Beijing Institute of Technology researchers synthesized CRISPR engineering into a DBTL framework, showing how structural tuning, DMS, and generative AI (OpenCRISPR-1) are overcoming PAM and size bottlenecks. 🧬🤖 #CRISPR #GeneEditing #ACSSynBio2026 #GenerativeAI #SyntheticBiology #AgBiotech