Tony Kelly
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tonykellyeu.bsky.social
Tony Kelly
@tonykellyeu.bsky.social
72 followers 92 following 18 posts
Bringing deep neuroscience and epilepsy domain expertise to data science
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tonykellyeu.bsky.social
Very happy our work on a weird new nanoscale morphological feature is out in @science.org. A massive effort involving different high resolution microscopy techniques, multiple institutes, & years of work to convince ourselves DENDRITIC NARROWINGS EXIST #neuroskyence 🧪 doi.org/10.1126/scia...
Dendritic shaft constrictions shape synaptic integration in neurons
For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2…
buff.ly
September 13, 2026 at 9:00 PM
Reposted by Tony Kelly
carandinilab.net
The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell.

A causal spatial role for apical dendrites in the cortex
www.biorxiv.org/content/10.6...

by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social
A cartoon providing a graphical summary of the paper. It is divided in 3 rows. The top row shows a pyramidal cell and its apical tuft, and shows the two experiments that we ran: optical dendritic pruning (chopping off the apical tuft), and synaptic imaging done in the same neurons where we do somatic imaging. The middle row shows the results pertaining to neurons that prefer large stimuli (this is visual cortex): pruning reduced their responses, and the receptive fields of apical synapses are far away from the that of the soma. The bottom row shows the results pertaining to neurons that prefer small stimuli: pruning seemed to do nothing to the responses, and the receptive field of apical synapses are right around that of the soma.
July 31, 2026 at 4:47 PM
tonykellyeu.bsky.social
Recently I referred to how dendritic compartmentalisation increases computation.
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
biological neuron is not same as point neuron
September 2, 2025 at 3:33 PM
tonykellyeu.bsky.social
Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology
https://doi.org/10.1101/2025.07.18.664460
August 30, 2025 at 8:14 PM
tonykellyeu.bsky.social
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
August 30, 2025 at 8:14 PM
tonykellyeu.bsky.social
Our @eLife paper on artefactual Ca2+ waves following calcium indicator expression is highlighted in neuroscience magazine @_TheTransmitter. Really nice talking with @avaskham and seeing the perspectives from @Sheffield_Lab, @DanielDombeck & @LoogerL https://t.co/vqy9K5hEeP
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
www.thetransmitter.org
August 30, 2025 at 8:13 PM
tonykellyeu.bsky.social
Nice work on how differences in dendritic morphology btwn human and mouse neurons impact dendritic excitability. https://x.com/GregStuartLab/status/1602900777328332800
August 30, 2025 at 8:12 PM