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yaoxiaofang.bsky.social
yaoxiaofang
@yaoxiaofang.bsky.social
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imetascience.bsky.social
🤔A microbiota-targeted peptide shows promise for protecting the intestine from radiation injury.
Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide.
onlinelibrary.wiley.com/doi/10.1002/...
Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide
AT9(C/G), an oligopeptide derived from human defensin 5, enriches Bifidobacterium pseudolongum and increases lithocholic acid (LCA) levels in the intestine. Reduced levels of LCA link to increased se...
onlinelibrary.wiley.com
March 13, 2026 at 8:54 AM
Reposted by yaoxiaofang
imetascience.bsky.social
🌱 A clickable probe-based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts
onlinelibrary.wiley.com/doi/10.1002/...
Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts
In this study, we develop a flexible Ccc-Chip (protein microarray + bioorthogonal click chemistry) for high-throughput screening of natural covalent active molecules from medicinal plant extracts, id...
onlinelibrary.wiley.com
March 16, 2026 at 10:40 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Climate factors drive the local adaptation of Old World cattle
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
March 17, 2026 at 10:27 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Age-specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population
onlinelibrary.wiley.com/doi/10.1002/...
March 19, 2026 at 11:37 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation
onlinelibrary.wiley.com/doi/10.1002/...
March 20, 2026 at 9:19 AM
Reposted by yaoxiaofang
imetascience.bsky.social
HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota
onlinelibrary.wiley.com/doi/10.1002/...
March 23, 2026 at 10:48 AM
Reposted by yaoxiaofang
imetascience.bsky.social
The microbiome in cancer
onlinelibrary.wiley.com/doi/10.1002/...
March 24, 2026 at 12:25 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations
onlinelibrary.wiley.com/doi/10.1002/...
March 25, 2026 at 10:44 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Specificity landscapes of 40 R2R3-MYBs reveal how paralogs target different cis-elements by homodimeric binding
onlinelibrary.wiley.com/doi/10.1002/...
March 26, 2026 at 11:51 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition
onlinelibrary.wiley.com/doi/10.1002/...
April 1, 2026 at 11:21 AM
Reposted by yaoxiaofang
imetascience.bsky.social
USEARCH 12: Open-source software for sequencing analysis in bioinformatics and microbiome
onlinelibrary.wiley.com/doi/10.1002/...
April 8, 2026 at 9:15 AM
Reposted by yaoxiaofang
imetascience.bsky.social
STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability
onlinelibrary.wiley.com/doi/10.1002/...
April 8, 2026 at 9:19 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform
onlinelibrary.wiley.com/doi/10.1002/...
April 9, 2026 at 11:03 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Two stable gut microbiome guilds predict liver tumor class and treatment responses

⚙️ Functionally opposing microbial guilds highlight an ecological basis for tumor progression and clinical outcomes. #Hepatocellular
onlinelibrary.wiley.com/doi/10.1002/...
Two stable gut microbiome guilds predict liver tumor class and treatment responses
Gut microbiome alterations are linked to hepatocellular carcinoma (HCC), yet taxon-based biomarkers often lack reproducibility. Using shotgun metagenomics from 120 resectable HCC (MT) and 76 benign h...
onlinelibrary.wiley.com
April 10, 2026 at 8:34 AM
Reposted by yaoxiaofang
imetascience.bsky.social
👏A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection
We generated a large-scale single-cell transcriptomic atlas from peripheral blood, profiling more than 612,010 cells from 97 individuals.
#HostResponse
onlinelibrary.wiley.com/doi/10.1002/...
A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection
The study presents a large-scale single-cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings...
onlinelibrary.wiley.com
April 13, 2026 at 11:38 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Spatial multi-omics identifies a NOTCH3-mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

Fibrosis-driven immune exclusion in HCC is linked to endothelial–CAF crosstalk…
onlinelibrary.wiley.com/doi/10.1002/...
Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma
Spatial multi-omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint block....
onlinelibrary.wiley.com
April 14, 2026 at 6:48 AM
Reposted by yaoxiaofang
imetascience.bsky.social
🧐Microbial metabolites in tumor epigenetic regulation
The gut microbiome reshapes tumor epigenetics via metabolite signaling.Bile acids and tryptophan-derived ligands regulate HDAC/DNMT/AhR pathways, altering chromatin states and tumor behavior.
onlinelibrary.wiley.com/doi/10.1002/...
Microbial metabolites in tumor epigenetic regulation
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota-produced SCFAs, secondary BAs, one-carbon metabolites, and tryptopha...
onlinelibrary.wiley.com
April 16, 2026 at 11:16 AM
Reposted by yaoxiaofang
imetascience.bsky.social
💪Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming
⚙️ Enrichment of Lactobacillus johnsonii and secondary bile acids activates PAX7/NMRK2 pathways, promoting muscle regeneration.
onlinelibrary.wiley.com/doi/10.1002/...
Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming
The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid-induced myopathy through the gut–muscle axis. DCS selectively enriches L. johns...
onlinelibrary.wiley.com
April 17, 2026 at 9:20 AM
Reposted by yaoxiaofang
imetascience.bsky.social
💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation
onlinelibrary.wiley.com/doi/10.1002/...
Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation
Microbiota-gut-brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood-brain barrier (BBB), an...
onlinelibrary.wiley.com
December 17, 2025 at 11:55 AM
Reposted by yaoxiaofang
imetascience.bsky.social
⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish
Evidence for liver metabolism of gut-derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mann....
onlinelibrary.wiley.com
December 22, 2025 at 10:43 AM
Reposted by yaoxiaofang
imetascience.bsky.social
Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer
We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The...
onlinelibrary.wiley.com
December 23, 2025 at 12:39 PM
Reposted by yaoxiaofang
imetascience.bsky.social
How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...
December 25, 2025 at 10:55 AM
Reposted by yaoxiaofang
imetascience.bsky.social
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
onlinelibrary.wiley.com/doi/10.1002/...
January 22, 2026 at 12:35 PM
Reposted by yaoxiaofang
imetascience.bsky.social
🗑️ Global landfill systems are major hotspots for antibiotic resistance genes!
⚙️ Metagenomic analyses reveal highly mobile, plasmid-enriched ARGs—dominated by multidrug resistance—and extensive resistome flows within and beyond landfills.
onlinelibrary.wiley.com/doi/10.1002/...
Resistome flow in global landfill systems
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid-driven gene mobility. Waste flows and environmental pathways sustain the transbou...
onlinelibrary.wiley.com
January 15, 2026 at 12:24 PM
Reposted by yaoxiaofang
imetascience.bsky.social
Distinct sinonasal microbiota define clinical subtypes of CRSwNP.
💡 Microbiome-based stratification may support personalized therapy for CRSwNP. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
January 19, 2026 at 1:14 PM