Not just shingles vaccine, but also RSV vaccine reduces the risk of dementia, which highlights the benefit of revving up the immune system in older individuals
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 27, 2025 at 5:48 PM
Not just shingles vaccine, but also RSV vaccine reduces the risk of dementia, which highlights the benefit of revving up the immune system in older individuals
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Big find: Vaccines with AS01 adjuvant (shingles, RSV) tied to less dementia. The immune system might be fighting more than infections. www.nature.com/articles/s41...
#BlueSky #MedSky #NewsSky #SciSky 🧪 #NurseSky #IDSky #EMSky
#PedsSky #NeuroSky
#BlueSky #MedSky #NewsSky #SciSky 🧪 #NurseSky #IDSky #EMSky
#PedsSky #NeuroSky
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 27, 2025 at 10:10 PM
Do vaccines protect against dementia?
A new EHR-based study of >430,000 older adults found that AS01-adjuvanted vaccines (Shingrix for shingles & Arexvy for RSV) were associated with a lower 18-month risk of developing dementia whether given alone or together.
www.nature.com/articles/s41...
A new EHR-based study of >430,000 older adults found that AS01-adjuvanted vaccines (Shingrix for shingles & Arexvy for RSV) were associated with a lower 18-month risk of developing dementia whether given alone or together.
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
July 22, 2025 at 7:52 PM
Do vaccines protect against dementia?
A new EHR-based study of >430,000 older adults found that AS01-adjuvanted vaccines (Shingrix for shingles & Arexvy for RSV) were associated with a lower 18-month risk of developing dementia whether given alone or together.
www.nature.com/articles/s41...
A new EHR-based study of >430,000 older adults found that AS01-adjuvanted vaccines (Shingrix for shingles & Arexvy for RSV) were associated with a lower 18-month risk of developing dementia whether given alone or together.
www.nature.com/articles/s41...
AS01 induces trained immunity and is extremely reactogenic
January 11, 2025 at 4:56 PM
AS01 induces trained immunity and is extremely reactogenic
Vaccines = so many benefits.
RSV Vaccine Tied to Lower Dementia Risk www.medpagetoday.com/neurology/de...
#VaccinesWork
RSV Vaccine Tied to Lower Dementia Risk www.medpagetoday.com/neurology/de...
#VaccinesWork
RSV Vaccine Tied to Lower Dementia Risk
Arexy's AS01 adjuvant may play a role
www.medpagetoday.com
June 30, 2025 at 4:47 PM
Vaccines = so many benefits.
RSV Vaccine Tied to Lower Dementia Risk www.medpagetoday.com/neurology/de...
#VaccinesWork
RSV Vaccine Tied to Lower Dementia Risk www.medpagetoday.com/neurology/de...
#VaccinesWork
AS01 rework in progress...
#Live2DWIP
#Live2DWIP
November 22, 2024 at 7:35 PM
AS01 rework in progress...
#Live2DWIP
#Live2DWIP
Two unrelated vaccines are hugely effective against dementia. And the reason might be... the adjuvant.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 25, 2025 at 12:14 PM
Two unrelated vaccines are hugely effective against dementia. And the reason might be... the adjuvant.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
RSV infections, in addition to other infections such as VZV (Chicken pox and shingles), may contribute to dementia risk.
www.nature.com/artic...
1/3
RSV infections, in addition to other infections such as VZV (Chicken pox and shingles), may contribute to dementia risk.
www.nature.com/artic...
1/3
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 28, 2025 at 7:41 PM
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
RSV infections, in addition to other infections such as VZV (Chicken pox and shingles), may contribute to dementia risk.
www.nature.com/artic...
1/3
RSV infections, in addition to other infections such as VZV (Chicken pox and shingles), may contribute to dementia risk.
www.nature.com/artic...
1/3
Shingrix and Arexvy RSV vaccines show the same protection. They both use the same AS01 adjuvant. I would definitely do a study with just the adjuvant in younger individuals.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
February 26, 2026 at 4:42 AM
Shingrix and Arexvy RSV vaccines show the same protection. They both use the same AS01 adjuvant. I would definitely do a study with just the adjuvant in younger individuals.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I guess RFK Jr convinced him not to get his vaccine. Malaria vaccines are designed to prevent infection with the malaria parasite, Plasmodium. Currently, there are two approved malaria vaccines:
1. RTS,S/AS01 (Mosquirix)
1. RTS,S/AS01 (Mosquirix)
Oh just great.
Fox News Host Reveals He Has Malaria
Fox News Host Reveals He Has Malaria
Fox News Host Reveals He Has Malaria
A fixture on Fox News’ America Reports is down with a “severe” case of the mosquito-transmitted disease.
www.thedailybeast.com
August 27, 2025 at 8:21 PM
I guess RFK Jr convinced him not to get his vaccine. Malaria vaccines are designed to prevent infection with the malaria parasite, Plasmodium. Currently, there are two approved malaria vaccines:
1. RTS,S/AS01 (Mosquirix)
1. RTS,S/AS01 (Mosquirix)
2 vaccines for different pathogens—the respiratory syncytial virus vaccine—& the recombinant shingles vaccine—are associated w/ lower dementia risk, according to an analysis of over 400k older U.S. adults. The RSV vax is sold as Arexvy. The shingles vax is sold as Shingrix👇
RSV Vaccine Tied to Lower Dementia Risk
Arexy's AS01 adjuvant may play a role
www.medpagetoday.com
June 29, 2025 at 3:28 PM
2 vaccines for different pathogens—the respiratory syncytial virus vaccine—& the recombinant shingles vaccine—are associated w/ lower dementia risk, according to an analysis of over 400k older U.S. adults. The RSV vax is sold as Arexvy. The shingles vax is sold as Shingrix👇
It occurs to me that I should probably offer a bit of evidence:
General background: www.nature.com/articles/s41...
AS01:
www.sciencedirect.com/science/arti...
www.tandfonline.com/doi/full/10....
Trained immunity:
www.science.org/doi/10.1126/...
General background: www.nature.com/articles/s41...
AS01:
www.sciencedirect.com/science/arti...
www.tandfonline.com/doi/full/10....
Trained immunity:
www.science.org/doi/10.1126/...
Adjuvant AS01 activates human monocytes for costimulation and systemic inflammation
The adjuvanted recombinant zoster vaccine (RZV) is highly effective even in adults over 80 years old. The high efficacy of RZV is attributed to its hi…
www.sciencedirect.com
January 11, 2025 at 11:52 PM
It occurs to me that I should probably offer a bit of evidence:
General background: www.nature.com/articles/s41...
AS01:
www.sciencedirect.com/science/arti...
www.tandfonline.com/doi/full/10....
Trained immunity:
www.science.org/doi/10.1126/...
General background: www.nature.com/articles/s41...
AS01:
www.sciencedirect.com/science/arti...
www.tandfonline.com/doi/full/10....
Trained immunity:
www.science.org/doi/10.1126/...
www.passporthealthusa.com/2025/11/two-.... THE SHINGLES VACCINE IN COMBINATION WITH THE RSV VACCINE REDUCE THE RISK OF DEMENTIA BY UP TO 38% !
Two Popular Vaccines Show Surprising Protection Against Dementia | Passport Health
AS01-adjuvanted vaccines may offer unexpected protection against dementia. These findings could help shape future strategies for dementia prevention.
www.passporthealthusa.com
June 28, 2026 at 10:02 PM
www.passporthealthusa.com/2025/11/two-.... THE SHINGLES VACCINE IN COMBINATION WITH THE RSV VACCINE REDUCE THE RISK OF DEMENTIA BY UP TO 38% !
December 26, 2025 at 10:47 PM
While immunocompromised individuals had a heterogeneous antibody response to RSV vaccines, those who received the adjuvanted RSVPreF3-AS01 vaccine showed better neutralization.
ja.ma/4iVzJzy
ja.ma/4iVzJzy
December 30, 2024 at 6:25 PM
While immunocompromised individuals had a heterogeneous antibody response to RSV vaccines, those who received the adjuvanted RSVPreF3-AS01 vaccine showed better neutralization.
ja.ma/4iVzJzy
ja.ma/4iVzJzy
As some others have mentioned, it’s the AS01 adjuvant, a mixture of an extract from the Chilean soapbark tree and some bacterial lipids. It really revs up the immune response, but yeah, you definitely feel it kick in.
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity - npj Vaccines
A mechanism is revealed by which vaccine components co-operate to stimulate the immune system and improve vaccine efficacy. Some vaccines are formulated with adjuvants—compounds that induce a greater ...
www.nature.com
January 12, 2025 at 1:35 AM
As some others have mentioned, it’s the AS01 adjuvant, a mixture of an extract from the Chilean soapbark tree and some bacterial lipids. It really revs up the immune response, but yeah, you definitely feel it kick in.
One hypothesis is that the AS01 adjuvant in the recombinant vaccine may reprogram innate immune responses and reduce inflammatory pathways linked to cardiovascular disease. That remains speculative.
August 26, 2026 at 4:30 PM
One hypothesis is that the AS01 adjuvant in the recombinant vaccine may reprogram innate immune responses and reduce inflammatory pathways linked to cardiovascular disease. That remains speculative.
Compared to flu vaccination:
- Shingles vaccine = 18% lower dementia risk
- RSV vaccine = 29% lower
- Both vaccines = 37% lower
Strikingly, the protection was not additive, pointing to a shared mechanism, likely the AS01 adjuvant itself, not just infection prevention.
- Shingles vaccine = 18% lower dementia risk
- RSV vaccine = 29% lower
- Both vaccines = 37% lower
Strikingly, the protection was not additive, pointing to a shared mechanism, likely the AS01 adjuvant itself, not just infection prevention.
July 22, 2025 at 7:52 PM
Compared to flu vaccination:
- Shingles vaccine = 18% lower dementia risk
- RSV vaccine = 29% lower
- Both vaccines = 37% lower
Strikingly, the protection was not additive, pointing to a shared mechanism, likely the AS01 adjuvant itself, not just infection prevention.
- Shingles vaccine = 18% lower dementia risk
- RSV vaccine = 29% lower
- Both vaccines = 37% lower
Strikingly, the protection was not additive, pointing to a shared mechanism, likely the AS01 adjuvant itself, not just infection prevention.
what appears so special about the AS01 adjuvant in Shingrix that decreases Alzheimers?
September 23, 2025 at 11:25 AM
what appears so special about the AS01 adjuvant in Shingrix that decreases Alzheimers?
How might AS01 work? It contains MPL (a TLR4 agonist) and QS-21, which activate dendritic cells and trigger IFN-γ responses, factors implicated in reducing amyloid pathology and slowing cognitive decline in prior studies.
An intriguing immunologic pathway for neuro-protection worth exploring.
An intriguing immunologic pathway for neuro-protection worth exploring.
July 22, 2025 at 7:52 PM
How might AS01 work? It contains MPL (a TLR4 agonist) and QS-21, which activate dendritic cells and trigger IFN-γ responses, factors implicated in reducing amyloid pathology and slowing cognitive decline in prior studies.
An intriguing immunologic pathway for neuro-protection worth exploring.
An intriguing immunologic pathway for neuro-protection worth exploring.
En hypotes att det är adjuvanten AS01 i shingrix som ffa skyddar mot demens, då RSV-vaccinet med samma adjuvant visar samma trend.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 27, 2025 at 7:29 PM
En hypotes att det är adjuvanten AS01 i shingrix som ffa skyddar mot demens, då RSV-vaccinet med samma adjuvant visar samma trend.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Grote vondst: Vaccins met AS01 hulpstof (gordelroos, RSV) gekoppeld aan minder dementie. Het immuunsysteem vecht misschien tegen meer dan alleen infecties. www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 28, 2025 at 1:45 PM
Grote vondst: Vaccins met AS01 hulpstof (gordelroos, RSV) gekoppeld aan minder dementie. Het immuunsysteem vecht misschien tegen meer dan alleen infecties. www.nature.com/articles/s41...
Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk www.news-medical.net/news/2025063... #dementia #vaccines #AS01 #prevention #neurology #aging #publichealth #innovation #brainhealth #shingrix
Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk
Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The...
www.news-medical.net
July 1, 2025 at 12:11 AM
Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk www.news-medical.net/news/2025063... #dementia #vaccines #AS01 #prevention #neurology #aging #publichealth #innovation #brainhealth #shingrix