Synthesis Workshop
@synthesisworkshop.bsky.social
An open access content creation initiative in chemistry, featuring video podcast episodes, courses, problem sets, virtual research posters, and more. Homepage: synthesis-workshop.com
Tune in this week as Mauro Mato shares his work on a photoredox strategy for unmasking C-H bonds!
Link: youtu.be/VW2X6KeLiFY
Key paper:
@jacs.acspublications.org 2026, 148, 5946–5952
doi.org/10.1021/jacs...
Thanks to Kathleen for editing and hosting!
Link: youtu.be/VW2X6KeLiFY
Key paper:
@jacs.acspublications.org 2026, 148, 5946–5952
doi.org/10.1021/jacs...
Thanks to Kathleen for editing and hosting!
September 11, 2026 at 8:24 PM
Tune in this week as Mauro Mato shares his work on a photoredox strategy for unmasking C-H bonds!
Link: youtu.be/VW2X6KeLiFY
Key paper:
@jacs.acspublications.org 2026, 148, 5946–5952
doi.org/10.1021/jacs...
Thanks to Kathleen for editing and hosting!
Link: youtu.be/VW2X6KeLiFY
Key paper:
@jacs.acspublications.org 2026, 148, 5946–5952
doi.org/10.1021/jacs...
Thanks to Kathleen for editing and hosting!
Today we are joined by Dr. Alexander Düfert, who discusses with us his new book, Methods of Organic Synthesis in a talk followed by a Q&A session with our editorial board!
Link: youtu.be/ctVRA18Wwcc
@springernature.com: link.springer.com/book/10.1007...
Thanks to Alicia for hosting!
Link: youtu.be/ctVRA18Wwcc
@springernature.com: link.springer.com/book/10.1007...
Thanks to Alicia for hosting!
August 29, 2026 at 2:53 PM
Today we are joined by Dr. Alexander Düfert, who discusses with us his new book, Methods of Organic Synthesis in a talk followed by a Q&A session with our editorial board!
Link: youtu.be/ctVRA18Wwcc
@springernature.com: link.springer.com/book/10.1007...
Thanks to Alicia for hosting!
Link: youtu.be/ctVRA18Wwcc
@springernature.com: link.springer.com/book/10.1007...
Thanks to Alicia for hosting!
This week we are excited to present our August ChemDev poster, focusing on the development of a manufacturing process for the COVID-19 antiviral ensitrelvir! This poster is brought to you by our Associate Editor of ChemDev Posters, Violet YJ Chen!
Key reference: doi.org/10.1021/acsc...
Key reference: doi.org/10.1021/acsc...
August 1, 2026 at 1:58 PM
This week we are excited to present our August ChemDev poster, focusing on the development of a manufacturing process for the COVID-19 antiviral ensitrelvir! This poster is brought to you by our Associate Editor of ChemDev Posters, Violet YJ Chen!
Key reference: doi.org/10.1021/acsc...
Key reference: doi.org/10.1021/acsc...
This week Violet YJ Chen highlights the development of a manufacturing process for a key intermediate of orforglipron (a non-peptide GLP-1 receptor agonist) by the team at Lilly!
Key papers:
doi.org/10.1021/acs....
doi.org/10.1021/acs....
doi.org/10.1021/acs....
Key papers:
doi.org/10.1021/acs....
doi.org/10.1021/acs....
doi.org/10.1021/acs....
July 5, 2026 at 2:11 PM
This week Violet YJ Chen highlights the development of a manufacturing process for a key intermediate of orforglipron (a non-peptide GLP-1 receptor agonist) by the team at Lilly!
Key papers:
doi.org/10.1021/acs....
doi.org/10.1021/acs....
doi.org/10.1021/acs....
Key papers:
doi.org/10.1021/acs....
doi.org/10.1021/acs....
doi.org/10.1021/acs....
In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team!
Key paper: doi.org/10.1021/acs....
Key paper: doi.org/10.1021/acs....
June 6, 2026 at 7:26 PM
In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team!
Key paper: doi.org/10.1021/acs....
Key paper: doi.org/10.1021/acs....
Tune in today as Henrik Wilke joins us to share his work on the total synthesis of (±)-Dhilirolide U! Thanks to Alicia Wagner for hosting and editing!
Link: youtu.be/-pBrDNQZ_hU
@jacs.acspublications.org 2026, 148, 5916–5922.
doi.org/10.1021/jacs...
Link: youtu.be/-pBrDNQZ_hU
@jacs.acspublications.org 2026, 148, 5916–5922.
doi.org/10.1021/jacs...
Total Synthesis of (±)-Dhilirolide U with Henrik Wilke
YouTube video by Synthesis Workshop Videos
youtu.be
May 30, 2026 at 2:18 PM
Tune in today as Henrik Wilke joins us to share his work on the total synthesis of (±)-Dhilirolide U! Thanks to Alicia Wagner for hosting and editing!
Link: youtu.be/-pBrDNQZ_hU
@jacs.acspublications.org 2026, 148, 5916–5922.
doi.org/10.1021/jacs...
Link: youtu.be/-pBrDNQZ_hU
@jacs.acspublications.org 2026, 148, 5916–5922.
doi.org/10.1021/jacs...
Today Augustin "Gus" Péneau presents our ChemDev poster for May, featuring a convergent synthesis of GNE-6893 by the small molecule process team at Genentech!
For more details check out the papers here:
doi.org/10.1021/acs....
doi.org/10.1021/acsm...
@acs.org
For more details check out the papers here:
doi.org/10.1021/acs....
doi.org/10.1021/acsm...
@acs.org
May 9, 2026 at 2:06 PM
Today Augustin "Gus" Péneau presents our ChemDev poster for May, featuring a convergent synthesis of GNE-6893 by the small molecule process team at Genentech!
For more details check out the papers here:
doi.org/10.1021/acs....
doi.org/10.1021/acsm...
@acs.org
For more details check out the papers here:
doi.org/10.1021/acs....
doi.org/10.1021/acsm...
@acs.org
Tune in this week as Dr. Charis Amber @sarponggroup.bsky.social shares his work on the development of an "inside-out" strategy. for the synthesis of hispidospermidin!
Link: youtu.be/Rtjb79JtvIE
JACS Au 2026, 6, 600–606.
doi.org/10.1021/jacs...
Link: youtu.be/Rtjb79JtvIE
JACS Au 2026, 6, 600–606.
doi.org/10.1021/jacs...
An ”Inside-out” Strategy Enables a 14-Step Total Synthesis of Hispidospermidin with Dr. Charis Amber
YouTube video by Synthesis Workshop Videos
youtu.be
May 2, 2026 at 2:15 PM
Tune in this week as Dr. Charis Amber @sarponggroup.bsky.social shares his work on the development of an "inside-out" strategy. for the synthesis of hispidospermidin!
Link: youtu.be/Rtjb79JtvIE
JACS Au 2026, 6, 600–606.
doi.org/10.1021/jacs...
Link: youtu.be/Rtjb79JtvIE
JACS Au 2026, 6, 600–606.
doi.org/10.1021/jacs...
Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College!
Link: youtu.be/UE-S8R3zd60
Key paper:
@jacs.acspublications.org 2026, 148, 3944-3948.
doi.org/10.1021/jacs...
Link: youtu.be/UE-S8R3zd60
Key paper:
@jacs.acspublications.org 2026, 148, 3944-3948.
doi.org/10.1021/jacs...
April 11, 2026 at 2:25 PM
Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College!
Link: youtu.be/UE-S8R3zd60
Key paper:
@jacs.acspublications.org 2026, 148, 3944-3948.
doi.org/10.1021/jacs...
Link: youtu.be/UE-S8R3zd60
Key paper:
@jacs.acspublications.org 2026, 148, 3944-3948.
doi.org/10.1021/jacs...
This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor!
Key paper:
Org. Process Res. Dev. 2024, 28, 8, 3229–3247
doi.org/10.1021/acs....
Key paper:
Org. Process Res. Dev. 2024, 28, 8, 3229–3247
doi.org/10.1021/acs....
April 4, 2026 at 1:52 PM
This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor!
Key paper:
Org. Process Res. Dev. 2024, 28, 8, 3229–3247
doi.org/10.1021/acs....
Key paper:
Org. Process Res. Dev. 2024, 28, 8, 3229–3247
doi.org/10.1021/acs....
Join us this week on Synthesis Workshop as Stanislav Melnikov shares his work on the role of quantum tunneling in metal-ligand proton tautomerism!
Link: youtu.be/4hnNuJDdI8Q
Key paper:
@jacs.acspublications.org 2026, 147, 50, 46324–46335.
doi.org/10.1021/jacs...
Link: youtu.be/4hnNuJDdI8Q
Key paper:
@jacs.acspublications.org 2026, 147, 50, 46324–46335.
doi.org/10.1021/jacs...
The Role of Quantum Tunneling in Metal-ligand Proton Tautomerism with Stanislav Melnikov
YouTube video by Synthesis Workshop Videos
youtu.be
March 14, 2026 at 2:48 PM
Join us this week on Synthesis Workshop as Stanislav Melnikov shares his work on the role of quantum tunneling in metal-ligand proton tautomerism!
Link: youtu.be/4hnNuJDdI8Q
Key paper:
@jacs.acspublications.org 2026, 147, 50, 46324–46335.
doi.org/10.1021/jacs...
Link: youtu.be/4hnNuJDdI8Q
Key paper:
@jacs.acspublications.org 2026, 147, 50, 46324–46335.
doi.org/10.1021/jacs...
Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!
March 7, 2026 at 8:50 PM
Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!
Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!!
Link: youtu.be/S2NS3sL6_g0
Key paper:
ACS Catal. 2026, 16, 1, 203–210.
doi.org/10.1021/acsc...
Link: youtu.be/S2NS3sL6_g0
Key paper:
ACS Catal. 2026, 16, 1, 203–210.
doi.org/10.1021/acsc...
February 14, 2026 at 2:51 PM
Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!!
Link: youtu.be/S2NS3sL6_g0
Key paper:
ACS Catal. 2026, 16, 1, 203–210.
doi.org/10.1021/acsc...
Link: youtu.be/S2NS3sL6_g0
Key paper:
ACS Catal. 2026, 16, 1, 203–210.
doi.org/10.1021/acsc...
Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!!
Link: youtu.be/-4ggoK4ACUk
Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...
Thanks to Dr. Alicia Wagner for hosting!
Link: youtu.be/-4ggoK4ACUk
Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...
Thanks to Dr. Alicia Wagner for hosting!
Ligand Design for Light-driven Nickel Catalysis with Dr. Lucia Anghileri
YouTube video by Synthesis Workshop Videos
youtu.be
January 31, 2026 at 3:09 PM
Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!!
Link: youtu.be/-4ggoK4ACUk
Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...
Thanks to Dr. Alicia Wagner for hosting!
Link: youtu.be/-4ggoK4ACUk
Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...
Thanks to Dr. Alicia Wagner for hosting!
Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!!
Link: youtu.be/Gh1qxy7Z7K0
@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...
Thanks to Kathleen for hosting!
Link: youtu.be/Gh1qxy7Z7K0
@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...
Thanks to Kathleen for hosting!
January 24, 2026 at 8:36 PM
Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!!
Link: youtu.be/Gh1qxy7Z7K0
@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...
Thanks to Kathleen for hosting!
Link: youtu.be/Gh1qxy7Z7K0
@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...
Thanks to Kathleen for hosting!
Reposted by Synthesis Workshop
Another fantastic Chemical Science paper being highlighted by @synthesisworkshop.bsky.social!
Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!
Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!
January 23, 2026 at 12:11 PM
Another fantastic Chemical Science paper being highlighted by @synthesisworkshop.bsky.social!
Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!
Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!
Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!!
Link: youtu.be/rhhpewmsRBc
Big thanks to Reem for hosting and editing!
Link: youtu.be/rhhpewmsRBc
Big thanks to Reem for hosting and editing!
Bio-inspired Total Synthesis of Daphnepapytone A with Joan Pereira
YouTube video by Synthesis Workshop Videos
youtu.be
January 17, 2026 at 8:29 PM
Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!!
Link: youtu.be/rhhpewmsRBc
Big thanks to Reem for hosting and editing!
Link: youtu.be/rhhpewmsRBc
Big thanks to Reem for hosting and editing!
Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!!
Link: youtu.be/EVtEZwUSrbU
@jacs.acspublications.org doi.org/10.1021/jacs...
Link: youtu.be/EVtEZwUSrbU
@jacs.acspublications.org doi.org/10.1021/jacs...
January 3, 2026 at 2:45 PM
Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!!
Link: youtu.be/EVtEZwUSrbU
@jacs.acspublications.org doi.org/10.1021/jacs...
Link: youtu.be/EVtEZwUSrbU
@jacs.acspublications.org doi.org/10.1021/jacs...
Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting!
Link: youtu.be/2InU6iFBYFQ
Nature 2025, 644, 96–101.
doi.org/10.1038/s415...
Link: youtu.be/2InU6iFBYFQ
Nature 2025, 644, 96–101.
doi.org/10.1038/s415...
Redox-powered Autonomous Directional C–C Bond Rotation Under Enzyme Control with Jordan Berreur
YouTube video by Synthesis Workshop Videos
youtu.be
December 21, 2025 at 6:06 PM
Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting!
Link: youtu.be/2InU6iFBYFQ
Nature 2025, 644, 96–101.
doi.org/10.1038/s415...
Link: youtu.be/2InU6iFBYFQ
Nature 2025, 644, 96–101.
doi.org/10.1038/s415...
Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!!
Link: youtu.be/BDuyOmrTsqI
Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w
Link: youtu.be/BDuyOmrTsqI
Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w
Introduction to Prebiotic Chemistry: Prebiotic Peptide Synthesis with Dr. Benji Thoma
YouTube video by Synthesis Workshop Videos
youtu.be
December 13, 2025 at 3:17 PM
Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!!
Link: youtu.be/BDuyOmrTsqI
Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w
Link: youtu.be/BDuyOmrTsqI
Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w
Curious to hear the story behind this paper?
doi.org/10.1021/jacs...
Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE
@jacs.acspublications.org
doi.org/10.1021/jacs...
Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE
@jacs.acspublications.org
Cyclic Bifunctional Reagents Enabling a Strain-Release-Driven Formal [3 + 2] Cycloaddition of 2H-Azirines by Cascade Energy Transfer
The energy transfer (EnT)-catalyzed ring opening and further decarboxylation of isoxazole-5(4H)-ones enables the in situ generation of strained 2H-azirines. Subsequent selective C(sp2)–C(sp3) bond cle...
doi.org
December 6, 2025 at 3:12 PM
Curious to hear the story behind this paper?
doi.org/10.1021/jacs...
Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE
@jacs.acspublications.org
doi.org/10.1021/jacs...
Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE
@jacs.acspublications.org
Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing!
Link: youtu.be/k2nOfYnNk6U
Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...
Thanks to Karim for hosting!!
Link: youtu.be/k2nOfYnNk6U
Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...
Thanks to Karim for hosting!!
November 29, 2025 at 8:37 PM
Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing!
Link: youtu.be/k2nOfYnNk6U
Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...
Thanks to Karim for hosting!!
Link: youtu.be/k2nOfYnNk6U
Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...
Thanks to Karim for hosting!!
Reposted by Synthesis Workshop
🔬 You know a young innovator in #organicsynthesis? Great!
Nominate them for the Thieme–IUPAC Prize 2026!
🎖️ €5,000 prize
📩 Deadline: Dec 12, 2025
📤 Send to: [email protected]
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social
Nominate them for the Thieme–IUPAC Prize 2026!
🎖️ €5,000 prize
📩 Deadline: Dec 12, 2025
📤 Send to: [email protected]
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social
November 25, 2025 at 11:53 AM
🔬 You know a young innovator in #organicsynthesis? Great!
Nominate them for the Thieme–IUPAC Prize 2026!
🎖️ €5,000 prize
📩 Deadline: Dec 12, 2025
📤 Send to: [email protected]
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social
Nominate them for the Thieme–IUPAC Prize 2026!
🎖️ €5,000 prize
📩 Deadline: Dec 12, 2025
📤 Send to: [email protected]
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social
Reposted by Synthesis Workshop
Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky
Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
October 20, 2025 at 10:55 AM
Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky
Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
November 8, 2025 at 3:52 PM
Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.