1/ Some cancers can proliferate without telomerase. They recombine and extend their telomeres inside ALT-associated PML bodies (APBs). @emmakoeleman.bsky.social @dkfz.bsky.social mapped where proteins and single-stranded telomeric repeats sit in APBs: doi.org/10.64898/202... 🧵
May 14, 2026 at 10:00 PM
1/ Some cancers can proliferate without telomerase. They recombine and extend their telomeres inside ALT-associated PML bodies (APBs). @emmakoeleman.bsky.social @dkfz.bsky.social mapped where proteins and single-stranded telomeric repeats sit in APBs: doi.org/10.64898/202... 🧵
in approx. 10 minutes! gonna let the machine warm up first before we begin the venture :3
twitch.tv/wolfieamel
#APBS #AÖRD
twitch.tv/wolfieamel
#APBS #AÖRD
This is for tonight~ catch me if you would :3
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD
September 29, 2026 at 11:05 AM
in approx. 10 minutes! gonna let the machine warm up first before we begin the venture :3
twitch.tv/wolfieamel
#APBS #AÖRD
twitch.tv/wolfieamel
#APBS #AÖRD
If it wasn’t them then there should be APBs out on these guys. I’ll wait.
June 19, 2025 at 10:36 PM
If it wasn’t them then there should be APBs out on these guys. I’ll wait.
Been generally quiet tonight because as usual.. i nearly forgor (and been messing around FreeCAD all day haha)
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
October 1, 2026 at 1:49 PM
Here’s a belter of a photo sent in APBs George!
Buttery V Rothko.
Lot of yella going on!
Buttery V Rothko.
Lot of yella going on!
September 16, 2026 at 8:03 PM
Here’s a belter of a photo sent in APBs George!
Buttery V Rothko.
Lot of yella going on!
Buttery V Rothko.
Lot of yella going on!
I'm going to implore everyone finding out about Zach Rosenberg being a serial problem to not assume everyone is as terminally online as you are. I certainly didn't know and I usually DO get the APBs. Assuming the worst of everyone will bite you in the ass eventually.
April 15, 2024 at 9:49 PM
I'm going to implore everyone finding out about Zach Rosenberg being a serial problem to not assume everyone is as terminally online as you are. I certainly didn't know and I usually DO get the APBs. Assuming the worst of everyone will bite you in the ass eventually.
“I thought you DOGED the NSF out of existence.”
“So did I. Must’ve missed one.” He scanned the ballroom. “Seriously. Where is he? Should we send an APB? Do they even have APBs in this country?” #WIPSnips
“So did I. Must’ve missed one.” He scanned the ballroom. “Seriously. Where is he? Should we send an APB? Do they even have APBs in this country?” #WIPSnips
Happy FriYAY!
The #WIPSnips word for February 13th is "serious"
#WriteSky #WritingCommunity #WritingPrompts
The #WIPSnips word for February 13th is "serious"
#WriteSky #WritingCommunity #WritingPrompts
February 13, 2026 at 12:20 PM
“I thought you DOGED the NSF out of existence.”
“So did I. Must’ve missed one.” He scanned the ballroom. “Seriously. Where is he? Should we send an APB? Do they even have APBs in this country?” #WIPSnips
“So did I. Must’ve missed one.” He scanned the ballroom. “Seriously. Where is he? Should we send an APB? Do they even have APBs in this country?” #WIPSnips
I'm so old I can remember when police (on TV) issued APBs not BOLOs.
January 8, 2026 at 7:50 PM
I'm so old I can remember when police (on TV) issued APBs not BOLOs.
not me forgetting to start live because of lumity memes, anyway, live now
Not so Productive Week | WochenSpiegel
twitch.tv/wolfieamel
#APBS #AÖRD
Not so Productive Week | WochenSpiegel
twitch.tv/wolfieamel
#APBS #AÖRD
September 26, 2026 at 1:06 PM
not me forgetting to start live because of lumity memes, anyway, live now
Not so Productive Week | WochenSpiegel
twitch.tv/wolfieamel
#APBS #AÖRD
Not so Productive Week | WochenSpiegel
twitch.tv/wolfieamel
#APBS #AÖRD
nah. i've seen the world outside the heckin' doggos and we need to go BACK to cats pushing watermelons out of lakes, asking for cheezburgers and walruses sending out apbs for buckets
i'm sorry but no, i know what we had and i know what we have and no, we need to go back
i'm sorry but no, i know what we had and i know what we have and no, we need to go back
September 18, 2026 at 11:04 PM
nah. i've seen the world outside the heckin' doggos and we need to go BACK to cats pushing watermelons out of lakes, asking for cheezburgers and walruses sending out apbs for buckets
i'm sorry but no, i know what we had and i know what we have and no, we need to go back
i'm sorry but no, i know what we had and i know what we have and no, we need to go back
Congratulations to our Director of Training & Technical Assistance Kelcey Schmitz for receiving the APBS 2025 Ted Carr Practitioner Award! 🥳
And shout out to our RIISE Fellow Aaron R. Campbell for receiving the APBS 2025 Ted Carr Initial Research Award!
And shout out to our RIISE Fellow Aaron R. Campbell for receiving the APBS 2025 Ted Carr Initial Research Award!
2025 APBS Award Recipients
Let's meet the fantastic 2025 recipients of the APBS Awards who will be honored at the #APBS25 Conference on March 12-15, 2025, in St. Louis.
bit.ly
February 27, 2025 at 6:36 PM
Congratulations to our Director of Training & Technical Assistance Kelcey Schmitz for receiving the APBS 2025 Ted Carr Practitioner Award! 🥳
And shout out to our RIISE Fellow Aaron R. Campbell for receiving the APBS 2025 Ted Carr Initial Research Award!
And shout out to our RIISE Fellow Aaron R. Campbell for receiving the APBS 2025 Ted Carr Initial Research Award!
bluesky would be doing just fine if the tulsa police force was doing their APBs on here and a democratic-run department of homeland security.
May 19, 2026 at 2:23 PM
bluesky would be doing just fine if the tulsa police force was doing their APBs on here and a democratic-run department of homeland security.
This guy does these absurd APBs to NYPD who aren’t reading his posts to claim I’m going to cause problems or create fake scenarios when in reality I’m at the beach tit-deep in the big blue with my baby who is, to my surprise, having a blast in the ocean.
June 28, 2026 at 7:58 PM
This guy does these absurd APBs to NYPD who aren’t reading his posts to claim I’m going to cause problems or create fake scenarios when in reality I’m at the beach tit-deep in the big blue with my baby who is, to my surprise, having a blast in the ocean.
also, book reading tonight
lets hope the book reader will work, else i'll just read it from my tablet.
21:00 Jakarta
twitch.tv/wolfieamel
#AÖRD #APBS
lets hope the book reader will work, else i'll just read it from my tablet.
21:00 Jakarta
twitch.tv/wolfieamel
#AÖRD #APBS
September 24, 2026 at 9:45 AM
also, book reading tonight
lets hope the book reader will work, else i'll just read it from my tablet.
21:00 Jakarta
twitch.tv/wolfieamel
#AÖRD #APBS
lets hope the book reader will work, else i'll just read it from my tablet.
21:00 Jakarta
twitch.tv/wolfieamel
#AÖRD #APBS
in 15 Minutes : That one game Farming Game™ with British Petrol Reference | After Afternoon
twitch.tv/wolfieamel
#APBS #AÖRD
twitch.tv/wolfieamel
#APBS #AÖRD
Good morning, i'll see you all in a few horus
i'm still soo eepy orzzzZZ
After Afternoon 18:15 JKT
playing coris
twitch.tv/wolfieamel
#APBS #AÖRD
i'm still soo eepy orzzzZZ
After Afternoon 18:15 JKT
playing coris
twitch.tv/wolfieamel
#APBS #AÖRD
September 22, 2026 at 11:01 AM
in 15 Minutes : That one game Farming Game™ with British Petrol Reference | After Afternoon
twitch.tv/wolfieamel
#APBS #AÖRD
twitch.tv/wolfieamel
#APBS #AÖRD
APBS
Assigned Pakistani By Strangers
Congrats on the new gender!
Assigned Pakistani By Strangers
Congrats on the new gender!
May 3, 2025 at 10:24 AM
APBS
Assigned Pakistani By Strangers
Congrats on the new gender!
Assigned Pakistani By Strangers
Congrats on the new gender!
APBs have been issued for Isaiah Thomas, John Salley, and Joeeeee DuuuuuuMaaaaars!
August 6, 2026 at 8:18 PM
APBs have been issued for Isaiah Thomas, John Salley, and Joeeeee DuuuuuuMaaaaars!
I dinnae forget that i have accountability stream tonight, in fact i am preparing for something fun and some of you might be interested in that~
Wochenspiegel
20:15 Jakarta / 14:15 London
twitch.tv/wolfieamel
#APBS #AÖRD
Wochenspiegel
20:15 Jakarta / 14:15 London
twitch.tv/wolfieamel
#APBS #AÖRD
September 26, 2026 at 11:19 AM
I dinnae forget that i have accountability stream tonight, in fact i am preparing for something fun and some of you might be interested in that~
Wochenspiegel
20:15 Jakarta / 14:15 London
twitch.tv/wolfieamel
#APBS #AÖRD
Wochenspiegel
20:15 Jakarta / 14:15 London
twitch.tv/wolfieamel
#APBS #AÖRD
September 19, 2026 at 1:11 PM
They will merge voter rolls into indictments, put out APBs, and circulate them at 'Fusion Centers' where local law enforcement in an informal information sharing environment, will pick them up, coordinate with JTTF to track and kidnap you, as they have been training to do with ICE.
September 24, 2026 at 2:40 PM
They will merge voter rolls into indictments, put out APBs, and circulate them at 'Fusion Centers' where local law enforcement in an informal information sharing environment, will pick them up, coordinate with JTTF to track and kidnap you, as they have been training to do with ICE.
Been generally quiet tonight because as usual.. i nearly forgor (and been messing around FreeCAD all day haha)
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
October 1, 2026 at 12:06 PM
Been generally quiet tonight because as usual.. i nearly forgor (and been messing around FreeCAD all day haha)
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
But, with thunderstorm around here, if things gone well we'll be reading 1984 by george orwell, later at 21:00 Jakarta Time.
twitch.tv/wolfieamel
#APBS #AORD
Indeed.
"As outlined in Weapons, Tactics and Capability, the deliberate use of violence against ideological opponents, and in service of ideological objectives has been a key characteristic of the APBs since its founding by McInnes.
..
“We will kill you. That’s the Proud Boys in a nutshell""
#nzpol
"As outlined in Weapons, Tactics and Capability, the deliberate use of violence against ideological opponents, and in service of ideological objectives has been a key characteristic of the APBs since its founding by McInnes.
..
“We will kill you. That’s the Proud Boys in a nutshell""
#nzpol
September 4, 2025 at 2:57 AM
Indeed.
"As outlined in Weapons, Tactics and Capability, the deliberate use of violence against ideological opponents, and in service of ideological objectives has been a key characteristic of the APBs since its founding by McInnes.
..
“We will kill you. That’s the Proud Boys in a nutshell""
#nzpol
"As outlined in Weapons, Tactics and Capability, the deliberate use of violence against ideological opponents, and in service of ideological objectives has been a key characteristic of the APBs since its founding by McInnes.
..
“We will kill you. That’s the Proud Boys in a nutshell""
#nzpol
We explored the role of the telomeric RNA TERRA in cancer cells that transition from telomerase to ALT to maintain telomeres.
We show that TERRA levels remain unchanged, but TERRA molecules relocate to telomeres and engage in R-loops. See thread ↓
link.springer.com/article/10.1...
We show that TERRA levels remain unchanged, but TERRA molecules relocate to telomeres and engage in R-loops. See thread ↓
link.springer.com/article/10.1...
ALT induction by ASF1 depletion is associated with TERRA accumulation at telomeres and relies on R-loops - Cell Communication and Signaling
The mechanism of Alternative Lengthening of Telomeres (ALT) relies on homologous recombination processes taking place at telomeres within ALT-associated PML bodies, or APBs. ALT cells express high lev...
link.springer.com
September 24, 2026 at 9:44 PM
We explored the role of the telomeric RNA TERRA in cancer cells that transition from telomerase to ALT to maintain telomeres.
We show that TERRA levels remain unchanged, but TERRA molecules relocate to telomeres and engage in R-loops. See thread ↓
link.springer.com/article/10.1...
We show that TERRA levels remain unchanged, but TERRA molecules relocate to telomeres and engage in R-loops. See thread ↓
link.springer.com/article/10.1...
This is for tonight~ catch me if you would :3
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD
September 29, 2026 at 5:46 AM
This is for tonight~ catch me if you would :3
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD
though the real question is, can a farmer of a truck driver (me) play a story-driven RPG?
twitch.tv/wolfieamel
#APBS #AÖRD