Vishwanath Sivalingam
@vishwabio.bsky.social
Protein folding, protein aggregation, phase separation, kinetics and thermodynamics.
Rad23B delays Ataxin-3 liquid-to-solid phase transition through heterotypic buffering
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
July 21, 2025 at 9:18 AM
Rad23B delays Ataxin-3 liquid-to-solid phase transition through heterotypic buffering
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Quantifying protein unfolding kinetics with a high-throughput microfluidic platform
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Quantifying protein unfolding kinetics with a high-throughput microfluidic platform
Even after folding, proteins transiently sample unfolded or partially unfolded intermediates, and these species are often at risk of irreversible alteration ( e.g. via proteolysis, aggregation, or pos...
www.biorxiv.org
March 5, 2025 at 9:49 AM
Quantifying protein unfolding kinetics with a high-throughput microfluidic platform
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vishwanath Sivalingam
If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
pubs.acs.org
January 31, 2025 at 6:30 PM
If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
Reposted by Vishwanath Sivalingam
We wrote a review on the "Physics of droplet regulation in biological cells": arxiv.org/abs/2501.13639 Beside the basic #physics of phase separation, we discuss three aspects that separate cellular from traditional droplets:
January 24, 2025 at 7:55 AM
We wrote a review on the "Physics of droplet regulation in biological cells": arxiv.org/abs/2501.13639 Beside the basic #physics of phase separation, we discuss three aspects that separate cellular from traditional droplets:
Reposted by Vishwanath Sivalingam
Pylustrator got some love on Twitter, and I thought folks here would appreciate it too. 🖌️✨ Here's how it can help make your Matplotlib plots stunning and reproducible: 👇
November 24, 2024 at 3:07 PM
Pylustrator got some love on Twitter, and I thought folks here would appreciate it too. 🖌️✨ Here's how it can help make your Matplotlib plots stunning and reproducible: 👇
Reposted by Vishwanath Sivalingam
November 18, 2024 at 10:22 PM
Tidyplots empowers life scientists with easy code-based data visualization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tidyplots empowers life scientists with easy code-based data visualization
Code-based data visualization is a crucial tool for understanding and communicating experimental findings while ensuring scalability and reproducibility. However, complex programming interfaces pose a...
www.biorxiv.org
November 18, 2024 at 4:52 AM
Tidyplots empowers life scientists with easy code-based data visualization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Discovery and significance of protein-protein interactions in health and disease
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Discovery and significance of protein-protein interactions in health and disease
From identifying individual protein-protein interactions (PPIs) in the 1980s to characterizing
whole-cell interactomes more recently, approaches for identifying cellular PPIs have
opened the way for u...
www.cell.com
November 16, 2024 at 8:04 AM
Discovery and significance of protein-protein interactions in health and disease
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Amyloid is everywhere, but new treatments could stop the toxic build up
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Amyloid is everywhere, but new treatments could stop the toxic build up - Nature Biotechnology
Amyloid deposits are present in the brains of cognitively impaired individuals, but also accumulate throughout the body. Some biotechs aim to keep these misfolded proteins in check to treat a range of...
www.nature.com
November 14, 2024 at 5:48 PM
Amyloid is everywhere, but new treatments could stop the toxic build up
www.nature.com/articles/s41...
www.nature.com/articles/s41...