Why not screen out people with the genetic variants of ACTN3 which improve muscle speed? Or any of hundreds of other small mutations that benefit athletic activity?
Why take baby steps? Just go full Harrison Bergeron, already!
Why take baby steps? Just go full Harrison Bergeron, already!
August 3, 2026 at 3:02 PM
Why not screen out people with the genetic variants of ACTN3 which improve muscle speed? Or any of hundreds of other small mutations that benefit athletic activity?
Why take baby steps? Just go full Harrison Bergeron, already!
Why take baby steps? Just go full Harrison Bergeron, already!
ACTN3, for athletes, perhaps?
November 27, 2024 at 5:20 PM
ACTN3, for athletes, perhaps?
don't want surgery just want to have a violent viral conversation with our rs1815739 SNP from ACTN3 where we can convince it to change it's ways
November 30, 2024 at 4:56 PM
don't want surgery just want to have a violent viral conversation with our rs1815739 SNP from ACTN3 where we can convince it to change it's ways
This 🐂 💩 enrages me.
If people were worried about “advantages”, where’s the outrage over Eero Mantyranta? Or the variations in ACTN3 or ACE genes? Or heritability?
I’m so, so exhausted by the ignorance of people who pretend to be progressive while acting as the propaganda arm for right wingers.
If people were worried about “advantages”, where’s the outrage over Eero Mantyranta? Or the variations in ACTN3 or ACE genes? Or heritability?
I’m so, so exhausted by the ignorance of people who pretend to be progressive while acting as the propaganda arm for right wingers.
You really need to take a step back and think about this. The LGBTQ community deserves every right to love who they want to love and not be discriminated against. But insisting on allowing trans males to compete in girls sports where they have physical advantages? This is how we lose elections.
June 3, 2025 at 6:13 PM
This 🐂 💩 enrages me.
If people were worried about “advantages”, where’s the outrage over Eero Mantyranta? Or the variations in ACTN3 or ACE genes? Or heritability?
I’m so, so exhausted by the ignorance of people who pretend to be progressive while acting as the propaganda arm for right wingers.
If people were worried about “advantages”, where’s the outrage over Eero Mantyranta? Or the variations in ACTN3 or ACE genes? Or heritability?
I’m so, so exhausted by the ignorance of people who pretend to be progressive while acting as the propaganda arm for right wingers.
ACTN3 genotype influences androgen response in developing murine skeletal muscle
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ACTN3 genotype influences androgen response in developing murine skeletal muscle
ACTN3 deficiency (which is common in humans) reduces muscle androgen receptor levels and modifies muscle response to testosterone.
www.science.org
August 30, 2025 at 7:10 PM
ACTN3 genotype influences androgen response in developing murine skeletal muscle
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Name: Daiyu: Cut-throat Empress
Age: 72
Height: 5'9
Country: Unknown (Presumably China)
Fighting Style: Silent Claw (静爪 Jìng Zhǎo)
Genetic Mutation's: Rapid Nail Growth and Actn3 (Fast Muscle Fibers)
#TheArtsofMars #martialarts #assassin #oc #ocart #originalcharacter #Gilf
Age: 72
Height: 5'9
Country: Unknown (Presumably China)
Fighting Style: Silent Claw (静爪 Jìng Zhǎo)
Genetic Mutation's: Rapid Nail Growth and Actn3 (Fast Muscle Fibers)
#TheArtsofMars #martialarts #assassin #oc #ocart #originalcharacter #Gilf
January 15, 2025 at 7:31 AM
Name: Daiyu: Cut-throat Empress
Age: 72
Height: 5'9
Country: Unknown (Presumably China)
Fighting Style: Silent Claw (静爪 Jìng Zhǎo)
Genetic Mutation's: Rapid Nail Growth and Actn3 (Fast Muscle Fibers)
#TheArtsofMars #martialarts #assassin #oc #ocart #originalcharacter #Gilf
Age: 72
Height: 5'9
Country: Unknown (Presumably China)
Fighting Style: Silent Claw (静爪 Jìng Zhǎo)
Genetic Mutation's: Rapid Nail Growth and Actn3 (Fast Muscle Fibers)
#TheArtsofMars #martialarts #assassin #oc #ocart #originalcharacter #Gilf
“Experts say [it’s] nearly impossible to determine what gives any person an advantage…it is hard to determine whether testosterone exposure that a trans woman would have before transition, provides more of an advantage than a person who was born tall…or [has] a variant of the ACTN3 or ACE genes”
November 30, 2024 at 9:22 PM
“Experts say [it’s] nearly impossible to determine what gives any person an advantage…it is hard to determine whether testosterone exposure that a trans woman would have before transition, provides more of an advantage than a person who was born tall…or [has] a variant of the ACTN3 or ACE genes”
Muscle Composition and the ACTN3 Gene
A Cell Biology Perspective with Clinical Connections
swaresearch.blogspot.com/2026/04/musc...
A Cell Biology Perspective with Clinical Connections
swaresearch.blogspot.com/2026/04/musc...
Muscle Composition and the ACTN3 Gene
swaresearch.blogspot.com
April 30, 2026 at 8:10 AM
Muscle Composition and the ACTN3 Gene
A Cell Biology Perspective with Clinical Connections
swaresearch.blogspot.com/2026/04/musc...
A Cell Biology Perspective with Clinical Connections
swaresearch.blogspot.com/2026/04/musc...
Det er nettopp det. Toppidrettsutøvere har så og si alltid en «unormal» medfødt fordel som gjør at det klaffer og de blir best i akkurat sin idrett. Basketspilleres høyde. Svømmeres armspenn. Eller om man har ACTN3 eller ACE gener, som påvirker styrke og utholdenhet.
August 2, 2025 at 10:17 AM
Det er nettopp det. Toppidrettsutøvere har så og si alltid en «unormal» medfødt fordel som gjør at det klaffer og de blir best i akkurat sin idrett. Basketspilleres høyde. Svømmeres armspenn. Eller om man har ACTN3 eller ACE gener, som påvirker styrke og utholdenhet.
A study of 422 COVID-19 patients in Turkey found variations in sports-related genes (ACE, ACTN3, PPARGC1A) influenced severity.
ACE and ACTN3 offered protection, while PPARGC1A increased risk, highlighting genetics’ role in outcomes.
www.researchsquare.com/article/rs-5...
ACE and ACTN3 offered protection, while PPARGC1A increased risk, highlighting genetics’ role in outcomes.
www.researchsquare.com/article/rs-5...
The distribution of sport performance gene variations through COVID-19 disease severity
Background Since its emergence in 2020, researchers worldwide have been collaborating to better understand the SARS-CoV-2 disease’s pathophysiology. Disease severity can vary based on several fa...
www.researchsquare.com
December 24, 2024 at 7:33 PM
A study of 422 COVID-19 patients in Turkey found variations in sports-related genes (ACE, ACTN3, PPARGC1A) influenced severity.
ACE and ACTN3 offered protection, while PPARGC1A increased risk, highlighting genetics’ role in outcomes.
www.researchsquare.com/article/rs-5...
ACE and ACTN3 offered protection, while PPARGC1A increased risk, highlighting genetics’ role in outcomes.
www.researchsquare.com/article/rs-5...
If they can find a way to last 25 years, maybe we'll get genetically engineered super humans in the games. Give everybody ACTN3.
May 26, 2026 at 2:51 AM
If they can find a way to last 25 years, maybe we'll get genetically engineered super humans in the games. Give everybody ACTN3.
No te digo??? Baloncesto, brazos largos, ACTN3... pero me había saltado el párrafo de la natación entero, de verdad que estoy cada día peor!!!!! 🤦🏻♀️
March 27, 2026 at 3:01 PM
No te digo??? Baloncesto, brazos largos, ACTN3... pero me había saltado el párrafo de la natación entero, de verdad que estoy cada día peor!!!!! 🤦🏻♀️
ACTN3 genotype influences androgen response in skeletal muscle https://www.biorxiv.org/content/10.1101/2024.04.25.591034v1
ACTN3 genotype influences androgen response in skeletal muscle https://www.biorxiv.org/content/10.1101/2024.04.25.591034v1
Androgens are vital for the maintenance of muscle mass and their anabolic effects are primarily exer
www.biorxiv.org
April 28, 2024 at 7:16 PM
ACTN3 genotype influences androgen response in skeletal muscle https://www.biorxiv.org/content/10.1101/2024.04.25.591034v1
So that is why I prefer genetic engineering to mutate LRP5, BMP2, reinforce ACTN3, UCP1, PPARa, and edit PIEZO2 then our LGBTQ+ can just fly out of those Maga to the sky.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
March 14, 2025 at 4:26 PM
So that is why I prefer genetic engineering to mutate LRP5, BMP2, reinforce ACTN3, UCP1, PPARa, and edit PIEZO2 then our LGBTQ+ can just fly out of those Maga to the sky.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
There's a handy mutation to ACTN3 gene that gives you resilience against cold including improved endurance at the cost of lower sprinting performance.
theconversation.com/your-genetic...
theconversation.com/your-genetic...
Your genetics influence how resilient you are to cold temperatures – new research
Around 1.5 billion people worldwide have this common genetic variant.
theconversation.com
November 18, 2024 at 11:10 AM
There's a handy mutation to ACTN3 gene that gives you resilience against cold including improved endurance at the cost of lower sprinting performance.
theconversation.com/your-genetic...
theconversation.com/your-genetic...
Right. And what needs to be established (I think) is that the advantage is on the level of a "category" advantage not regular genetic advantage (so compare e.g. the ACTN3 gene).
April 19, 2026 at 1:47 AM
Right. And what needs to be established (I think) is that the advantage is on the level of a "category" advantage not regular genetic advantage (so compare e.g. the ACTN3 gene).
There are well-documented genetic variations that give people "unfair" advantages in many different areas, for example, the ACTN3 gene. Do you want to go full Harrison Bergeron and tie weights to athletes with a genetic edge?
September 11, 2026 at 3:06 PM
There are well-documented genetic variations that give people "unfair" advantages in many different areas, for example, the ACTN3 gene. Do you want to go full Harrison Bergeron and tie weights to athletes with a genetic edge?
📖 Want to learn more about muscle genetics & training? Read the study here:
www.sciencedirect.co...
#Sarcopenia #StrengthTraining #Genetics #ACTN3 #Epigenetics #MuscleHealth
www.sciencedirect.co...
#Sarcopenia #StrengthTraining #Genetics #ACTN3 #Epigenetics #MuscleHealth
Progressive strength training can reverse sarcopenia stage in middle-aged and older adults regardless of their genetic profile
The aim of this study was to verify the association of the ACTN3-R577X polymorphism with sarcopenia stage, according to the Revised European Consensus…
www.sciencedirect.com
February 15, 2025 at 2:44 PM
📖 Want to learn more about muscle genetics & training? Read the study here:
www.sciencedirect.co...
#Sarcopenia #StrengthTraining #Genetics #ACTN3 #Epigenetics #MuscleHealth
www.sciencedirect.co...
#Sarcopenia #StrengthTraining #Genetics #ACTN3 #Epigenetics #MuscleHealth
これ、読みました。
「ACTN3遺伝子がスプリント能力に影響を与えているように見えるとはいえ、それだけでスポーツを選択してしまうのは、一つのピースを見ただけでジグソーパズルの全体図を決めてしまうようなものだ。（p.211）——エプスタイン著『スポーツ遺伝子は勝者を決めるか?』」
であると信じたいですね。
「ACTN3遺伝子がスプリント能力に影響を与えているように見えるとはいえ、それだけでスポーツを選択してしまうのは、一つのピースを見ただけでジグソーパズルの全体図を決めてしまうようなものだ。（p.211）——エプスタイン著『スポーツ遺伝子は勝者を決めるか?』」
であると信じたいですね。
February 14, 2026 at 12:04 PM
これ、読みました。
「ACTN3遺伝子がスプリント能力に影響を与えているように見えるとはいえ、それだけでスポーツを選択してしまうのは、一つのピースを見ただけでジグソーパズルの全体図を決めてしまうようなものだ。（p.211）——エプスタイン著『スポーツ遺伝子は勝者を決めるか?』」
であると信じたいですね。
「ACTN3遺伝子がスプリント能力に影響を与えているように見えるとはいえ、それだけでスポーツを選択してしまうのは、一つのピースを見ただけでジグソーパズルの全体図を決めてしまうようなものだ。（p.211）——エプスタイン著『スポーツ遺伝子は勝者を決めるか?』」
であると信じたいですね。
💡 3. Multiple Genes Influence a Single Trait
✅ Strength, power, & sarcopenia risk aren’t controlled by a single gene like ACTN3.
✅ Other genes in muscle protein synthesis, metabolism, and inflammation influence training responses.
✅ Strength, power, & sarcopenia risk aren’t controlled by a single gene like ACTN3.
✅ Other genes in muscle protein synthesis, metabolism, and inflammation influence training responses.
February 15, 2025 at 2:44 PM
💡 3. Multiple Genes Influence a Single Trait
✅ Strength, power, & sarcopenia risk aren’t controlled by a single gene like ACTN3.
✅ Other genes in muscle protein synthesis, metabolism, and inflammation influence training responses.
✅ Strength, power, & sarcopenia risk aren’t controlled by a single gene like ACTN3.
✅ Other genes in muscle protein synthesis, metabolism, and inflammation influence training responses.
📢 Takeaway:
While ACTN3-R577X influences muscle fiber composition & power, it does not dictate muscle function or sarcopenia risk.
🏋️ Strength training is universally beneficial—regardless of genetics.
🔥 Your training & lifestyle matter more than your genes.
While ACTN3-R577X influences muscle fiber composition & power, it does not dictate muscle function or sarcopenia risk.
🏋️ Strength training is universally beneficial—regardless of genetics.
🔥 Your training & lifestyle matter more than your genes.
February 15, 2025 at 2:44 PM
📢 Takeaway:
While ACTN3-R577X influences muscle fiber composition & power, it does not dictate muscle function or sarcopenia risk.
🏋️ Strength training is universally beneficial—regardless of genetics.
🔥 Your training & lifestyle matter more than your genes.
While ACTN3-R577X influences muscle fiber composition & power, it does not dictate muscle function or sarcopenia risk.
🏋️ Strength training is universally beneficial—regardless of genetics.
🔥 Your training & lifestyle matter more than your genes.
The ACTN3-R577X polymorphism is one of the most well-studied genetic variations in muscle function & athletic performance. It affects α-actinin-3, a protein in fast-twitch (type II) muscle fibers, which are key for explosive strength & power movements.
February 15, 2025 at 2:43 PM
The ACTN3-R577X polymorphism is one of the most well-studied genetic variations in muscle function & athletic performance. It affects α-actinin-3, a protein in fast-twitch (type II) muscle fibers, which are key for explosive strength & power movements.
💡 1. Environmental & Lifestyle Factors Matter More
✅ Strength training (ST) overrides genetic predisposition—in the ACTN3 study, individuals reversed sarcopenia w ST, regardless of genotype.
✅ Diet, activity, sleep, recovery also modify gene expression & impact muscle health.
✅ Strength training (ST) overrides genetic predisposition—in the ACTN3 study, individuals reversed sarcopenia w ST, regardless of genotype.
✅ Diet, activity, sleep, recovery also modify gene expression & impact muscle health.
February 15, 2025 at 2:43 PM
💡 1. Environmental & Lifestyle Factors Matter More
✅ Strength training (ST) overrides genetic predisposition—in the ACTN3 study, individuals reversed sarcopenia w ST, regardless of genotype.
✅ Diet, activity, sleep, recovery also modify gene expression & impact muscle health.
✅ Strength training (ST) overrides genetic predisposition—in the ACTN3 study, individuals reversed sarcopenia w ST, regardless of genotype.
✅ Diet, activity, sleep, recovery also modify gene expression & impact muscle health.
Genotype Doesn’t Always Predict Phenotype—Here’s Why
Your genetics don’t dictate your muscle function or sarcopenia risk as much as you might think. The ACTN3-R577X study reinforces a key principle in genetics: genotype ≠ phenotype.
Let’s break it down. 🧵👇
Your genetics don’t dictate your muscle function or sarcopenia risk as much as you might think. The ACTN3-R577X study reinforces a key principle in genetics: genotype ≠ phenotype.
Let’s break it down. 🧵👇
February 15, 2025 at 2:43 PM
Genotype Doesn’t Always Predict Phenotype—Here’s Why
Your genetics don’t dictate your muscle function or sarcopenia risk as much as you might think. The ACTN3-R577X study reinforces a key principle in genetics: genotype ≠ phenotype.
Let’s break it down. 🧵👇
Your genetics don’t dictate your muscle function or sarcopenia risk as much as you might think. The ACTN3-R577X study reinforces a key principle in genetics: genotype ≠ phenotype.
Let’s break it down. 🧵👇