Today's paper presentation is about the paper „Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation“ of Almina Jukic et al. The paper is published in Gastroenterology. Have a look www.sciencedirect.com/science/arti...

Today's paper presentation is about the paper „Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice“ of Lena Erkert et al. The paper is published in Journal of CROHN´S and COLITIS. academic.oup.com/ecco-jcc/art...

Today's paper presentation is about the paper „ST6GAL1 promotes IBD B cell recruitment to the inflamed colon in a CD22-dependent mechanism“ of Lijuan Liu et al. The paper is published in Journal of CROHN´S and COLITIS. Feel free to have a look academic.oup.com/ecco-jcc/art...

In today´s #fluorescencefriday we see human colon with a lymphoid follicle stained for alpha smooth muscle actin, EpCAM, CD3 (T cells), CD20 (B cells), CD68 (macrophages) and CD11b (neutrophils and monocytes). In this image, fluorescent markers were played with -and forgot which ones they were.

Today's paper presentation is about the paper „The IL-22 oncostatin M axis promotes intestinal inflammation and tumorigenesis“ of Roodline Cineus et al. The paper is published in nature immunology. Feel free to have a look www.nature.com/articles/s41...

SEPIA is online 🎉
We are pleased to publish our SEPIA platform 🥳 You can access SEPIA via this link trr241.hosting.rrze.uni-erlangen.de/SEPIA/#!/

Today's paper presentation is about the paper „Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD “ of Miguel González Acera and Jay Patankar. The paper is published in Gut. Feel free to have a look. gut.bmj.com/content/earl...

New paper alert: Roodline Cineus et al. explore how the interaction between the cytokines interleukin-22 (IL-22) and oncostatin M (OSM) contributes to chronic intestinal inflammation and colitis-associated cancer (CAC)

www.nature.com/articles/s41...

Two amazing days at the TRR241 Symposium in Berlin just wrapped up! Great talks, inspiring discussions, and lots of fresh ideas – big thanks to everyone who joined and made it such a special event. A special thank you to our sponsors for their generous support!

#TRR241 #Symposium #Berlin #IBD

In today's #fluorescencefriday we see
human colon, stained for alpha-smooth muscle actin (smooth muscle, dark blue), CD3 (T cells, brown) and CD68 (macrophages, purple). The nuclei appear steel blue.

The image is provided by Dr. Anja Kühl.

Today's paper presentation is about the paper „Single-cell microbiota phenotyping reveals distinct disease and theraphy-associated signatures in Crohn´s disease “ of Lisa Budzinski. The paper is published in Gut Microbes. Feel free to have a look. DOI:10.1080/19490976.2025.2452250

🎉Congratulations to Susanne Krug on receiving a W2 endowed professorship for „Cell Biology and Pathophysiology of Intestinal Transport and Barrier Function“ at Charité – Universitätsmedizin Berlin, funded by the Sonnenfeld Foundation – their first ever funded professorship! 👏

Today's presentation is about the review „The intestinal barrier: a pivotal role in health, inflammation, and cancer“
of Prof. Markus F Neurath, Prof. David Artis, and Prof. Christoph Becker. The review is published in The Lancet Gastroenterology & Hepatology. DOI:10.1016/S2468-1253(24)00390-X

SEPIA offers a centralized database for transcriptomic profiles from diverse IBD mouse models. It enables model comparisons, human IBD data cross-referencing, and hypothesis generation without wet labs or animal stress. Goal: Reduce redundant experiments and support the 3R principles in research.

Vision 2030 – Changing Paradigms in IBD
Join leading researchers on May 26–27, 2025 in Berlin to discuss novel insights into IBD pathogenesis and treatment. Organized by TRR 241.
Info & registration: [email protected]

IBDome is a TRR 241 initiative providing a deeply characterized multi-omics dataset of IBD patients. It links clinical and molecular data to enable advanced cohort analyses, supports hypothesis generation, and a preprint is accessible via the IBDome Explorer. Public release coming soon.

Today's paper presentation is about the paper „TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice“
of our postdoc Lena Erkert. The paper is published in Mucosal Immunology. Feel free to have a look. DOI: 10.1016/j.mucimm.2025.01.003

Today's paper presentation is about the paper „Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease“
of our PhD Li-Li Bao. The paper is published in Science Translational Medicine. Feel free to have a look. DOI: 10.1126/scitranslmed.adn8699 PMID: 39813315

Crohn’s disease and ulcerative colitis are the main types of IBD, with no cure. Rising incidence demands new therapies. TRR241 explores immune-epithelial crosstalk in IBD pathogenesis, uniting experts in Germany and Austria. Our research spans barrier regulation, immune response therapy development.