Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans 🧪
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.
www.cell.com
December 5, 2024 at 5:44 AM
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans 🧪
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
It is amazing that @dudinlab.bsky.social beautiful #ExM composition has been selected to highlight our #6mA work for the cover of @natgenet.nature.com. #Protists (and ichthyosporeans in particular) in the cover of NG must be quite unique!
December 11, 2025 at 11:59 AM
It is amazing that @dudinlab.bsky.social beautiful #ExM composition has been selected to highlight our #6mA work for the cover of @natgenet.nature.com. #Protists (and ichthyosporeans in particular) in the cover of NG must be quite unique!
Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.
October 8, 2025 at 12:17 PM
Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.
🤭Kto by pomyślał, że jeden człowiek, obciążony 6ma bankructwami w tak szybki sposób zakończy karierę USA jako supermocarstwa🤣
March 7, 2025 at 5:49 AM
🤭Kto by pomyślał, że jeden człowiek, obciążony 6ma bankructwami w tak szybki sposób zakończy karierę USA jako supermocarstwa🤣
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.
www.cell.com
December 8, 2024 at 8:25 PM
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Breaking paradigms: Finding 6mA DNA methylation in eukaryotes
Francisco Falcon @ffalcon.bsky.social highlights research from @alexdemendoza.bsky.social and team on 6mA in eukaryotes.
#preprint #preLights
👀⤵️
prelights.biologists.com/highlights/a...
Francisco Falcon @ffalcon.bsky.social highlights research from @alexdemendoza.bsky.social and team on 6mA in eukaryotes.
#preprint #preLights
👀⤵️
prelights.biologists.com/highlights/a...
Adenine DNA methylation associated to transcription is widespread across eukaryotes - preLights
Breaking paradigms: Finding 6mA DNA methylation in eukaryotes.
prelights.biologists.com
January 15, 2025 at 10:00 AM
Breaking paradigms: Finding 6mA DNA methylation in eukaryotes
Francisco Falcon @ffalcon.bsky.social highlights research from @alexdemendoza.bsky.social and team on 6mA in eukaryotes.
#preprint #preLights
👀⤵️
prelights.biologists.com/highlights/a...
Francisco Falcon @ffalcon.bsky.social highlights research from @alexdemendoza.bsky.social and team on 6mA in eukaryotes.
#preprint #preLights
👀⤵️
prelights.biologists.com/highlights/a...
Very proud of my 2nd PhD student, Pedro Romero Charria, who defended his viva yesterday. Big thanks to @michael-imbeault.bsky.social and Roman Arguello for the discussion. Pedro's main work on #6mA in protists was published late last year (www.nature.com/articles/s41...), but there's more to come!
April 17, 2026 at 11:01 AM
Very proud of my 2nd PhD student, Pedro Romero Charria, who defended his viva yesterday. Big thanks to @michael-imbeault.bsky.social and Roman Arguello for the discussion. Pedro's main work on #6mA in protists was published late last year (www.nature.com/articles/s41...), but there's more to come!
🌕 | contagem reiniciada!
ARMYs, iniciamos mais um dia de contagem e essa é a nossa sugestão de playlist do dia
↪️ open.spotify.com/playlist/6Ma...
ARMYs, iniciamos mais um dia de contagem e essa é a nossa sugestão de playlist do dia
↪️ open.spotify.com/playlist/6Ma...
Maknae focus
Playlist · Scenery Brasil · 242 items · 29 likes
open.spotify.com
September 3, 2024 at 12:42 AM
🌕 | contagem reiniciada!
ARMYs, iniciamos mais um dia de contagem e essa é a nossa sugestão de playlist do dia
↪️ open.spotify.com/playlist/6Ma...
ARMYs, iniciamos mais um dia de contagem e essa é a nossa sugestão de playlist do dia
↪️ open.spotify.com/playlist/6Ma...
Sequence-independent 6mA methyltransferases for epigenetic profiling and editing. #DNAmodification #6mA #Epigenetics #Genomics @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
October 24, 2025 at 1:49 PM
Sequence-independent 6mA methyltransferases for epigenetic profiling and editing. #DNAmodification #6mA #Epigenetics #Genomics @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Good morning fluffers!! How are we all doing today? I think it is still safe to say, Not my monkey's, not my circus, but I definitely am familiar with the clowns. Daily reminder, don't be an asshole, be the reason someone smiles.
Playlist - its an Aussie rock day.
open.spotify.com/playlist/6Ma...
Playlist - its an Aussie rock day.
open.spotify.com/playlist/6Ma...
April 1, 2025 at 4:30 PM
Good morning fluffers!! How are we all doing today? I think it is still safe to say, Not my monkey's, not my circus, but I definitely am familiar with the clowns. Daily reminder, don't be an asshole, be the reason someone smiles.
Playlist - its an Aussie rock day.
open.spotify.com/playlist/6Ma...
Playlist - its an Aussie rock day.
open.spotify.com/playlist/6Ma...
A breezy day at Leavitt Falls overlooking the ~6ma Little Walker Caldera and the lovely meanders of the West Walker River. Already breezy and dry. I don’t think I want to spend the night on Friday in 50pm wind gusts at 11,000’. Hopefully friends will agree.
June 23, 2026 at 9:05 PM
A breezy day at Leavitt Falls overlooking the ~6ma Little Walker Caldera and the lovely meanders of the West Walker River. Already breezy and dry. I don’t think I want to spend the night on Friday in 50pm wind gusts at 11,000’. Hopefully friends will agree.
Wheatstone bridge Wednesday w/ the ct160
A very strong GE 6au6 pulling 13mA and 6mA/v
A very strong GE 6au6 pulling 13mA and 6mA/v
July 22, 2026 at 4:40 PM
Wheatstone bridge Wednesday w/ the ct160
A very strong GE 6au6 pulling 13mA and 6mA/v
A very strong GE 6au6 pulling 13mA and 6mA/v
Check out this cool story from @alexdemendoza.bsky.social lab about the deep evolutionary origins of transcription-linked 6mA in eukaryotes. Glad to have been involved in it.
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 19, 2025 at 2:47 PM
Check out this cool story from @alexdemendoza.bsky.social lab about the deep evolutionary origins of transcription-linked 6mA in eukaryotes. Glad to have been involved in it.
Morning fluffers!! Sorry its been a couple of busy days. Everyone still horrified ? Good status quo nothing has changed apart from the daily stupid shit being flung at us all.
Playlist - Its an Aussie day
open.spotify.com/playlist/6Ma...
Playlist - Its an Aussie day
open.spotify.com/playlist/6Ma...
April 30, 2025 at 4:33 PM
Morning fluffers!! Sorry its been a couple of busy days. Everyone still horrified ? Good status quo nothing has changed apart from the daily stupid shit being flung at us all.
Playlist - Its an Aussie day
open.spotify.com/playlist/6Ma...
Playlist - Its an Aussie day
open.spotify.com/playlist/6Ma...
" @pacbio.bsky.social SMRT consistently demonstrated superior performance compared to other tools. These rigorous comparative studies established SMRT as the most reliable tool for #bacterial 6mA detection currently." #PacBio #HiFi #longread #microbial #methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comprehensive comparison of the third-generation sequencing tools for bacterial 6mA profiling - Nature Communications
Bacterial N6-methyladenine (6mA) is an intrinsic epigenetic marker. Here, the authors evaluate and compare eight third-generation sequencing tools for 6mA identification, assessing performance in term...
www.nature.com
May 12, 2025 at 7:05 PM
" @pacbio.bsky.social SMRT consistently demonstrated superior performance compared to other tools. These rigorous comparative studies established SMRT as the most reliable tool for #bacterial 6mA detection currently." #PacBio #HiFi #longread #microbial #methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#vascularCalcification
DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification
ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet
@jci.org 2021
www.jci.org/articles/vie...
DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification
ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet
@jci.org 2021
www.jci.org/articles/vie...
October 12, 2025 at 6:58 PM
#vascularCalcification
DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification
ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet
@jci.org 2021
www.jci.org/articles/vie...
DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification
ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet
@jci.org 2021
www.jci.org/articles/vie...
Good Morning Bluesky!
I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬
Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too!
journals.asm.org/doi/10.1128/...
I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬
Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too!
journals.asm.org/doi/10.1128/...
Differential adenine methylation analysis reveals increased variability in 6mA in the absence of met...
Methylation greatly influences the bacterial genome by guiding DNA repair and regulating
pathogenic and stress-response phenotypes. But, the rate of epigenetic changes and
their consequences on molecu...
journals.asm.org
October 5, 2023 at 1:28 PM
Good Morning Bluesky!
I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬
Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too!
journals.asm.org/doi/10.1128/...
I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬
Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too!
journals.asm.org/doi/10.1128/...
RNA methylation in retrotransposon control. #RNAmethylation #6mA #LTR #L1#ERV #RetrotransposonControl #RNAdecay #RNAstability #GenomeRegulation #CellularDifferentiation @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
www.cell.com
June 7, 2025 at 10:49 AM
RNA methylation in retrotransposon control. #RNAmethylation #6mA #LTR #L1#ERV #RetrotransposonControl #RNAdecay #RNAstability #GenomeRegulation #CellularDifferentiation @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
New Article: "Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance" rdcu.be/eBbLK
MORCs stabilize PRC2 preferentially at bivalent domains to maintain high levels of H3 K27 trimethylation...
MORCs stabilize PRC2 preferentially at bivalent domains to maintain high levels of H3 K27 trimethylation...
August 18, 2025 at 10:43 AM
New Article: "Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance" rdcu.be/eBbLK
MORCs stabilize PRC2 preferentially at bivalent domains to maintain high levels of H3 K27 trimethylation...
MORCs stabilize PRC2 preferentially at bivalent domains to maintain high levels of H3 K27 trimethylation...
🎄 New Dorado release (v0.9.0) – and it's big!
🚀 Dorado polish command (experimental) for improving draft assemblies – faster & more accurate than Medaka
⚡ Faster modified base calling models
🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA calling
github.com/nanoporetech...
🚀 Dorado polish command (experimental) for improving draft assemblies – faster & more accurate than Medaka
⚡ Faster modified base calling models
🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA calling
github.com/nanoporetech...
Release v0.9.0 · nanoporetech/dorado
[0.9.0] (16 Dec 2024)
This major release of Dorado introduces several new features and enhancements. The polish command, currently experimental, is optimised for refining draft assemblies of human ...
github.com
December 17, 2024 at 11:59 AM
🎄 New Dorado release (v0.9.0) – and it's big!
🚀 Dorado polish command (experimental) for improving draft assemblies – faster & more accurate than Medaka
⚡ Faster modified base calling models
🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA calling
github.com/nanoporetech...
🚀 Dorado polish command (experimental) for improving draft assemblies – faster & more accurate than Medaka
⚡ Faster modified base calling models
🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA calling
github.com/nanoporetech...
Therefore, the Last Eukaryotic Common Ancestor had a dual methylation system: 6mA for transcriptionally permissive chromatin and 5mC for silencing. This dual pattern is maintained in some extant eukaryotes but has diverged in many others, including ALL multicellular groups that lost AMT1. 8/9
November 18, 2025 at 12:00 PM
Therefore, the Last Eukaryotic Common Ancestor had a dual methylation system: 6mA for transcriptionally permissive chromatin and 5mC for silencing. This dual pattern is maintained in some extant eukaryotes but has diverged in many others, including ALL multicellular groups that lost AMT1. 8/9
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
December 3, 2024 at 6:06 PM
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Want epigenetic information automatically included in your sequencing runs?
HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.
See how: bit.ly/3YSPBdo
#PacBio #HiFisequencing
HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.
See how: bit.ly/3YSPBdo
#PacBio #HiFisequencing
March 2, 2026 at 8:43 PM
Want epigenetic information automatically included in your sequencing runs?
HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.
See how: bit.ly/3YSPBdo
#PacBio #HiFisequencing
HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.
See how: bit.ly/3YSPBdo
#PacBio #HiFisequencing
ASCII Super Stick L5 (1992)
January 5, 2026 at 1:41 AM
ASCII Super Stick L5 (1992)