Théophile Lambert
tlambert99.bsky.social
Théophile Lambert
@tlambert99.bsky.social
PhD Candidate in Co-supervision between Université Paris-Saclay and Caltech | Fulbright Scholar | Ecole Normale Supérieure de Lyon
Reposted by Théophile Lambert
What if AI could invent enzymes that nature hasn’t seen? 👩‍🔬🧑‍🔬

Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design

📝 Blog: disco-design.github.io
📄 Paper: arxiv.org/abs/2604.05181
💻 Code: github.com/DISCO-design...
April 8, 2026 at 3:47 PM
New work in Nature Communications! Using generative AI, we designed TrpB enzymes that are not only functional, but outperform natural ones and rival top lab-evolved TrpBs. www.nature.com/articles/s41...

Huge thanks to @francesarnold.bsky.social, @anima-anandkumar.bsky.social, and all co-authors!
February 17, 2026 at 9:43 PM