Circulating tumor cells first identified over 100 years ago. Thankfully, science in this area moving a lot faster now
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:01 AM
Circulating tumor cells first identified over 100 years ago. Thankfully, science in this area moving a lot faster now
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
One relatively rare subtype of TNBC - luminal like with androgen receptor - is sensitive to the CDK 4/6 inhibitors in PRECLINICAL models#AACR18
November 19, 2024 at 3:22 AM
One relatively rare subtype of TNBC - luminal like with androgen receptor - is sensitive to the CDK 4/6 inhibitors in PRECLINICAL models#AACR18
Early work suggests that if after a few days of treatment with a CDK4/6 inhibitor there is no impact on the phosphorylation of Rb, then drug is unlikely to be effective #AACR18
November 19, 2024 at 3:22 AM
Early work suggests that if after a few days of treatment with a CDK4/6 inhibitor there is no impact on the phosphorylation of Rb, then drug is unlikely to be effective #AACR18
At #AACRSSP18 with Dr Carolyn Compton giving a cancer "mini med school". #AACR18
November 19, 2024 at 3:22 AM
At #AACRSSP18 with Dr Carolyn Compton giving a cancer "mini med school". #AACR18
Here's cancer mini med school for you, without having to come to cold, rainy Chicago #AACRSSP18 #AACR18
November 19, 2024 at 3:22 AM
Here's cancer mini med school for you, without having to come to cold, rainy Chicago #AACRSSP18 #AACR18
#AACRSSP18 #AACR18
"Indel" is an insertion or a deletion in a gene if you every hear that term. We need mutations, but in key systems they need to be repaired or we can end up with cancer
"Indel" is an insertion or a deletion in a gene if you every hear that term. We need mutations, but in key systems they need to be repaired or we can end up with cancer
November 19, 2024 at 3:22 AM
#AACRSSP18 #AACR18
"Indel" is an insertion or a deletion in a gene if you every hear that term. We need mutations, but in key systems they need to be repaired or we can end up with cancer
"Indel" is an insertion or a deletion in a gene if you every hear that term. We need mutations, but in key systems they need to be repaired or we can end up with cancer
Tumor suppressor genes are key in fixing mutations, but if the tumor suppressors are mutated we're screwed. At the time a tumor is detectable, there may be 10 MILLION clonal variants which is why it's so hard to treat with a single agent
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:22 AM
Tumor suppressor genes are key in fixing mutations, but if the tumor suppressors are mutated we're screwed. At the time a tumor is detectable, there may be 10 MILLION clonal variants which is why it's so hard to treat with a single agent
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:22 AM
November 19, 2024 at 3:22 AM
November 19, 2024 at 3:22 AM
Oncogenes are dominant mutationsnthat pushes cell to divide (gain of function mutation). Mutation in suppressor genes (loss of function) means there are no brakes on the system. Both cause cancer.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:22 AM
Oncogenes are dominant mutationsnthat pushes cell to divide (gain of function mutation). Mutation in suppressor genes (loss of function) means there are no brakes on the system. Both cause cancer.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
With time, more heterogeneity (more clonal subtypes), so harder to treat or eliminate
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:02 AM
With time, more heterogeneity (more clonal subtypes), so harder to treat or eliminate
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
Normal cells need to be attached to the basement membrane and other cells, but cancer cells don't: this is epithelial to mesenchymal transformation (EMT) and key to invasion.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:02 AM
Normal cells need to be attached to the basement membrane and other cells, but cancer cells don't: this is epithelial to mesenchymal transformation (EMT) and key to invasion.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
Metastatic cells are like Olympic decathaletes in all the things they need to do to spread. Why can't my cells be couch potatoes?
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:02 AM
Metastatic cells are like Olympic decathaletes in all the things they need to do to spread. Why can't my cells be couch potatoes?
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 3:02 AM
November 19, 2024 at 3:02 AM