Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 1:27 AM
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
AIM2 promotes airway hyperresponsiveness and lung inflammation by enhancing type II cytokines, immune cell populations, and the DNA damage response @pnas.org @ting-lab-unc.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
August 19, 2026 at 4:08 PM
イムさん(@aim2.bsky.social )に頂いたロールケーキ！ありがとうございますー！！
紅茶と共にいただきます
紅茶と共にいただきます
May 26, 2025 at 12:38 PM
イムさん(@aim2.bsky.social )に頂いたロールケーキ！ありがとうございますー！！
紅茶と共にいただきます
紅茶と共にいただきます
I heard there's a protein called AIM2.
It better not be dependent on Aim 1.
It better not be dependent on Aim 1.
March 19, 2026 at 8:09 AM
I heard there's a protein called AIM2.
It better not be dependent on Aim 1.
It better not be dependent on Aim 1.
A paper using RRID:AB_469576 from @thermofishersci.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #BetterScience #accelerateopenscience #OpenScience
AIM2 in tregs restrains anti-PD-1 efficacy by reinforcing immune suppression in MC38 colorectal cancer
Read the full paper: AIM2 in tregs restrains anti-PD-1 efficacy by reinforcing immune suppression in MC38 colorectal cancer
doi.org
September 28, 2026 at 7:00 AM
A paper using RRID:AB_469576 from @thermofishersci.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #BetterScience #accelerateopenscience #OpenScience
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 7:29 PM
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The alkylation of AIM2 by itaconate mediates macrophage PANoptosis during sepsis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 12, 2026 at 4:52 PM
The alkylation of AIM2 by itaconate mediates macrophage PANoptosis during sepsis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@biorxivpreprint.bsky.social DNA-triggered AIM2 condensation orchestrates immune activation and regulation
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 21, 2026 at 11:55 PM
@biorxivpreprint.bsky.social DNA-triggered AIM2 condensation orchestrates immune activation and regulation
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
2024.11.10
XANVALA × NICOLAS AIM2 @ 名古屋
朔さんと巽さん🐊
XANVALA × NICOLAS AIM2 @ 名古屋
朔さんと巽さん🐊
November 14, 2024 at 2:06 AM
2024.11.10
XANVALA × NICOLAS AIM2 @ 名古屋
朔さんと巽さん🐊
XANVALA × NICOLAS AIM2 @ 名古屋
朔さんと巽さん🐊
お菓子ありがとう～～～！ゆっくりいただきます @aim2.bsky.social
March 22, 2025 at 3:58 PM
お菓子ありがとう～～～！ゆっくりいただきます @aim2.bsky.social
ぶるーすかいおみくじ | Bluesky
Blueskyアカウントでおみくじが引けます（毎年結果が変わります）
oracle.heion.net
December 27, 2025 at 1:06 PM
Our paper about cryptanalysis of AIM2 is on the front page of eprint 😀 Look for tomorrow's presentation at #Eurocrypt 2026. I will share more details later. ia.cr/2026/903
Cryptology ePrint Archive
The Cryptology ePrint Archive provides rapid access to recent research in cryptology.
eprint.iacr.org
May 10, 2026 at 11:28 AM
Our paper about cryptanalysis of AIM2 is on the front page of eprint 😀 Look for tomorrow's presentation at #Eurocrypt 2026. I will share more details later. ia.cr/2026/903
A query: cGAS, STING, AIM2, NODs, NLRs, RLRs: All these PRRs are categorized as pathogen sensors, because they reside in the cytoplasm. In contrast, TLRs sense non-pathogens and pathogens. How confirmed is this dogma, beyond the usual (small) set of pathogens that we all study?
July 16, 2026 at 4:50 PM
A query: cGAS, STING, AIM2, NODs, NLRs, RLRs: All these PRRs are categorized as pathogen sensors, because they reside in the cytoplasm. In contrast, TLRs sense non-pathogens and pathogens. How confirmed is this dogma, beyond the usual (small) set of pathogens that we all study?
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 20, 2026 at 3:18 PM
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
....slowly easing back into climbing....very slow. Just getting here took some time.
Goal: climb midway with controlled descent.
Aim1. Put climbing shoes on
Aim2. Chalk up hands
Aim3. Just do it.
Goal: climb midway with controlled descent.
Aim1. Put climbing shoes on
Aim2. Chalk up hands
Aim3. Just do it.
May 17, 2026 at 12:53 PM
....slowly easing back into climbing....very slow. Just getting here took some time.
Goal: climb midway with controlled descent.
Aim1. Put climbing shoes on
Aim2. Chalk up hands
Aim3. Just do it.
Goal: climb midway with controlled descent.
Aim1. Put climbing shoes on
Aim2. Chalk up hands
Aim3. Just do it.
The viral BCL2 protein BHRF1 of Epstein–Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
September 25, 2025 at 2:27 AM
The viral BCL2 protein BHRF1 of Epstein–Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
ぶるーすかいおみくじ | Bluesky
Blueskyアカウントでおみくじが引けます（毎年結果が変わります）
oracle.heion.net
December 31, 2025 at 3:33 PM
ぶるーすかいおみくじの結果は「大吉」でした。 oracle.heion.net?handle=aim2....
やったー大吉‼️‼️‼️🙌🙌🙌🙌🙌
やったー大吉‼️‼️‼️🙌🙌🙌🙌🙌
ぶるーすかいおみくじ | Bluesky
Blueskyアカウントでおみくじが引けます（毎年結果が変わります）
oracle.heion.net
January 2, 2025 at 2:42 PM
ぶるーすかいおみくじの結果は「大吉」でした。 oracle.heion.net?handle=aim2....
やったー大吉‼️‼️‼️🙌🙌🙌🙌🙌
やったー大吉‼️‼️‼️🙌🙌🙌🙌🙌
A paper using RRID:AB_11042321 from @proteintech.bsky.social was just published in Cell Reports. RRIDs improve reproducibility in scientific research. #OpenScience #BetterScience #STMpublishing
Unified phase separation drives DNA-induced inflammasome activation of the AIM2-like receptors
Read the full paper: Unified phase separation drives DNA-induced inflammasome activation of the AIM2-like receptors
doi.org
March 18, 2026 at 7:00 AM
A paper using RRID:AB_11042321 from @proteintech.bsky.social was just published in Cell Reports. RRIDs improve reproducibility in scientific research. #OpenScience #BetterScience #STMpublishing
... identified #nanobodies that block AIM2 inflammasomes by interfering with AIM2 Pyrin filament oligomerization (sequences deposited in nanosaurus.org data base) ...
January 21, 2026 at 1:45 AM
... identified #nanobodies that block AIM2 inflammasomes by interfering with AIM2 Pyrin filament oligomerization (sequences deposited in nanosaurus.org data base) ...
www.nature.com/articles/s41...
Really insightful work by Sharma and de Alba on assembly of the AIM2 inflammasome.
Really insightful work by Sharma and de Alba on assembly of the AIM2 inflammasome.
December 8, 2023 at 11:45 AM
www.nature.com/articles/s41...
Really insightful work by Sharma and de Alba on assembly of the AIM2 inflammasome.
Really insightful work by Sharma and de Alba on assembly of the AIM2 inflammasome.
Beyond AIM2, systems biology revealed suggestive loci linked to innate immunity mediated by #monocytes and #NK cells (KLRs and NCR3), upstream cytokines IL-6 and IFN-γ, neuronal pathways (AUTS2, NGF, NPAS3), and lipid metabolism (LDLR, CD36, HMGCR, LPIN2), experimentally validated in #metabolomics
June 5, 2025 at 8:33 PM
Beyond AIM2, systems biology revealed suggestive loci linked to innate immunity mediated by #monocytes and #NK cells (KLRs and NCR3), upstream cytokines IL-6 and IFN-γ, neuronal pathways (AUTS2, NGF, NPAS3), and lipid metabolism (LDLR, CD36, HMGCR, LPIN2), experimentally validated in #metabolomics
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
September 26, 2025 at 2:02 PM
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social