Żesławska et al.: Crystallographic studies of piperazine derivatives of 5,5-dimethylhydantoin in the search for structural features of α1-adrenoreceptors antagonists ##Dimethylhydantoin##HydrogenBonding... ##IUCrhttps://journals.iucr.org/paper?S2053229625002608
Crystallographic studies of piperazine derivatives of 5,5-dimethylhydantoin in the search for structural features of α1-adrenoreceptors antagonists
Six 5,5-dimethylhydantoin derivatives were investigated towards the search for structural features responsible for affinity for α1-adrenoreceptors. Compounds with higher activity prefer an extended conformation, which leads to larger distances between the end aromatic rings, while for compounds with lower affinity, the distances between the end aromatic rings are shorter.
journals.iucr.org
April 9, 2025 at 12:00 AM
Żesławska et al.: Crystallographic studies of piperazine derivatives of 5,5-dimethylhydantoin in the search for structural features of α1-adrenoreceptors antagonists ##Dimethylhydantoin##HydrogenBonding... ##IUCrhttps://journals.iucr.org/paper?S2053229625002608