The Ott Lab
@theottlab.bsky.social
Melanie Ott's lab @ Gladstone Institutes studying host-viral pathogen interactions. Posts from lab members. Reposts are not endorsements.
Reposted by The Ott Lab
New research emerging from the COVID-19 pandemic is revealing surprising connections between viruses, inflammation, and cancer progression. Gladstone Investigator Melanie Ott comments on these findings in the LA Times.
@theottlab.bsky.social
@theottlab.bsky.social
What COVID is teaching doctors about the relationship between viruses and cancer
The pandemic has left some evidence that viral infection may play a role in reawakening dormant cancer cells already present in a patient's body before infection.
www.latimes.com
June 19, 2026 at 8:19 PM
New research emerging from the COVID-19 pandemic is revealing surprising connections between viruses, inflammation, and cancer progression. Gladstone Investigator Melanie Ott comments on these findings in the LA Times.
@theottlab.bsky.social
@theottlab.bsky.social
Reposted by The Ott Lab
A team of Gladstone scientists—including Katie Pollard, Melanie Ott, Seth Shipman, and Sukrit Silas—will lead one of three new national centers dedicated to accelerating the development of phage therapy.
@theottlab.bsky.social
@seth-shipman.bsky.social
@theottlab.bsky.social
@seth-shipman.bsky.social
Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections
The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.
gladstone.org
June 2, 2026 at 9:40 PM
A team of Gladstone scientists—including Katie Pollard, Melanie Ott, Seth Shipman, and Sukrit Silas—will lead one of three new national centers dedicated to accelerating the development of phage therapy.
@theottlab.bsky.social
@seth-shipman.bsky.social
@theottlab.bsky.social
@seth-shipman.bsky.social
Reposted by The Ott Lab
We're launching a major collaborative Center aimed at accelerating phage therapy @gladstoneinst.bsky.social. High-throughput experiments with engineered phages (my lab) and strains (Silas Lab), organoids (Ott Lab), and AI (Pollard Lab).
gladstone.org/news/gladsto...
gladstone.org/news/gladsto...
Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections
The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.
gladstone.org
June 2, 2026 at 9:29 PM
We're launching a major collaborative Center aimed at accelerating phage therapy @gladstoneinst.bsky.social. High-throughput experiments with engineered phages (my lab) and strains (Silas Lab), organoids (Ott Lab), and AI (Pollard Lab).
gladstone.org/news/gladsto...
gladstone.org/news/gladsto...
Reposted by The Ott Lab
🚨 NEW PUBLICATION🚨 "Programmable kinetic barcoding for multiplexed RNA detection with Cas13a"
@natbiomedeng.nature.com
@doudna-lab.bsky.social
@theottlab.bsky.social
https://www.nature.com/articles/s41551-026-01642-6
@natbiomedeng.nature.com
@doudna-lab.bsky.social
@theottlab.bsky.social
https://www.nature.com/articles/s41551-026-01642-6
Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering
A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...
www.nature.com
April 29, 2026 at 11:28 PM
🚨 NEW PUBLICATION🚨 "Programmable kinetic barcoding for multiplexed RNA detection with Cas13a"
@natbiomedeng.nature.com
@doudna-lab.bsky.social
@theottlab.bsky.social
https://www.nature.com/articles/s41551-026-01642-6
@natbiomedeng.nature.com
@doudna-lab.bsky.social
@theottlab.bsky.social
https://www.nature.com/articles/s41551-026-01642-6
Reposted by The Ott Lab
Cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound after ART interruption @cp-immunity.bsky.social @gladstoneinst.bsky.social #Roan @theottlab.bsky.social #Greene www.cell.com/immunity/ful...
March 20, 2026 at 3:52 PM
Cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound after ART interruption @cp-immunity.bsky.social @gladstoneinst.bsky.social #Roan @theottlab.bsky.social #Greene www.cell.com/immunity/ful...
Reposted by The Ott Lab
In our new work published in @natbiomedeng.nature.com in collaboration with @theottlab.bsky.social and @doudna-lab.bsky.social, we introduce "interfering" guide RNAs (igRNA) for CRISPR-Cas13a that regulate enzyme activity after activation. Congrats to all the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering
A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...
www.nature.com
April 2, 2026 at 4:17 PM
In our new work published in @natbiomedeng.nature.com in collaboration with @theottlab.bsky.social and @doudna-lab.bsky.social, we introduce "interfering" guide RNAs (igRNA) for CRISPR-Cas13a that regulate enzyme activity after activation. Congrats to all the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We honor the life of J. Michael Bishop, whose groundbreaking discoveries helped transform our understanding of cancer and opened new paths for treatment. His legacy will continue to inspire generations of scientists and clinicians. Rest in peace.
March 23, 2026 at 7:12 PM
We honor the life of J. Michael Bishop, whose groundbreaking discoveries helped transform our understanding of cancer and opened new paths for treatment. His legacy will continue to inspire generations of scientists and clinicians. Rest in peace.
Reposted by The Ott Lab
Antiretroviral therapy transformed #HIV care—now we need a cure. Insights from Melanie Ott on what comes next.
Virologist Viewpoints: For HIV, ‘Manageable' Is No Longer Good Enough
Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS.
bit.ly
March 4, 2026 at 6:13 PM
Antiretroviral therapy transformed #HIV care—now we need a cure. Insights from Melanie Ott on what comes next.
Congrats, Nadia!
Nadia Roan, a pioneer in the fight against some of the world’s most persistent viruses, has been elected as a 2026 Fellow of the American Academy of Microbiology.
Gladstone Scientist Nadia Roan Elected to American Academy of Microbiology
Roan has made great strides in understanding how persistent viruses including HIV cause disease and how immunity to viruses shapes human health.
gladstone.org
February 20, 2026 at 10:43 PM
Congrats, Nadia!
Reposted by The Ott Lab
🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...
bit.ly
December 2, 2025 at 6:31 PM
🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social
Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"!
📆 Monday, December 1, 2025 at 10am PT
📍 Live on TikTok via
@RaifDerrazi
🔗 Register: tiktok.com/live/event/7...
📆 Monday, December 1, 2025 at 10am PT
📍 Live on TikTok via
@RaifDerrazi
🔗 Register: tiktok.com/live/event/7...
November 24, 2025 at 11:06 PM
Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"!
📆 Monday, December 1, 2025 at 10am PT
📍 Live on TikTok via
@RaifDerrazi
🔗 Register: tiktok.com/live/event/7...
📆 Monday, December 1, 2025 at 10am PT
📍 Live on TikTok via
@RaifDerrazi
🔗 Register: tiktok.com/live/event/7...
The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-...
Beyond Viruses: Expanding the Fight Against Infectious Diseases
The newly renamed Gladstone Infectious Disease Institute broadens its mission to address global health threats ranging from antibiotic resistance to infections that cause chronic diseases.
gladstone.org
October 1, 2025 at 9:35 PM
The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-...
Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025...
With vaccine research under attack, it’s time for California to lead again
Halting mRNA research right now is like banning ChatGPT, writes infectious disease expert Melanie Ott — not just scientific negligence, but strategic self-sabotage.
sfstandard.com
August 14, 2025 at 5:38 PM
Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025...
Reposted by The Ott Lab
💉🧬 We're kicking off National Immunization Awareness Month with our faculty spotlight, Dr. Melanie Ott! Head to our Instagram to hear her take on how immunizations keep us safe—and how you can help to keep vaccines accessible for all: www.instagram.com/reel/DM_A9Sc...
@theottlab.bsky.social
@theottlab.bsky.social
August 5, 2025 at 7:24 PM
💉🧬 We're kicking off National Immunization Awareness Month with our faculty spotlight, Dr. Melanie Ott! Head to our Instagram to hear her take on how immunizations keep us safe—and how you can help to keep vaccines accessible for all: www.instagram.com/reel/DM_A9Sc...
@theottlab.bsky.social
@theottlab.bsky.social
Congratulations Fran! @franzapatero.bsky.social
Meet amfAR’s 2025 Mathilde Krim Fellows: Drs. Hastie, King, Ou & Zapatero Belinchon. As HIV research faces steep NIH cuts, amfAR is proud to back these bold young scientists and their innovative ideas. Learn more: www.amfar.org/news/new-amf...
amfAR Awards Boost Aspiring HIV Researchers
At a critical time for funding, amfAR awards four Mathilde Krim fellowships to early-career researchers studying innovative strategies to cure HIV.
www.amfar.org
July 29, 2025 at 5:51 PM
Congratulations Fran! @franzapatero.bsky.social
Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award!
cfar.ucsf.edu/user/11703
cfar.ucsf.edu/user/11703
Julia Prigann, PhD | UCSF-Bay Area Center for AIDS Research (CFAR)
cfar.ucsf.edu
July 17, 2025 at 5:16 PM
Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award!
cfar.ucsf.edu/user/11703
cfar.ucsf.edu/user/11703
We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXu...
authors.elsevier.com
June 11, 2025 at 5:41 PM
We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXu...
Reposted by The Ott Lab
Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics.
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Discovery Spotlight | Could This Molecule Be ‘Checkmate’ for Coronaviruses?
Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics. These molecules block a critical enzyme ne...
www.youtube.com
April 29, 2025 at 1:18 PM
Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics.
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Reposted by The Ott Lab
Scientists develop powerful drug candidates that could head off future coronavirus pandemics.
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Could This Molecule Be ‘Checkmate’ for Coronaviruses?
Scientists develop powerful drug candidates that could head off future coronavirus pandemics.
gladstone.org
April 23, 2025 at 8:54 PM
Scientists develop powerful drug candidates that could head off future coronavirus pandemics.
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Reposted by The Ott Lab
🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy"
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy
This study describes a class of potent, bioavailable SARS-CoV-2 MPro inhibitors having an unusual mechanism of inhibition.
www.science.org
April 24, 2025 at 3:02 PM
🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy"
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
@theottlab.bsky.social
@ucsfmedicine.bsky.social
@qbi-ucsf.bsky.social
Reposted by The Ott Lab
🎧 Listen to this podcast featuring virologist Melanie Ott. Ott discusses how measles works and the way it breaks into our body to make us sick.
@theottlab.bsky.social
@theottlab.bsky.social
How does measles make us sick?
And the damage left in its wake...
bit.ly
April 10, 2025 at 1:18 PM
🎧 Listen to this podcast featuring virologist Melanie Ott. Ott discusses how measles works and the way it breaks into our body to make us sick.
@theottlab.bsky.social
@theottlab.bsky.social
Thank you to everyone who attended the HIV Mini-Symposium on March 13th!
Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there!
www.youtube.com/watch?v=vjpe...
Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there!
www.youtube.com/watch?v=vjpe...
HIV Persistence: Where We Are Now and Where We Need to Go
YouTube video by QBI TV
www.youtube.com
March 28, 2025 at 4:30 PM
Thank you to everyone who attended the HIV Mini-Symposium on March 13th!
Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there!
www.youtube.com/watch?v=vjpe...
Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there!
www.youtube.com/watch?v=vjpe...
Reposted by The Ott Lab
Did you know that viruses don’t just infect humans—they also target bacteria in our microbiome? These viruses, called phages, play a crucial role in shaping our health and could be the key to fighting antibiotic-resistant bacteria.
In this short, @theottlab.bsky.social explains.
In this short, @theottlab.bsky.social explains.
March 26, 2025 at 1:20 PM
Did you know that viruses don’t just infect humans—they also target bacteria in our microbiome? These viruses, called phages, play a crucial role in shaping our health and could be the key to fighting antibiotic-resistant bacteria.
In this short, @theottlab.bsky.social explains.
In this short, @theottlab.bsky.social explains.
Reposted by The Ott Lab
Virologist Melanie Ott (@theottlab.bsky.social) speaks to KUSI News about the measles outbreak and other infectious diseases.
Gladstone's Dr. Melanie Ott speaks about measles, other infectious diseases on KUSI
buff.ly
March 20, 2025 at 1:18 PM
Virologist Melanie Ott (@theottlab.bsky.social) speaks to KUSI News about the measles outbreak and other infectious diseases.
Reposted by The Ott Lab
At Gladstone, researchers are working toward curing HIV for good. Their work also sheds light on how viruses influence our long-term health. Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology explains why curing HIV remains a crucial scientific challenge.
@theottlab.bsky.social
@theottlab.bsky.social
March 19, 2025 at 2:19 PM
At Gladstone, researchers are working toward curing HIV for good. Their work also sheds light on how viruses influence our long-term health. Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology explains why curing HIV remains a crucial scientific challenge.
@theottlab.bsky.social
@theottlab.bsky.social