Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialogangliosi
www.science.org/doi/10.1126/...
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialogangliosi
www.science.org/doi/10.1126/...
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
www.science.org
December 12, 2024 at 7:14 PM
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialogangliosi
www.science.org/doi/10.1126/...
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialogangliosi
www.science.org/doi/10.1126/...
Nature research paper: ACLY inhibition promotes tumour immunity and suppresses liver cancer
go.nature.com/4l7n4t8
go.nature.com/4l7n4t8
ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature
Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.
go.nature.com
August 4, 2025 at 10:31 AM
Nature research paper: ACLY inhibition promotes tumour immunity and suppresses liver cancer
go.nature.com/4l7n4t8
go.nature.com/4l7n4t8
Yeah… sounds very much ACLy to me now
August 20, 2025 at 7:48 PM
Yeah… sounds very much ACLy to me now
Here is link to Shixin's new paper: www.science.org/doi/epdf/10....
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
www.science.org
December 14, 2024 at 3:53 PM
Here is link to Shixin's new paper: www.science.org/doi/epdf/10....
Happy to share our latest findings @bloodneoplasia.bsky.social uncovering an ACLY-MYC feedforward loop in T-ALL, led by @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
Redirecting
doi.org
January 21, 2025 at 2:04 PM
Happy to share our latest findings @bloodneoplasia.bsky.social uncovering an ACLY-MYC feedforward loop in T-ALL, led by @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
Simon & Simon Theme (Intro & Outro)
YouTube video by 11db11
m.youtube.com
July 20, 2025 at 3:04 PM
Uploaded it in video form (I think I can call it a visualizer???)
www.youtube.com/watch?v=aCly...
www.youtube.com/watch?v=aCly...
December 24, 2025 at 11:55 PM
Uploaded it in video form (I think I can call it a visualizer???)
www.youtube.com/watch?v=aCly...
www.youtube.com/watch?v=aCly...
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
January 30, 2025 at 9:16 AM
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
www.science.org
December 12, 2024 at 10:36 PM
The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
T cells get hungry! Check out Shixin Ma's new paper showing nutrient switching controls T cell exhaustion. Nutrients metabolized in the nucleus by ACSS2 and ACLY direct histone acetylation at key loci via binding to specific HATs, indicating a metabolic code guides our histone code. @science.org
December 14, 2024 at 3:52 PM
T cells get hungry! Check out Shixin Ma's new paper showing nutrient switching controls T cell exhaustion. Nutrients metabolized in the nucleus by ACSS2 and ACLY direct histone acetylation at key loci via binding to specific HATs, indicating a metabolic code guides our histone code. @science.org
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation
doi.org/10.1101/2025...
@macattacklab.bsky.social
doi.org/10.1101/2025...
@macattacklab.bsky.social
March 17, 2025 at 9:22 PM
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation
doi.org/10.1101/2025...
@macattacklab.bsky.social
doi.org/10.1101/2025...
@macattacklab.bsky.social
Bonjour et bon lundi ! Si vous utilisez l'excellent logiciel de dessin libre et open-source Krita et que vous vous intéressez à l'IA générative, regardez du côté de krita-ai-diffusion qui permet de générer des images directement depuis le logiciel ⬇️
github.com/Acly/krita-a...
github.com/Acly/krita-a...
GitHub - Acly/krita-ai-diffusion: Streamlined interface for generating images with AI in Krita. Inpa...
Streamlined interface for generating images with AI in Krita. Inpaint and outpaint with optional text prompt, no tweaking required. - GitHub - Acly/krita-ai-diffusion: Streamlined interface for gen...
github.com
November 27, 2023 at 7:21 AM
Bonjour et bon lundi ! Si vous utilisez l'excellent logiciel de dessin libre et open-source Krita et que vous vous intéressez à l'IA générative, regardez du côté de krita-ai-diffusion qui permet de générer des images directement depuis le logiciel ⬇️
github.com/Acly/krita-a...
github.com/Acly/krita-a...
drum roll - Bluesky's first starter list for #sociophonetics
Abby Walker bsky.app/profile/abby...
Adrian Leemann bsky.app/profile/adri...
Alan Yu bsky.app/profile/acly...
Betsy Sneller bsky.app/profile/bets...
Christian Ilbury bsky.app/profile/chri...
Christopher Carignan bsky.app/profile/cari...
Abby Walker bsky.app/profile/abby...
Adrian Leemann bsky.app/profile/adri...
Alan Yu bsky.app/profile/acly...
Betsy Sneller bsky.app/profile/bets...
Christian Ilbury bsky.app/profile/chri...
Christopher Carignan bsky.app/profile/cari...
bsky.app
November 18, 2024 at 4:41 PM
drum roll - Bluesky's first starter list for #sociophonetics
Abby Walker bsky.app/profile/abby...
Adrian Leemann bsky.app/profile/adri...
Alan Yu bsky.app/profile/acly...
Betsy Sneller bsky.app/profile/bets...
Christian Ilbury bsky.app/profile/chri...
Christopher Carignan bsky.app/profile/cari...
Abby Walker bsky.app/profile/abby...
Adrian Leemann bsky.app/profile/adri...
Alan Yu bsky.app/profile/acly...
Betsy Sneller bsky.app/profile/bets...
Christian Ilbury bsky.app/profile/chri...
Christopher Carignan bsky.app/profile/cari...
Overall, our findings unveil a MYC-ACLY loop in which ACLY promotes MYC expression by providing the acetyl-CoA units needed for its epigenetic regulation, while MYC itself binds to the ACLY promoter and transcriptionally activates it, resulting in a feedforward loop supports T-ALL growth
January 21, 2025 at 2:18 PM
Overall, our findings unveil a MYC-ACLY loop in which ACLY promotes MYC expression by providing the acetyl-CoA units needed for its epigenetic regulation, while MYC itself binds to the ACLY promoter and transcriptionally activates it, resulting in a feedforward loop supports T-ALL growth
Happy to see our latest @bloodneoplasia.bsky.social paper finally on PubMed!! @dasilva-diz.bsky.social @rutgerscancer.bsky.social
pubmed.ncbi.nlm.nih.gov/40453140/
pubmed.ncbi.nlm.nih.gov/40453140/
A feedforward loop between ACLY and MYC supports T-ALL progression in vivo - PubMed
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy in need of novel therapeutic approaches. Here, we identify ATP-citrate lyase (ACLY) as overexpressed in human T-ALL and as a p...
pubmed.ncbi.nlm.nih.gov
June 2, 2025 at 1:36 PM
Happy to see our latest @bloodneoplasia.bsky.social paper finally on PubMed!! @dasilva-diz.bsky.social @rutgerscancer.bsky.social
pubmed.ncbi.nlm.nih.gov/40453140/
pubmed.ncbi.nlm.nih.gov/40453140/
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation www.nature.com/articles/s41...
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation - Nature Neuroscience
The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-Co...
www.nature.com
May 1, 2026 at 2:09 AM
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation www.nature.com/articles/s41...
Barry Adams: The Issues With LLM Answers - IMHO
YouTube video by Shelley Walsh
www.youtube.com
June 12, 2025 at 10:06 AM
🥗 What you eat shapes your immunity 🦠
A new @science.org study shows that what you eat can change how immune cells work, affecting their ability to fight infections and cancer.
🔗 doi.org/10.1126/scie...
#SciComm #Immunology #Nutrition 🧪
A new @science.org study shows that what you eat can change how immune cells work, affecting their ability to fight infections and cancer.
🔗 doi.org/10.1126/scie...
#SciComm #Immunology #Nutrition 🧪
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
doi.org
December 14, 2024 at 3:49 PM
🥗 What you eat shapes your immunity 🦠
A new @science.org study shows that what you eat can change how immune cells work, affecting their ability to fight infections and cancer.
🔗 doi.org/10.1126/scie...
#SciComm #Immunology #Nutrition 🧪
A new @science.org study shows that what you eat can change how immune cells work, affecting their ability to fight infections and cancer.
🔗 doi.org/10.1126/scie...
#SciComm #Immunology #Nutrition 🧪
youtube.com
January 31, 2025 at 6:53 PM
Some eye candy from the Finnish Defence Forces. www.youtube.com/watch?v=AcLY...
Combat Camera Showreel 2024 – Finnish Defence Forces
YouTube video by Puolustusvoimat - Försvarsmakten - The Finnish Defence Forces
www.youtube.com
January 31, 2025 at 6:21 PM
Some eye candy from the Finnish Defence Forces. www.youtube.com/watch?v=AcLY...
Washington University scientists found that NK cells need the enzyme ACLY to fight infections and tumors.
Without it, they lose energy and attack power.
Adding acetate restores their function, showing how metabolism shapes immunity.
www.biorxiv.org/content/10.1...
Without it, they lose energy and attack power.
Adding acetate restores their function, showing how metabolism shapes immunity.
www.biorxiv.org/content/10.1...
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation
Natural Killer (NK) cells are innate immune lymphocytes important for host viral and tumor immunity. We investigated the requirement for ATP citrate lyase (ACLY) in NK cell function using an inducible...
www.biorxiv.org
March 10, 2025 at 5:43 PM
Washington University scientists found that NK cells need the enzyme ACLY to fight infections and tumors.
Without it, they lose energy and attack power.
Adding acetate restores their function, showing how metabolism shapes immunity.
www.biorxiv.org/content/10.1...
Without it, they lose energy and attack power.
Adding acetate restores their function, showing how metabolism shapes immunity.
www.biorxiv.org/content/10.1...
A new AI review! Acly/krita-ai-diffusion ⭐3.9/5.0
`krita-ai-diffusion` is a mature, actively maintained Krita plugin that brings modern diffusion workflows (inpainting, live painting, regions, ControlNet/IP-Adapter, upscaling, model/preset management) ...
https://gitrated.com/Acly/krita-ai-diffusion
`krita-ai-diffusion` is a mature, actively maintained Krita plugin that brings modern diffusion workflows (inpainting, live painting, regions, ControlNet/IP-Adapter, upscaling, model/preset management) ...
https://gitrated.com/Acly/krita-ai-diffusion
March 29, 2026 at 1:29 AM
A new AI review! Acly/krita-ai-diffusion ⭐3.9/5.0
`krita-ai-diffusion` is a mature, actively maintained Krita plugin that brings modern diffusion workflows (inpainting, live painting, regions, ControlNet/IP-Adapter, upscaling, model/preset management) ...
https://gitrated.com/Acly/krita-ai-diffusion
`krita-ai-diffusion` is a mature, actively maintained Krita plugin that brings modern diffusion workflows (inpainting, live painting, regions, ControlNet/IP-Adapter, upscaling, model/preset management) ...
https://gitrated.com/Acly/krita-ai-diffusion