@vdecrecy.bsky.social
Reposted
☀️ 🌘 RNA Modifications Newsletter -End of summer reading for people who find modified nucleosides relaxing.
Highlights: anticodon-loop crosstalk, MiaA/tryptophan attenuation, ribosomes missing >10 rRNA modifications causing wrong conformations, and growth-dependent remodeling of the tRNA pool.
Highlights: anticodon-loop crosstalk, MiaA/tryptophan attenuation, ribosomes missing >10 rRNA modifications causing wrong conformations, and growth-dependent remodeling of the tRNA pool.
☀️ 🌘 RNA Modifications Newsletter - End of summer 2026 edition
Issue #13
rnamodifupdates.substack.com
September 6, 2026 at 8:03 PM
☀️ 🌘 RNA Modifications Newsletter -End of summer reading for people who find modified nucleosides relaxing.
Highlights: anticodon-loop crosstalk, MiaA/tryptophan attenuation, ribosomes missing >10 rRNA modifications causing wrong conformations, and growth-dependent remodeling of the tRNA pool.
Highlights: anticodon-loop crosstalk, MiaA/tryptophan attenuation, ribosomes missing >10 rRNA modifications causing wrong conformations, and growth-dependent remodeling of the tRNA pool.
Reposted
This is a great resource.
We published an article written by a number of current and former peer review workers in their personal capacities outlining the changes to peer review at the NIH over the last 18 months. It’s a great resource, and we’re grateful to the authors who wrote it! open.substack.com/pub/27unihte...
The Quiet Attack On Science: Subverting NIH Peer Review
Authored by anonymous current and former NIH workers with experience in peer review, this is an overview of all the changes to NIH's peer review over the last 18 months.
open.substack.com
June 8, 2026 at 11:50 AM
This is a great resource.
tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations royalsocietypublishing.org/rsob/article...
tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations
Abstract. tRNA modifications are central to bacterial translational control. Here, we integrated genetics, mass spectrometry, epitranscriptomics and compar
royalsocietypublishing.org
April 17, 2026 at 3:15 PM
tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations royalsocietypublishing.org/rsob/article...
Reposted
Read why NIH colleagues resigned.
Brave writing from Sylvia Chou, Alexa Romberg, Paul Grothaus and Vani Pariyadath. 🧪
#science #standupforscience #integrity
www.statnews.com/2026/01/10/n...
Brave writing from Sylvia Chou, Alexa Romberg, Paul Grothaus and Vani Pariyadath. 🧪
#science #standupforscience #integrity
www.statnews.com/2026/01/10/n...
The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
www.statnews.com
March 13, 2026 at 6:28 PM
Read why NIH colleagues resigned.
Brave writing from Sylvia Chou, Alexa Romberg, Paul Grothaus and Vani Pariyadath. 🧪
#science #standupforscience #integrity
www.statnews.com/2026/01/10/n...
Brave writing from Sylvia Chou, Alexa Romberg, Paul Grothaus and Vani Pariyadath. 🧪
#science #standupforscience #integrity
www.statnews.com/2026/01/10/n...
Reposted
No way will I attend the White House dinner with this President.
I’m standing with @govwesmoore.bsky.social and @colorado.gov — and standing against Trump’s corruption and hatred.
And I’m calling on my Republican colleagues to do the same.
I’m standing with @govwesmoore.bsky.social and @colorado.gov — and standing against Trump’s corruption and hatred.
And I’m calling on my Republican colleagues to do the same.
Democratic governors to boycott White House dinner
More than a half dozen Democrats said Donald Trump disinviting two of their colleagues is the latest example of administration's 'chaos and division.'
www.usatoday.com
February 10, 2026 at 6:07 PM
No way will I attend the White House dinner with this President.
I’m standing with @govwesmoore.bsky.social and @colorado.gov — and standing against Trump’s corruption and hatred.
And I’m calling on my Republican colleagues to do the same.
I’m standing with @govwesmoore.bsky.social and @colorado.gov — and standing against Trump’s corruption and hatred.
And I’m calling on my Republican colleagues to do the same.
Reposted
Reposted
This part of our response essay is where I'm at. Boiling down all of politics to electoralism has been absolutely terrible for resisting rising authoritarianism.
www.bostonreview.net/forum/how-no...
www.bostonreview.net/forum/how-no...
February 3, 2026 at 11:28 PM
This part of our response essay is where I'm at. Boiling down all of politics to electoralism has been absolutely terrible for resisting rising authoritarianism.
www.bostonreview.net/forum/how-no...
www.bostonreview.net/forum/how-no...
Reposted
it's more or less impossible to find issues that poll this badly and he's decided to make it a major, public priority www.cbsnews.com/news/ice-tru...
January 18, 2026 at 2:48 PM
it's more or less impossible to find issues that poll this badly and he's decided to make it a major, public priority www.cbsnews.com/news/ice-tru...
Reposted
Invoke the 25th Amendment.
January 19, 2026 at 4:10 PM
Invoke the 25th Amendment.
Reposted
"Donald Trump now genuinely lives in a different reality, one in which neither grammar nor history nor the normal rules of human interaction now affect him. Also, he really is maniacally, unhealthily obsessive about the Nobel Prize."
www.theatlantic.com/ideas/2026/0...
www.theatlantic.com/ideas/2026/0...
www.theatlantic.com
January 19, 2026 at 3:21 PM
"Donald Trump now genuinely lives in a different reality, one in which neither grammar nor history nor the normal rules of human interaction now affect him. Also, he really is maniacally, unhealthily obsessive about the Nobel Prize."
www.theatlantic.com/ideas/2026/0...
www.theatlantic.com/ideas/2026/0...
Reposted
This afternoon, I was in a meeting with Jay Bhattacharya, and I can confirm this is *exactly* what he both wants and will be doing.
THIS IS NOT HYPERBOLE.
THIS IS NOT HYPERBOLE.
I missed this from a couple of weeks ago, but if you're an NIH-funded investigator, please read.
Peer review will exist to make things look legitimate, but can, and will, be over-ruled. Funding decisions, ultimately, will be done by political appointees.
grants.nih.gov/news-events/...
Peer review will exist to make things look legitimate, but can, and will, be over-ruled. Funding decisions, ultimately, will be done by political appointees.
grants.nih.gov/news-events/...
Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding
grants.nih.gov
December 5, 2025 at 10:07 PM
This afternoon, I was in a meeting with Jay Bhattacharya, and I can confirm this is *exactly* what he both wants and will be doing.
THIS IS NOT HYPERBOLE.
THIS IS NOT HYPERBOLE.
Reposted
Boston's Mayor Wu playing with Yo-Yo Ma at Symphony Hall
November 23, 2025 at 5:11 AM
Boston's Mayor Wu playing with Yo-Yo Ma at Symphony Hall
Reposted
Musk turned on a feature on X that showed country of origin.
He disabled it a couple hours later when it was revealed how many MAGA accounts aren't in the U.S.
Foreign bot disinformation machines exposed.
Seems like Twitter could have done that feature 15 years ago & we wouldn't be here today.
He disabled it a couple hours later when it was revealed how many MAGA accounts aren't in the U.S.
Foreign bot disinformation machines exposed.
Seems like Twitter could have done that feature 15 years ago & we wouldn't be here today.
November 22, 2025 at 11:31 PM
Musk turned on a feature on X that showed country of origin.
He disabled it a couple hours later when it was revealed how many MAGA accounts aren't in the U.S.
Foreign bot disinformation machines exposed.
Seems like Twitter could have done that feature 15 years ago & we wouldn't be here today.
He disabled it a couple hours later when it was revealed how many MAGA accounts aren't in the U.S.
Foreign bot disinformation machines exposed.
Seems like Twitter could have done that feature 15 years ago & we wouldn't be here today.
Reposted
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
November 16, 2025 at 11:43 PM
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
Reposted
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
October 11, 2025 at 3:05 AM
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
Reposted
“With your patient and rigorous work, you can act as a barrier against those who, through the ancient art of lying, seek to create divisions in order to rule by dividing,” he said. “You can also be a bulwark of civility against the quicksand of approximation and post-truth.”
Pope Leo XIV has encouraged international news agencies to stand firm as a bulwark against the "ancient art of lying" and manipulation.
Pope urges news agencies to stand as bulwark against lies, manipulation and post-truths
Pope Leo XIV has encouraged international news agencies to stand firm as a bulwark against the “ancient art of lying” and manipulation.
bit.ly
October 9, 2025 at 2:15 PM
“With your patient and rigorous work, you can act as a barrier against those who, through the ancient art of lying, seek to create divisions in order to rule by dividing,” he said. “You can also be a bulwark of civility against the quicksand of approximation and post-truth.”
Reposted
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation | Open Biology
Transfer RNAs (tRNAs) and their modifications are central to bacterial translation
and physiology, yet their roles in stress adaptation remain underexplored. While extensively
studied in eukaryotes, a...
doi.org
October 8, 2025 at 2:02 PM
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
Reposted
A must read.
It takes years to see a spark transformed to a groundbreaking treatment. It all begins with basic research. Due to sustained #NIH funding, we have better therapeutics, cancer detection, vaccines. We are like 1930s Germany.
🧪 www.infotimes.us/basic-scienc...
via @markhisted.org
It takes years to see a spark transformed to a groundbreaking treatment. It all begins with basic research. Due to sustained #NIH funding, we have better therapeutics, cancer detection, vaccines. We are like 1930s Germany.
🧪 www.infotimes.us/basic-scienc...
via @markhisted.org
Basic Science Is The Foundation Of Future Cures
Injecting partisan politics into American basic science would be terrible for the US: for the economy, and for development of future treatments for diseases like schizophrenia and Alzheimer's.
www.infotimes.us
September 21, 2025 at 4:04 PM
A must read.
It takes years to see a spark transformed to a groundbreaking treatment. It all begins with basic research. Due to sustained #NIH funding, we have better therapeutics, cancer detection, vaccines. We are like 1930s Germany.
🧪 www.infotimes.us/basic-scienc...
via @markhisted.org
It takes years to see a spark transformed to a groundbreaking treatment. It all begins with basic research. Due to sustained #NIH funding, we have better therapeutics, cancer detection, vaccines. We are like 1930s Germany.
🧪 www.infotimes.us/basic-scienc...
via @markhisted.org
Reposted
These are visas for skilled workers — doctors, scientists, and engineers.
This move will hurt US innovation and exacerbate an already serious shortage of medical professionals. In what world does this make sense?? www.bloomberg.com/news/article...
This move will hurt US innovation and exacerbate an already serious shortage of medical professionals. In what world does this make sense?? www.bloomberg.com/news/article...
Trump to Add New $100,000 Fee For H-1B Visas In Latest Crackdown
President Donald Trump is expected to sign a proclamation as soon as Friday that would move to extensively overhaul the H-1B visa program, requiring a $100,000 fee for applications in a bid to curb ov...
www.bloomberg.com
September 19, 2025 at 6:25 PM
These are visas for skilled workers — doctors, scientists, and engineers.
This move will hurt US innovation and exacerbate an already serious shortage of medical professionals. In what world does this make sense?? www.bloomberg.com/news/article...
This move will hurt US innovation and exacerbate an already serious shortage of medical professionals. In what world does this make sense?? www.bloomberg.com/news/article...
Reposted
Yesterday RFK Jr said that he could name no "successes" for US health agencies. He should read this article.
• improved survival or cure for many cancers
• elimination of smallpox, polio, Hib
• reduced child mortality
• effective treatments for HIV, hepatitis C
• increased life expectancy
• improved survival or cure for many cancers
• elimination of smallpox, polio, Hib
• reduced child mortality
• effective treatments for HIV, hepatitis C
• increased life expectancy
American Health Care Gets a Lot Wrong. Here’s What It Gets Right. By Aaron E Carroll | New York Times www.nytimes.com/2025/09/05/o...
Opinion | American Health Care Gets a Lot Wrong. Here’s What It Gets Right.
www.nytimes.com
September 8, 2025 at 3:34 PM
Yesterday RFK Jr said that he could name no "successes" for US health agencies. He should read this article.
• improved survival or cure for many cancers
• elimination of smallpox, polio, Hib
• reduced child mortality
• effective treatments for HIV, hepatitis C
• increased life expectancy
• improved survival or cure for many cancers
• elimination of smallpox, polio, Hib
• reduced child mortality
• effective treatments for HIV, hepatitis C
• increased life expectancy
Reposted
Again let's repeat: "it would take only 4 GOP Senators, or 6 to 7 Representatives, to save the country"
Fine, with filibuster/impeachment hurdles, say 30
Why is everyone in the media laser-focused on What Democrats Must Do? Stop giving those 10-30 Republicans free passes:
bsky.app/profile/mcop...
Fine, with filibuster/impeachment hurdles, say 30
Why is everyone in the media laser-focused on What Democrats Must Do? Stop giving those 10-30 Republicans free passes:
bsky.app/profile/mcop...
Some numbers:
-Most Americans are women.
-Via the Census, about 60 million Americans are in a household that includes a daughter.
-Every American, or human being, should be appalled and disgusted by this.
It would take only 4 GOP Senators, or 6 to 7 Representatives, to save the country.
-Most Americans are women.
-Via the Census, about 60 million Americans are in a household that includes a daughter.
-Every American, or human being, should be appalled and disgusted by this.
It would take only 4 GOP Senators, or 6 to 7 Representatives, to save the country.
Exclusive: Jeffrey Epstein’s estate has given Congress a copy of the 2003 birthday book, including the letter with Trump’s signature that he has said doesn’t exist.
September 8, 2025 at 8:46 PM
Again let's repeat: "it would take only 4 GOP Senators, or 6 to 7 Representatives, to save the country"
Fine, with filibuster/impeachment hurdles, say 30
Why is everyone in the media laser-focused on What Democrats Must Do? Stop giving those 10-30 Republicans free passes:
bsky.app/profile/mcop...
Fine, with filibuster/impeachment hurdles, say 30
Why is everyone in the media laser-focused on What Democrats Must Do? Stop giving those 10-30 Republicans free passes:
bsky.app/profile/mcop...
Reposted
"We’re all in favor of a gold standard for science. But it’s misleading, & even a little insulting, to say that somehow NIH didn’t already support that. Everything that NIH stands for is rigor in sci...There’s some implication here that NIH has been systematically sloppy. I reject that conclusion."🛟
Former NIH chief calls research cuts “careless” and “heartless”
Francis Collins, MD, PhD, lauds lifesaving research supported by the National Institutes of Health, explains why he left, and warns of scientific brain drain.
www.aamc.org
August 22, 2025 at 5:39 AM
"We’re all in favor of a gold standard for science. But it’s misleading, & even a little insulting, to say that somehow NIH didn’t already support that. Everything that NIH stands for is rigor in sci...There’s some implication here that NIH has been systematically sloppy. I reject that conclusion."🛟
Reposted
What they are doing to NIH defies all logic and reason. This admin is needlessly, irreversibly destroying one of the greatest resources our country has ever built. A few quotes from yours' truly are in the video below. Thanks to @nytopinion.nytimes.com for covering
www.nytimes.com/2025/08/24/o...
www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 1:19 PM
What they are doing to NIH defies all logic and reason. This admin is needlessly, irreversibly destroying one of the greatest resources our country has ever built. A few quotes from yours' truly are in the video below. Thanks to @nytopinion.nytimes.com for covering
www.nytimes.com/2025/08/24/o...
www.nytimes.com/2025/08/24/o...
Reposted
Saying goodbye to Elio Schaechter, a titan of the #Microbiology field. Farewell Elio!
August 21, 2025 at 5:29 PM
Saying goodbye to Elio Schaechter, a titan of the #Microbiology field. Farewell Elio!
Reposted
“This and other executive orders eliminating federal funding and forcing faculty to end legally permissible work will deprive students of opportunities for educational advancement and economic flourishing.”
—Todd Wolfson, AAUP President
Read full press release and response to Trump’s directive👇
—Todd Wolfson, AAUP President
Read full press release and response to Trump’s directive👇
AAUP, AFT Leaders Respond to Trump’s Higher Education Admissions Directive
WASHINGTON—American Association of University Professors President Todd Wolfson, AFT President Randi Weingarten, and AFT Secretary-Treasurer Fedrick Ingram and issued the following statements in respo...
www.aaup.org
August 8, 2025 at 7:46 PM
“This and other executive orders eliminating federal funding and forcing faculty to end legally permissible work will deprive students of opportunities for educational advancement and economic flourishing.”
—Todd Wolfson, AAUP President
Read full press release and response to Trump’s directive👇
—Todd Wolfson, AAUP President
Read full press release and response to Trump’s directive👇