Structural Phylogenetics (StrPhy)
@strphy.bsky.social
Structural Phylogenetics • methods, datasets, tools, events • concise updates for researchers and practitioners. Managed by @proteinmechanic.bsky.social and @cpuentelelievre.bsky.social
Reposted by Structural Phylogenetics (StrPhy)
The 2026 SMBE Australasian Protein Structural Phylogenetics Meeting took place last week in Brisbane (Australia) to discuss this rapidly growing field.
Thank you to all participants and congratulations to the organizing team, who brought to life a fantastic event!👏
@strphy.bsky.social
#StrPhy26
Thank you to all participants and congratulations to the organizing team, who brought to life a fantastic event!👏
@strphy.bsky.social
#StrPhy26
February 26, 2026 at 11:21 PM
The 2026 SMBE Australasian Protein Structural Phylogenetics Meeting took place last week in Brisbane (Australia) to discuss this rapidly growing field.
Thank you to all participants and congratulations to the organizing team, who brought to life a fantastic event!👏
@strphy.bsky.social
#StrPhy26
Thank you to all participants and congratulations to the organizing team, who brought to life a fantastic event!👏
@strphy.bsky.social
#StrPhy26
APSPM brought together researchers from around the world to explore protein evolution from different angles. Structural approaches are reshaping evolutionary inference and the community is growing. Huge thanks to participants and @official-smbe.bsky.social for making this meeting a success.
#StryPhy
#StryPhy
February 23, 2026 at 10:22 PM
APSPM brought together researchers from around the world to explore protein evolution from different angles. Structural approaches are reshaping evolutionary inference and the community is growing. Huge thanks to participants and @official-smbe.bsky.social for making this meeting a success.
#StryPhy
#StryPhy
APSPM2026 - What can we learn from ancient protein history?
@joannamasel.bsky.social will open with her research tracing how the genetic code first evolved and the surprising origin of tryptophan.
@official-smbe.bsky.social
#StrPhy26 #StrPhy
@joannamasel.bsky.social will open with her research tracing how the genetic code first evolved and the surprising origin of tryptophan.
@official-smbe.bsky.social
#StrPhy26 #StrPhy
February 17, 2026 at 9:06 PM
APSPM2026 - What can we learn from ancient protein history?
@joannamasel.bsky.social will open with her research tracing how the genetic code first evolved and the surprising origin of tryptophan.
@official-smbe.bsky.social
#StrPhy26 #StrPhy
@joannamasel.bsky.social will open with her research tracing how the genetic code first evolved and the surprising origin of tryptophan.
@official-smbe.bsky.social
#StrPhy26 #StrPhy
Thank you @fabianruperti.bsky.social for sharing your research with us today. It sparked timely and interesting conversations.
#StrPhy26
#StrPhy26
Talking about structure-based protein annotations in weid critters (or „Why we shouldn’t say ‘structural homolog’!”). Thanks for having me @strphy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics
February 17, 2026 at 8:05 AM
Thank you @fabianruperti.bsky.social for sharing your research with us today. It sparked timely and interesting conversations.
#StrPhy26
#StrPhy26
APSPM2026 #StrPhy26
Amazing talk by @martinsteinegger.bsky.social at the #StructuralPhylogenetics meeting in Brisbane @strphy.bsky.social
The meeting is going to be live for the next 2 days. Excited to see what happens next. #Evolution
The meeting is going to be live for the next 2 days. Excited to see what happens next. #Evolution
February 16, 2026 at 10:31 PM
APSPM2026 #StrPhy26
APSPM2026 - Today's session starts with @claudiaalcar.bsky.social
Charting the protein universe: Deep evolutionary signals in sequence structure space (remote).
She'll present her work on exploring how protein folds emerged and diversified over billions of years.
#StrPhy26 #StrPhy
Charting the protein universe: Deep evolutionary signals in sequence structure space (remote).
She'll present her work on exploring how protein folds emerged and diversified over billions of years.
#StrPhy26 #StrPhy
February 16, 2026 at 10:30 PM
APSPM2026 - Today's session starts with @claudiaalcar.bsky.social
Charting the protein universe: Deep evolutionary signals in sequence structure space (remote).
She'll present her work on exploring how protein folds emerged and diversified over billions of years.
#StrPhy26 #StrPhy
Charting the protein universe: Deep evolutionary signals in sequence structure space (remote).
She'll present her work on exploring how protein folds emerged and diversified over billions of years.
#StrPhy26 #StrPhy
Biochemistry Alumni Lecture –APSPM 2026
Mon 16 Feb 14:30–15:30
Exploring the Protein Universe with Multimers, Motifs & Interfaces @martinsteinegger.bsky.social will present their fast computational methods to search and cluster across these structural layers. From structure to function to evolution.
Mon 16 Feb 14:30–15:30
Exploring the Protein Universe with Multimers, Motifs & Interfaces @martinsteinegger.bsky.social will present their fast computational methods to search and cluster across these structural layers. From structure to function to evolution.
February 15, 2026 at 1:03 AM
Biochemistry Alumni Lecture –APSPM 2026
Mon 16 Feb 14:30–15:30
Exploring the Protein Universe with Multimers, Motifs & Interfaces @martinsteinegger.bsky.social will present their fast computational methods to search and cluster across these structural layers. From structure to function to evolution.
Mon 16 Feb 14:30–15:30
Exploring the Protein Universe with Multimers, Motifs & Interfaces @martinsteinegger.bsky.social will present their fast computational methods to search and cluster across these structural layers. From structure to function to evolution.
Opening plenary APSPM 2026: Protein structure characters in the light of phylogenetic systematics by @nicholasmatzke.bsky.social A thought-provoking talk that revisits classic systematics concepts to address the question: are structural differences evolutionary signals or methodological artefacts?
February 15, 2026 at 12:46 AM
Opening plenary APSPM 2026: Protein structure characters in the light of phylogenetic systematics by @nicholasmatzke.bsky.social A thought-provoking talk that revisits classic systematics concepts to address the question: are structural differences evolutionary signals or methodological artefacts?
Meet the APSPM 2026 organisers: Caroline, Jordan and Ashar. We're 3 ECRs based in Australia/NZ passionate about protein evolution and developing new approaches and applications to advance this exciting field.
biosig.lab.uq.edu.au/strphy26/org...
@official-smbe.bsky.social
biosig.lab.uq.edu.au/strphy26/org...
@official-smbe.bsky.social
February 13, 2026 at 12:12 AM
Meet the APSPM 2026 organisers: Caroline, Jordan and Ashar. We're 3 ECRs based in Australia/NZ passionate about protein evolution and developing new approaches and applications to advance this exciting field.
biosig.lab.uq.edu.au/strphy26/org...
@official-smbe.bsky.social
biosig.lab.uq.edu.au/strphy26/org...
@official-smbe.bsky.social
Only 3 days to go before APSPM 2026 starts! In-person attendees, we'd love for you to join us for drinks and nibbles by the riverside on Sunday, Feb 15 at 5.30pm at Southbank Beer Garden. See you there!
www.southbankbeergarden.com.au
www.southbankbeergarden.com.au
February 12, 2026 at 11:39 PM
Only 3 days to go before APSPM 2026 starts! In-person attendees, we'd love for you to join us for drinks and nibbles by the riverside on Sunday, Feb 15 at 5.30pm at Southbank Beer Garden. See you there!
www.southbankbeergarden.com.au
www.southbankbeergarden.com.au
Reposted by Structural Phylogenetics (StrPhy)
The program is now live. An excellent global lineup of speakers - AUS, NZ, Korea, India, Laos, UK, Switzerland, France, Finland, Germany, Hungary, Japan, Uruguay, Mexico and USA. Browse abstracts. Just 3 weeks left. Super excited.
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
The program for the SMBE Australasian Protein Structural Phylogenetics Meeting 2026 is now out! Abstract book coming soon.
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
January 26, 2026 at 9:36 AM
The program is now live. An excellent global lineup of speakers - AUS, NZ, Korea, India, Laos, UK, Switzerland, France, Finland, Germany, Hungary, Japan, Uruguay, Mexico and USA. Browse abstracts. Just 3 weeks left. Super excited.
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
The program for the SMBE Australasian Protein Structural Phylogenetics Meeting 2026 is now out! Abstract book coming soon.
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
January 26, 2026 at 9:16 AM
The program for the SMBE Australasian Protein Structural Phylogenetics Meeting 2026 is now out! Abstract book coming soon.
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
@official-smbe.bsky.social @proteinmechanic.bsky.social
biosig.lab.uq.edu.au/strphy26/pro...
One month to go until APSPM 2026!
Scientific program coming soon.
Scientific program coming soon.
January 15, 2026 at 5:25 AM
One month to go until APSPM 2026!
Scientific program coming soon.
Scientific program coming soon.
Reposted by Structural Phylogenetics (StrPhy)
An interesting way to look at encoded structural characters to build alignments and trees downstream. This takes structural phylogenetics one step further in the post-AlphaFold era.
#Evolution #Science #StrPhy
On Confidence Assessment in Structure-Aware Alignments
doi.org/10.1093/gbe/...
#Evolution #Science #StrPhy
On Confidence Assessment in Structure-Aware Alignments
doi.org/10.1093/gbe/...
Structome-AlignViewer: On Confidence Assessment in Structure-Aware Alignments
Abstract. Protein structure-based comparison provides a framework for uncovering deep evolutionary relationships that can escape conventional sequence-base
doi.org
January 14, 2026 at 11:07 AM
An interesting way to look at encoded structural characters to build alignments and trees downstream. This takes structural phylogenetics one step further in the post-AlphaFold era.
#Evolution #Science #StrPhy
On Confidence Assessment in Structure-Aware Alignments
doi.org/10.1093/gbe/...
#Evolution #Science #StrPhy
On Confidence Assessment in Structure-Aware Alignments
doi.org/10.1093/gbe/...
We have reached full capacity for in-person attendance at #APSPM2026 and registration is now closed. Thanks to everyone who registered. Accepted talks and travel grants will be announced in the upcoming weeks.
November 28, 2025 at 10:22 AM
We have reached full capacity for in-person attendance at #APSPM2026 and registration is now closed. Thanks to everyone who registered. Accepted talks and travel grants will be announced in the upcoming weeks.
We have had an amazing response to #APSPM2026 and only a few in person spots are still available.
Abstract submissions and travel grant applications close tomorrow November 28.
👉 biosig.lab.uq.edu.au/strphy26/reg...
Join the community that is transforming protein evolution research.
Abstract submissions and travel grant applications close tomorrow November 28.
👉 biosig.lab.uq.edu.au/strphy26/reg...
Join the community that is transforming protein evolution research.
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
November 27, 2025 at 4:01 AM
We have had an amazing response to #APSPM2026 and only a few in person spots are still available.
Abstract submissions and travel grant applications close tomorrow November 28.
👉 biosig.lab.uq.edu.au/strphy26/reg...
Join the community that is transforming protein evolution research.
Abstract submissions and travel grant applications close tomorrow November 28.
👉 biosig.lab.uq.edu.au/strphy26/reg...
Join the community that is transforming protein evolution research.
Reposted by Structural Phylogenetics (StrPhy)
SMBE Australasian Protein Structural Phylogenetics Meeting
📄 Abstract submission deadline: Nov 28
Please submit your abstracts by Friday! Registration is free, but limited to 50 in-person attendees.
✈️ Travel grant applications deadline: Nov 28
🔗 biosig.lab.uq.edu.au/strphy26/str...
📄 Abstract submission deadline: Nov 28
Please submit your abstracts by Friday! Registration is free, but limited to 50 in-person attendees.
✈️ Travel grant applications deadline: Nov 28
🔗 biosig.lab.uq.edu.au/strphy26/str...
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
November 24, 2025 at 6:09 AM
SMBE Australasian Protein Structural Phylogenetics Meeting
📄 Abstract submission deadline: Nov 28
Please submit your abstracts by Friday! Registration is free, but limited to 50 in-person attendees.
✈️ Travel grant applications deadline: Nov 28
🔗 biosig.lab.uq.edu.au/strphy26/str...
📄 Abstract submission deadline: Nov 28
Please submit your abstracts by Friday! Registration is free, but limited to 50 in-person attendees.
✈️ Travel grant applications deadline: Nov 28
🔗 biosig.lab.uq.edu.au/strphy26/str...
Registration for #APSPM2026 closes soon.
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
November 23, 2025 at 10:03 PM
Registration for #APSPM2026 closes soon.
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Everyone’s welcome! whether you study evolution, structure, or computational methods, join us in Brisbane (and online) Feb 16–18, 2026 to learn how protein structure meets phylogenetics.
biosig.lab.uq.edu.au/strphy26
@official-smbe.bsky.social
Reposted by Structural Phylogenetics (StrPhy)
From AI to ancestral proteins, the #APSPM2026 speaker lineup brings protein evolution research together in one place. Check out the list of confirmed speakers here:
biosig.lab.uq.edu.au/strphy26/spe...
Brisbane + online
Feb 2026
Free registration
@official-smbe.bsky.social
biosig.lab.uq.edu.au/strphy26/spe...
Brisbane + online
Feb 2026
Free registration
@official-smbe.bsky.social
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
November 14, 2025 at 4:58 AM
From AI to ancestral proteins, the #APSPM2026 speaker lineup brings protein evolution research together in one place. Check out the list of confirmed speakers here:
biosig.lab.uq.edu.au/strphy26/spe...
Brisbane + online
Feb 2026
Free registration
@official-smbe.bsky.social
biosig.lab.uq.edu.au/strphy26/spe...
Brisbane + online
Feb 2026
Free registration
@official-smbe.bsky.social
Meet the plenary speakers for #APSPM2026.
Joanna Masel @joannamasel.bsky.social
Nicholas Matzke @nicholasmatzke.bsky.social
Join us to discuss how protein structure is changing evolutionary theory, phylogenetics and molecular evolution.
biosig.lab.uq.edu.au/strphy26/spe...
Joanna Masel @joannamasel.bsky.social
Nicholas Matzke @nicholasmatzke.bsky.social
Join us to discuss how protein structure is changing evolutionary theory, phylogenetics and molecular evolution.
biosig.lab.uq.edu.au/strphy26/spe...
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
November 14, 2025 at 2:23 AM
Meet the plenary speakers for #APSPM2026.
Joanna Masel @joannamasel.bsky.social
Nicholas Matzke @nicholasmatzke.bsky.social
Join us to discuss how protein structure is changing evolutionary theory, phylogenetics and molecular evolution.
biosig.lab.uq.edu.au/strphy26/spe...
Joanna Masel @joannamasel.bsky.social
Nicholas Matzke @nicholasmatzke.bsky.social
Join us to discuss how protein structure is changing evolutionary theory, phylogenetics and molecular evolution.
biosig.lab.uq.edu.au/strphy26/spe...
Reposted by Structural Phylogenetics (StrPhy)
Structure-informed phylogenetic inference with FoldTree outperforms sequence-only trees on divergent proteins, and untangles RRNPPA quorum-sensing receptors across Gram-positive bacteria & phages. Work led by David Moi (www.linkedin.com/in/david-moi) Paper: doi.org/10.1038/s415...
October 23, 2025 at 6:13 AM
Structure-informed phylogenetic inference with FoldTree outperforms sequence-only trees on divergent proteins, and untangles RRNPPA quorum-sensing receptors across Gram-positive bacteria & phages. Work led by David Moi (www.linkedin.com/in/david-moi) Paper: doi.org/10.1038/s415...
Reposted by Structural Phylogenetics (StrPhy)
Viral protein sequences are highly variable, but structures are much more conserved.
In this paper, David Moi et al. present a highly accurate method to infer phylogenetic trees from 3D protein structures — opening new ways to explore viral evolution and protein function.
In this paper, David Moi et al. present a highly accurate method to infer phylogenetic trees from 3D protein structures — opening new ways to explore viral evolution and protein function.
Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses - Nature Structural & Molecular Biology
Using a new method called FoldTree, the authors compare proteins on the basis of their shape to construct more accurate family trees over long evolutionary timescales and capture distant relationships...
www.nature.com
November 4, 2025 at 2:51 PM
Viral protein sequences are highly variable, but structures are much more conserved.
In this paper, David Moi et al. present a highly accurate method to infer phylogenetic trees from 3D protein structures — opening new ways to explore viral evolution and protein function.
In this paper, David Moi et al. present a highly accurate method to infer phylogenetic trees from 3D protein structures — opening new ways to explore viral evolution and protein function.
Reposted by Structural Phylogenetics (StrPhy)
We have had some amazing abstracts submitted to the free
@official-smbe.bsky.social APSPM meeting. To help you make up your mind, here is a sneak peek. Join for what will be an amazing meeting. biosig.lab.uq.edu.au/strphy26/sneakpeek/ . #StrPhy26 @strphy.bsky.social #Evolution #Science
@official-smbe.bsky.social APSPM meeting. To help you make up your mind, here is a sneak peek. Join for what will be an amazing meeting. biosig.lab.uq.edu.au/strphy26/sneakpeek/ . #StrPhy26 @strphy.bsky.social #Evolution #Science
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
November 3, 2025 at 4:21 AM
We have had some amazing abstracts submitted to the free
@official-smbe.bsky.social APSPM meeting. To help you make up your mind, here is a sneak peek. Join for what will be an amazing meeting. biosig.lab.uq.edu.au/strphy26/sneakpeek/ . #StrPhy26 @strphy.bsky.social #Evolution #Science
@official-smbe.bsky.social APSPM meeting. To help you make up your mind, here is a sneak peek. Join for what will be an amazing meeting. biosig.lab.uq.edu.au/strphy26/sneakpeek/ . #StrPhy26 @strphy.bsky.social #Evolution #Science
Reposted by Structural Phylogenetics (StrPhy)
February 2026 is shaping up to be the month for protein science down under!
Lorne (Feb 8–12) @lorneproteins.bsky.social
APSPM 2026, Brisbane (Feb 15–18)
biosig.lab.uq.edu.au/strphy26/str...
Two meetings and a summer of great science!
@strphy.bsky.social
@official-smbe.bsky.social
Lorne (Feb 8–12) @lorneproteins.bsky.social
APSPM 2026, Brisbane (Feb 15–18)
biosig.lab.uq.edu.au/strphy26/str...
Two meetings and a summer of great science!
@strphy.bsky.social
@official-smbe.bsky.social
October 30, 2025 at 3:49 AM
February 2026 is shaping up to be the month for protein science down under!
Lorne (Feb 8–12) @lorneproteins.bsky.social
APSPM 2026, Brisbane (Feb 15–18)
biosig.lab.uq.edu.au/strphy26/str...
Two meetings and a summer of great science!
@strphy.bsky.social
@official-smbe.bsky.social
Lorne (Feb 8–12) @lorneproteins.bsky.social
APSPM 2026, Brisbane (Feb 15–18)
biosig.lab.uq.edu.au/strphy26/str...
Two meetings and a summer of great science!
@strphy.bsky.social
@official-smbe.bsky.social
#APSPM2026 is open to anyone curious about combining protein structure and evolution. Learn where to start in our workshops and discover how structure meets phylogenetics.
Feb 15 - 18, 2026
Brisbane, Australia
Register here: biosig.lab.uq.edu.au/strphy26/reg...
(in-person only)
Feb 15 - 18, 2026
Brisbane, Australia
Register here: biosig.lab.uq.edu.au/strphy26/reg...
(in-person only)
October 30, 2025 at 12:55 AM
#APSPM2026 is open to anyone curious about combining protein structure and evolution. Learn where to start in our workshops and discover how structure meets phylogenetics.
Feb 15 - 18, 2026
Brisbane, Australia
Register here: biosig.lab.uq.edu.au/strphy26/reg...
(in-person only)
Feb 15 - 18, 2026
Brisbane, Australia
Register here: biosig.lab.uq.edu.au/strphy26/reg...
(in-person only)