇮🇹 5-year data:
Ureaplasma spp. → ciprofloxacin R 39.5%
M. hominis → azithromycin R 60.5%
Species identification matters.
📄 doi.org/10.1089/mdr....
#IDSky #AMR #ClinMicro #MedSky
🇮🇹 5-year data:
Ureaplasma spp. → ciprofloxacin R 39.5%
M. hominis → azithromycin R 60.5%
Species identification matters.
📄 doi.org/10.1089/mdr....
#IDSky #AMR #ClinMicro #MedSky
The “Blue Henry” (Blauer Heinrich) was a portable sputum flask used by tuberculosis patients.
It even appears in Thomas Mann’s The Magic Mountain, set in a tuberculosis sanatorium.
🎨 Artwork by Anna Dumitriu.
#IDSky #Tuberculosis
The “Blue Henry” (Blauer Heinrich) was a portable sputum flask used by tuberculosis patients.
It even appears in Thomas Mann’s The Magic Mountain, set in a tuberculosis sanatorium.
🎨 Artwork by Anna Dumitriu.
#IDSky #Tuberculosis
In selected patients, decompressive laminectomy was associated with neurological recovery, pain relief, and no delayed arthrodesis.
📄 doi.org/10.3390/jpm1...
In selected patients, decompressive laminectomy was associated with neurological recovery, pain relief, and no delayed arthrodesis.
📄 doi.org/10.3390/jpm1...
Ulcerated cutaneous lesions with extensive oral involvement in classical Sweet syndrome—an uncommon presentation with a broad differential diagnosis.
Ragonesi S et al., Dermatology Reports, 2026
doi.org/10.4081/dr.2...
Ulcerated cutaneous lesions with extensive oral involvement in classical Sweet syndrome—an uncommon presentation with a broad differential diagnosis.
Ragonesi S et al., Dermatology Reports, 2026
doi.org/10.4081/dr.2...
In TBE, tongue tremor has been reported in ~30% of patients during the neurological phase. This short video shows the finding in a woman with TBE from northeastern Italy.
Paper: doi.org/10.1136/pn-2...
#IDSky #TBE
In TBE, tongue tremor has been reported in ~30% of patients during the neurological phase. This short video shows the finding in a woman with TBE from northeastern Italy.
Paper: doi.org/10.1136/pn-2...
#IDSky #TBE
In KPC-Kp isolates, temocillin + fosfomycin showed 91% synergy.
In 97% of temocillin-resistant isolates, fosfomycin restored temocillin susceptibility
The combination also improved survival in animal model.
👉 lnkd.in/d8fZQ3Y9
In KPC-Kp isolates, temocillin + fosfomycin showed 91% synergy.
In 97% of temocillin-resistant isolates, fosfomycin restored temocillin susceptibility
The combination also improved survival in animal model.
👉 lnkd.in/d8fZQ3Y9
Clinical manifestations, diagnosis, epidemiology, treatment and prevention — with a focus on emerging neurological features.
📄 Read our review:
www.infezmed.it/media/journa...
#TBE #TickBorneEncephalitis #InfectiousDiseases
Clinical manifestations, diagnosis, epidemiology, treatment and prevention — with a focus on emerging neurological features.
📄 Read our review:
www.infezmed.it/media/journa...
#TBE #TickBorneEncephalitis #InfectiousDiseases
Wigs could hide hair loss, while facial patches may have concealed scars or skin lesions.
From syphilis to plague, TB, HIV/AIDS and COVID-19, infections have shaped fashion through history.
📖 rosa.uniroma1.it/rosa01/medic...
Wigs could hide hair loss, while facial patches may have concealed scars or skin lesions.
From syphilis to plague, TB, HIV/AIDS and COVID-19, infections have shaped fashion through history.
📖 rosa.uniroma1.it/rosa01/medic...
Happy to share our new systematic review & meta-analysis 📊✨
✅ 25 studies
✅ 2,480 patients
✅ case-fatality risk: 5%
Higher mortality was associated with:
🧫 C. fetus
🛡️ immunocompromised status
🟤 chronic liver disease
📖 lnkd.in/duJQgHR4
Happy to share our new systematic review & meta-analysis 📊✨
✅ 25 studies
✅ 2,480 patients
✅ case-fatality risk: 5%
Higher mortality was associated with:
🧫 C. fetus
🛡️ immunocompromised status
🟤 chronic liver disease
📖 lnkd.in/duJQgHR4
A small necrotic skin lesion in a neutropenic patient can be the only sign of a life-threatening infection.
Think Pseudomonas aeruginosa → act fast with empirical therapy.
🚀 Early recognition saves lives.
📄 Read more: rdcu.be/fbuu1
A small necrotic skin lesion in a neutropenic patient can be the only sign of a life-threatening infection.
Think Pseudomonas aeruginosa → act fast with empirical therapy.
🚀 Early recognition saves lives.
📄 Read more: rdcu.be/fbuu1
We report a rare cutaneous Scedosporium infection that clinically mimicked post-transplant malignancy — a potentially dangerous diagnostic pitfall.
doi.org/10.1016/j.di...
We report a rare cutaneous Scedosporium infection that clinically mimicked post-transplant malignancy — a potentially dangerous diagnostic pitfall.
doi.org/10.1016/j.di...
We explore the therapeutic potential of butyrate supplementation in sepsis: gut barrier protection, immune modulation, metabolic reprogramming.
Nice preclinical evidence; clinical translation remains an open challenge.
DOI: 10.1016/j.ejphar.2026.178594
We explore the therapeutic potential of butyrate supplementation in sepsis: gut barrier protection, immune modulation, metabolic reprogramming.
Nice preclinical evidence; clinical translation remains an open challenge.
DOI: 10.1016/j.ejphar.2026.178594