【抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明】
東大などが、抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明した。クライオ電子顕微鏡で2.76Åの分解能。炭素-炭素結合形成ドメインを世界で初めて可視化した。東大など、抗腫瘍性天然物サフラシンB合成酵素SacCの立体構造を解明──クライオ電子顕微鏡で2.76Å、炭素-炭素結合形成ドメインを世界初可視化
stellanews.life/science/13230/
東大などが、抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明した。クライオ電子顕微鏡で2.76Åの分解能。炭素-炭素結合形成ドメインを世界で初めて可視化した。東大など、抗腫瘍性天然物サフラシンB合成酵素SacCの立体構造を解明──クライオ電子顕微鏡で2.76Å、炭素-炭素結合形成ドメインを世界初可視化
stellanews.life/science/13230/
東大など、抗腫瘍性天然物サフラシンB合成酵素SacCの立体構造を解明──クライオ電子顕微鏡で2.76Å、炭素-炭素結合形成ドメインを世界初可視化
東京大学などの研究グループは、抗腫瘍性天然物サフラシンBの複雑な骨格を作る酵素SacCの反応中間状態を、クライオ電子顕微鏡で2.76Åの分解能で解明した。
stellanews.life
November 3, 2026 at 3:50 AM
【抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明】
東大などが、抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明した。クライオ電子顕微鏡で2.76Åの分解能。炭素-炭素結合形成ドメインを世界で初めて可視化した。東大など、抗腫瘍性天然物サフラシンB合成酵素SacCの立体構造を解明──クライオ電子顕微鏡で2.76Å、炭素-炭素結合形成ドメインを世界初可視化
stellanews.life/science/13230/
東大などが、抗腫瘍性天然物サフラシンBの合成酵素SacCの立体構造を解明した。クライオ電子顕微鏡で2.76Åの分解能。炭素-炭素結合形成ドメインを世界で初めて可視化した。東大など、抗腫瘍性天然物サフラシンB合成酵素SacCの立体構造を解明──クライオ電子顕微鏡で2.76Å、炭素-炭素結合形成ドメインを世界初可視化
stellanews.life/science/13230/
District 65’s proposed elimination of School Age Child Care spotlights parent concerns about Right At School
District 65 parents concerned about remaining childcare options after budget cuts proposal - Evanston RoundTable
Evanston/Skokie District 65 administrators unveiled a budget-cutting plan to eliminate the School Age Child Care Program (SACC), drawing criticism from parents over equity and quality concerns regarding...
evanstonroundtable.com
November 2, 2026 at 12:01 PM
District 65’s proposed elimination of School Age Child Care spotlights parent concerns about Right At School
District 65’s proposed elimination of School Age Child Care spotlights parent concerns about Right At School
District 65 parents concerned about remaining childcare options after budget cuts proposal - Evanston RoundTable
Evanston/Skokie District 65 administrators unveiled a budget-cutting plan to eliminate the School Age Child Care Program (SACC), drawing criticism from parents over equity and quality concerns regarding...
evanstonroundtable.com
November 2, 2026 at 5:03 AM
District 65’s proposed elimination of School Age Child Care spotlights parent concerns about Right At School
D65 parents oppose eliminating SACC, board weighs $17 million projection error
D65 parents oppose eliminating SACC, board weighs $17 million projection error
Community members fiercely defended before- and after-school childcare and early childhood education programs during the Evanston/Skokie School District 65 Board of Education’s Monday meeting. That...
dailynorthwestern.com
October 28, 2026 at 12:45 PM
D65 parents oppose eliminating SACC, board weighs $17 million projection error
It’s rotting flesh. Yall are wilding. I know a lot of it might be silicone but still. It’s wrapped in a rotting meat sacc.
Please please stop this madness.
Please please stop this madness.
October 29, 2026 at 2:21 AM
It’s rotting flesh. Yall are wilding. I know a lot of it might be silicone but still. It’s wrapped in a rotting meat sacc.
Please please stop this madness.
Please please stop this madness.
AmiWest 2026 Recap Brings Classic Amiga Hardware and Modern Development Together
#AmiWest2026 #AmiWest #Amiga #CommodoreAmiga #AmigaOS #AmigaOS4 #AROS #AmigaCommunity #RetroComputing #VintageComputing #SACC #VideoToaster #AmigaHardware
theoasisbbs.com/amiwest-2026...
#AmiWest2026 #AmiWest #Amiga #CommodoreAmiga #AmigaOS #AmigaOS4 #AROS #AmigaCommunity #RetroComputing #VintageComputing #SACC #VideoToaster #AmigaHardware
theoasisbbs.com/amiwest-2026...
AmiWest 2026 Recap - The Oasis BBS
AmiWest 2026 recap covers Sacramento's Amiga gathering, from video hardware and developer projects to AI coding and community events.
theoasisbbs.com
October 30, 2026 at 2:12 PM
AmiWest 2026 Recap Brings Classic Amiga Hardware and Modern Development Together
#AmiWest2026 #AmiWest #Amiga #CommodoreAmiga #AmigaOS #AmigaOS4 #AROS #AmigaCommunity #RetroComputing #VintageComputing #SACC #VideoToaster #AmigaHardware
theoasisbbs.com/amiwest-2026...
#AmiWest2026 #AmiWest #Amiga #CommodoreAmiga #AmigaOS #AmigaOS4 #AROS #AmigaCommunity #RetroComputing #VintageComputing #SACC #VideoToaster #AmigaHardware
theoasisbbs.com/amiwest-2026...
How did District 65 become so involved with a for-profit childcare company when it runs its own program? What do parents think of the for-profit program as the school-run one is slated to sunset? “This would be a huge, huge loss,” one parent told me.
evanstonroundtable.com/2026/11/01/d...
evanstonroundtable.com/2026/11/01/d...
District 65 parents concerned about remaining childcare options after budget cuts proposal - Evanston RoundTable
Evanston/Skokie District 65 administrators unveiled a budget-cutting plan to eliminate the School Age Child Care Program (SACC), drawing criticism from parents over equity and quality concerns regardi...
evanstonroundtable.com
November 2, 2026 at 5:35 PM
How did District 65 become so involved with a for-profit childcare company when it runs its own program? What do parents think of the for-profit program as the school-run one is slated to sunset? “This would be a huge, huge loss,” one parent told me.
evanstonroundtable.com/2026/11/01/d...
evanstonroundtable.com/2026/11/01/d...
Parents and educators are rallying against proposed closures in Evanston, fearing devastating impacts on families and students who rely on essential programs like Head Start and school-age childcare.
Get the details!
#IL #CitizenPortal #EvanstonEducation #InclusiveEducation #CommunitySupport
Get the details!
#IL #CitizenPortal #EvanstonEducation #InclusiveEducation #CommunitySupport
Parents, educators plead with Evanston board to save Head Start and school-age childcare
Dozens of parents, teachers and union leaders urged the Evanston CCSD 65 board to halt plans that would close schools and eliminate Head Start and district-run school-age child care (SACC), warning the cuts would harm inclusion and working families.
citizenportal.ai
October 30, 2026 at 1:23 PM
Parents and educators are rallying against proposed closures in Evanston, fearing devastating impacts on families and students who rely on essential programs like Head Start and school-age childcare.
Get the details!
#IL #CitizenPortal #EvanstonEducation #InclusiveEducation #CommunitySupport
Get the details!
#IL #CitizenPortal #EvanstonEducation #InclusiveEducation #CommunitySupport
I actually remember doing something similar last year at SACC! We were in the registration line and someone a few people back had a squeak toy. The first time they squeaked it, I perked up, and the second time I tried turning around quickly. [continued]
October 26, 2026 at 6:06 PM
I actually remember doing something similar last year at SACC! We were in the registration line and someone a few people back had a squeak toy. The first time they squeaked it, I perked up, and the second time I tried turning around quickly. [continued]
Are my comments burlap sacc enough
October 19, 2026 at 3:01 PM
Are my comments burlap sacc enough
（続き）
反応中間体を模倣した共有結合性の分子プローブと、酵素を安定化するパートナータンパク質（MbtH様タンパク質）SacEという2つの要素を鍵とし、SacC–SacE–分子プローブ複合体を形成させることで、単独では凝集し構造解析が困難であった単量体型NRPSの反応状態を高分解能で捉える手法を確立しました。
反応中間体を模倣した共有結合性の分子プローブと、酵素を安定化するパートナータンパク質（MbtH様タンパク質）SacEという2つの要素を鍵とし、SacC–SacE–分子プローブ複合体を形成させることで、単独では凝集し構造解析が困難であった単量体型NRPSの反応状態を高分解能で捉える手法を確立しました。
October 21, 2026 at 10:01 AM
（続き）
反応中間体を模倣した共有結合性の分子プローブと、酵素を安定化するパートナータンパク質（MbtH様タンパク質）SacEという2つの要素を鍵とし、SacC–SacE–分子プローブ複合体を形成させることで、単独では凝集し構造解析が困難であった単量体型NRPSの反応状態を高分解能で捉える手法を確立しました。
反応中間体を模倣した共有結合性の分子プローブと、酵素を安定化するパートナータンパク質（MbtH様タンパク質）SacEという2つの要素を鍵とし、SacC–SacE–分子プローブ複合体を形成させることで、単独では凝集し構造解析が困難であった単量体型NRPSの反応状態を高分解能で捉える手法を確立しました。
🔴 Aumentano i controlli delle forze dell'ordine a Milano, Bari e Como in vista delle manifestazioni di oggi pomeriggio, con perquisizioni e indagati per…
https://fonteufficiale.it/breaking-news/aumentano-i-controlli-delle-forze-dell-ordine-a-milano-bari-e-como-in-vista-dell
https://fonteufficiale.it/breaking-news/aumentano-i-controlli-delle-forze-dell-ordine-a-milano-bari-e-como-in-vista-dell
Aumentano i controlli delle forze dell'ordine a Milano, Bari e Como in vista delle manifestazioni di oggi pomeriggio, con perquisizioni e indagati per istigazione al saccheggio - FonteUfficiale.it: l'informazione mai di parte
Le forze dell’ordine stanno aumentando i controlli in vista delle manifestazioni convocate per oggi pomeriggio alle 15 in una ventina di città italiane, da Milano a Roma, da Bologna a Bari. Le convocazioni sono state rilanciate sui social da sigle spontanee e canali online, dopo gli scontri e i sacc
fonteufficiale.it
October 23, 2026 at 8:18 AM
🔴 Aumentano i controlli delle forze dell'ordine a Milano, Bari e Como in vista delle manifestazioni di oggi pomeriggio, con perquisizioni e indagati per…
https://fonteufficiale.it/breaking-news/aumentano-i-controlli-delle-forze-dell-ordine-a-milano-bari-e-como-in-vista-dell
https://fonteufficiale.it/breaking-news/aumentano-i-controlli-delle-forze-dell-ordine-a-milano-bari-e-como-in-vista-dell
🧬 プレスリリース
抗がん剤につながる天然物を生み出す巨大酵素の反応現場を活写 ―クライオ電子顕微鏡と2つの分子ツールが明かす天然物生合成の妙―
発表のポイント 抗腫瘍性天然物サフラシンBの複雑な5環性骨格を作り出す非典型的な非リボソームペプチド合成酵素（NRPS）SacCの立体構造を、クライオ電子顕微鏡を用いて、2.76 Åの高分解能で解明しました。
https://doi.org/10.1021/jacs.6c09555
#東北大学 #生命科学研究科 #ライフサイエンス #プレスリリース
抗がん剤につながる天然物を生み出す巨大酵素の反応現場を活写 ―クライオ電子顕微鏡と2つの分子ツールが明かす天然物生合成の妙―
発表のポイント 抗腫瘍性天然物サフラシンBの複雑な5環性骨格を作り出す非典型的な非リボソームペプチド合成酵素（NRPS）SacCの立体構造を、クライオ電子顕微鏡を用いて、2.76 Åの高分解能で解明しました。
https://doi.org/10.1021/jacs.6c09555
#東北大学 #生命科学研究科 #ライフサイエンス #プレスリリース
October 21, 2026 at 10:01 AM
🧬 プレスリリース
抗がん剤につながる天然物を生み出す巨大酵素の反応現場を活写 ―クライオ電子顕微鏡と2つの分子ツールが明かす天然物生合成の妙―
発表のポイント 抗腫瘍性天然物サフラシンBの複雑な5環性骨格を作り出す非典型的な非リボソームペプチド合成酵素（NRPS）SacCの立体構造を、クライオ電子顕微鏡を用いて、2.76 Åの高分解能で解明しました。
https://doi.org/10.1021/jacs.6c09555
#東北大学 #生命科学研究科 #ライフサイエンス #プレスリリース
抗がん剤につながる天然物を生み出す巨大酵素の反応現場を活写 ―クライオ電子顕微鏡と2つの分子ツールが明かす天然物生合成の妙―
発表のポイント 抗腫瘍性天然物サフラシンBの複雑な5環性骨格を作り出す非典型的な非リボソームペプチド合成酵素（NRPS）SacCの立体構造を、クライオ電子顕微鏡を用いて、2.76 Åの高分解能で解明しました。
https://doi.org/10.1021/jacs.6c09555
#東北大学 #生命科学研究科 #ライフサイエンス #プレスリリース
Letter: SACC program is a lifeline, not a luxury
evanstonroundtable.com
October 19, 2026 at 7:05 PM
Letter: SACC program is a lifeline, not a luxury
A portable AC listed as "8,000 BTU" and one listed as "4,000 BTU SACC" can be the same actual cooling power. SACC is the newer, more honest US standard -- the bigger number on the box is usually the outdated one: pickloot.com/blog/best-portable-air-conditioners-2026/
October 19, 2026 at 1:15 PM
A portable AC listed as "8,000 BTU" and one listed as "4,000 BTU SACC" can be the same actual cooling power. SACC is the newer, more honest US standard -- the bigger number on the box is usually the outdated one: pickloot.com/blog/best-portable-air-conditioners-2026/
SacC, an enzyme that builds a five-ring scaffold shared with a cancer drug, has been visualized in near-atomic detail. The model captures an early step; later ring closures remain unseen.
Frozen in action: Visualizing how a cancer drug scaffold is built
A joint research group led by Ryo Tanifuji and Hiroki Oguri from the University of Tokyo and Yoshikazu Tanaka from Tohoku University has visualized SacC, an enzyme that plays a key role in building the complex five-ring core of safracin B.
phys.org
October 19, 2026 at 3:00 PM
SacC, an enzyme that builds a five-ring scaffold shared with a cancer drug, has been visualized in near-atomic detail. The model captures an early step; later ring closures remain unseen.
this was a goal at one point, hooking up my ships with the sacc flight plugin, and its not off the table! but i have something else in mind. soon tm.
October 18, 2026 at 11:11 AM
this was a goal at one point, hooking up my ships with the sacc flight plugin, and its not off the table! but i have something else in mind. soon tm.