Abacavir and tenofovir in the same ART regimen
IYKYK
IYKYK
The menswear guy, but for antimicrobial regimens
November 27, 2024 at 2:23 AM
Abacavir and tenofovir in the same ART regimen
IYKYK
IYKYK
Cardiovascular hazards of Abacavir- vs. Tenofovir-containing antiretroviral therapies: Insights from an analysis of the REPRIEVE trial cohort
#IDSky
#HIV
academic.oup.com/ofid/advance...
#IDSky
#HIV
academic.oup.com/ofid/advance...
Cardiovascular hazards of abacavir- versus tenofovir-containing antiretroviral therapies: Insights from an analysis of the REPRIEVE trial cohort
Time-updated analyses of the REPRIEVE trial cohort suggest antiretroviral therapies featuring abacavir (ABC) backbones increase the hazard of major adverse
academic.oup.com
March 30, 2025 at 1:46 PM
Cardiovascular hazards of Abacavir- vs. Tenofovir-containing antiretroviral therapies: Insights from an analysis of the REPRIEVE trial cohort
#IDSky
#HIV
academic.oup.com/ofid/advance...
#IDSky
#HIV
academic.oup.com/ofid/advance...
#IDsky
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
March 21, 2025 at 12:18 PM
#IDsky
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
October 22, 2025 at 6:02 PM
Introduce yourself as what almost killed you
Hi, I’m the rogue waves that dragged me into the Mid Atlantic, I’m the bacterial endocarditis, sepsis & kidney failure that arrived after a Baltic cruise, I’m the severe allergic reaction to Abacavir that crashed my blood pressure. Pleased to meet you!
Hi, I’m the rogue waves that dragged me into the Mid Atlantic, I’m the bacterial endocarditis, sepsis & kidney failure that arrived after a Baltic cruise, I’m the severe allergic reaction to Abacavir that crashed my blood pressure. Pleased to meet you!
Introduce yourself as what almost killed you:
Hello, I’m the unseen tram, the drunk driver, the concrete on the other side of the wall, the arrow, the electric shock, the severe illness, the black ice, the psychotic ex, and middle aged ennui.
Hello, I’m the unseen tram, the drunk driver, the concrete on the other side of the wall, the arrow, the electric shock, the severe illness, the black ice, the psychotic ex, and middle aged ennui.
Introduce yourself as what almost killed you:
Hello, I’m streptococcus bacteria sitting on your previously undiagnosed bicuspid aortic heart valves. Planning on doing any breathing.
And I’m still the reason you’re sitting in a hospital right now.
Hello, I’m streptococcus bacteria sitting on your previously undiagnosed bicuspid aortic heart valves. Planning on doing any breathing.
And I’m still the reason you’re sitting in a hospital right now.
January 2, 2026 at 5:35 PM
Introduce yourself as what almost killed you
Hi, I’m the rogue waves that dragged me into the Mid Atlantic, I’m the bacterial endocarditis, sepsis & kidney failure that arrived after a Baltic cruise, I’m the severe allergic reaction to Abacavir that crashed my blood pressure. Pleased to meet you!
Hi, I’m the rogue waves that dragged me into the Mid Atlantic, I’m the bacterial endocarditis, sepsis & kidney failure that arrived after a Baltic cruise, I’m the severe allergic reaction to Abacavir that crashed my blood pressure. Pleased to meet you!
Does ART matter with relation to CVD? Yes.
Abacavir is bad for people experiencing or at risk for CVD.
#HIVGlasgow2024
Abacavir is bad for people experiencing or at risk for CVD.
#HIVGlasgow2024
November 10, 2024 at 11:03 AM
Does ART matter with relation to CVD? Yes.
Abacavir is bad for people experiencing or at risk for CVD.
#HIVGlasgow2024
Abacavir is bad for people experiencing or at risk for CVD.
#HIVGlasgow2024
So EACS has followed DHHS and relegated abacavir to 'alternative' 1st line status. Time for @bhiva.bsky.social to do the same? If you look at consultation comments @tristanjbarber.bsky.social called for this last time round.
BHIVa had already relegated raltegravir mind.
#hivglasgow #hivglasgow2024
BHIVa had already relegated raltegravir mind.
#hivglasgow #hivglasgow2024
November 13, 2024 at 8:55 AM
So EACS has followed DHHS and relegated abacavir to 'alternative' 1st line status. Time for @bhiva.bsky.social to do the same? If you look at consultation comments @tristanjbarber.bsky.social called for this last time round.
BHIVa had already relegated raltegravir mind.
#hivglasgow #hivglasgow2024
BHIVa had already relegated raltegravir mind.
#hivglasgow #hivglasgow2024
An open label 🇩🇰 RCT comparing weight changes associated with DTG/ABC/3TC vs. DTG/3TC in virally suppressed pts at one year.
Result: No difference.
bmcinfectdis.biomedcentral.com/articles/10....
#IDSky
Result: No difference.
bmcinfectdis.biomedcentral.com/articles/10....
#IDSky
No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologica...
Background Antiretroviral therapy (ART) in people with HIV (PWH) can lead to weight gain, but the effects of nucleoside reverse transcriptase inhibitors such as abacavir (ABC) are not well understood....
bmcinfectdis.biomedcentral.com
September 4, 2025 at 1:52 AM
An open label 🇩🇰 RCT comparing weight changes associated with DTG/ABC/3TC vs. DTG/3TC in virally suppressed pts at one year.
Result: No difference.
bmcinfectdis.biomedcentral.com/articles/10....
#IDSky
Result: No difference.
bmcinfectdis.biomedcentral.com/articles/10....
#IDSky
Many honourable mentions too many to mention! Didn't make the list because technically an antiviral, but abacavir HLA-B*57:01 changed the face of preventive medicine in #ID #HIV forever...
www.nejm.org/doi/10.1056/...
www.nejm.org/doi/10.1056/...
HLA-B*5701 Screening for Hypersensitivity to Abacavir | NEJM
Hypersensitivity reaction to abacavir is strongly associated with the presence of
the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective
HLA-B*5701 screening t...
www.nejm.org
November 12, 2024 at 8:00 AM
Many honourable mentions too many to mention! Didn't make the list because technically an antiviral, but abacavir HLA-B*57:01 changed the face of preventive medicine in #ID #HIV forever...
www.nejm.org/doi/10.1056/...
www.nejm.org/doi/10.1056/...
Is there any reason to check HLA-B5701 or any reason to start someone on abacavir in 2025? We will need a new random ART factoid to quiz people on if this practice goes away.
January 6, 2025 at 2:19 PM
Is there any reason to check HLA-B5701 or any reason to start someone on abacavir in 2025? We will need a new random ART factoid to quiz people on if this practice goes away.
🩺💊 New REPRIEVE data confirm abacavir use increases MACE risk in adults with HIV. In the modern ART era, we should critically rethink abacavir’s role in HIV treatment to align with CV risk reduction goals.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Global “expiration” of abacavir in adults with HIV: a rapid review of safety and efficacy concerns challenging its role in modern ART - David B. Cluck, Daniel B. Chastain, Jacob D. Lines, William R. S...
Emerging evidence from the REPRIEVE study cohort has further clarified the association between abacavir use and cardiovascular risk. This analysis, along with p...
journals.sagepub.com
July 9, 2025 at 2:44 PM
🩺💊 New REPRIEVE data confirm abacavir use increases MACE risk in adults with HIV. In the modern ART era, we should critically rethink abacavir’s role in HIV treatment to align with CV risk reduction goals.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Dolutegravir/abacavir/lamivudine in acute HIV-1 results in rapid suppression and restoration of CD4 T cell subsets without accelerated decay of latent HIV
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Dolutegravir/abacavir/lamivudine in acute HIV-1 results in rapid suppression and restoration of CD4 T cell subsets without accelerated decay of latent HIV
We evaluated rapid start of integrase-based antiretroviral therapy (ART) during acute HIV-1.
doi.org
May 1, 2025 at 2:33 PM
Dolutegravir/abacavir/lamivudine in acute HIV-1 results in rapid suppression and restoration of CD4 T cell subsets without accelerated decay of latent HIV
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Looks like a few drugs have moved up from supplementary concept to full #2026MeSH descriptor:
Semaglutide
www.ncbi.nlm.nih.gov/mesh/D000099...
Abacavir (I think this was supp con before?)
www.ncbi.nlm.nih.gov/mesh/D000099...
Semaglutide
www.ncbi.nlm.nih.gov/mesh/D000099...
Abacavir (I think this was supp con before?)
www.ncbi.nlm.nih.gov/mesh/D000099...
January 21, 2026 at 7:02 PM
Looks like a few drugs have moved up from supplementary concept to full #2026MeSH descriptor:
Semaglutide
www.ncbi.nlm.nih.gov/mesh/D000099...
Abacavir (I think this was supp con before?)
www.ncbi.nlm.nih.gov/mesh/D000099...
Semaglutide
www.ncbi.nlm.nih.gov/mesh/D000099...
Abacavir (I think this was supp con before?)
www.ncbi.nlm.nih.gov/mesh/D000099...
I have one on Abacavir. Finally went rogue from my training and no longer getting HLAB5701 screening on intake because there are multiple other kidney sparing options that I’d use first.
March 21, 2025 at 2:08 PM
I have one on Abacavir. Finally went rogue from my training and no longer getting HLAB5701 screening on intake because there are multiple other kidney sparing options that I’d use first.
He's on abacavir, lamivudine, and raltegravir but noted, will continue
December 27, 2024 at 4:37 AM
He's on abacavir, lamivudine, and raltegravir but noted, will continue
Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis www.thelancet.com/journals/lan... (subscription req for full text)
Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis
Previous and current use of abacavir increases the hazard of MACE among people with
HIV at low-to-moderate CVD risk, suggesting that abacavir should be avoided and previous
exposure considered when as...
www.thelancet.com
June 9, 2025 at 3:25 PM
Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis www.thelancet.com/journals/lan... (subscription req for full text)
I’m afraid they have an M184V mutation that would make the Abacavir and Lamivudine ineffective (VF=virologic failure).
In general I try to avoid Abacavir because of the cardiovascular effects. This pt was on it when they came to me.
In general I try to avoid Abacavir because of the cardiovascular effects. This pt was on it when they came to me.
January 16, 2025 at 6:36 PM
I’m afraid they have an M184V mutation that would make the Abacavir and Lamivudine ineffective (VF=virologic failure).
In general I try to avoid Abacavir because of the cardiovascular effects. This pt was on it when they came to me.
In general I try to avoid Abacavir because of the cardiovascular effects. This pt was on it when they came to me.
Risk for major adverse cardiovascular events (MACE) among individuals with HIV infection higher in those receiving abacavir- vs tenofovir-based antiretroviral therapy (ART). (Study) #IDSky #HIV
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
Cardiovascular Hazards of Abacavir- Versus Tenofovir-Containing Antiretroviral Therapies: Insights From an Analysis of the REPRIEVE Trial Cohort
Time-updated analyses of the REPRIEVE cohort suggest that antiretroviral therapies featuring abacavir backbones increase hazard of major adverse cardiovasc
academic.oup.com
June 10, 2025 at 12:49 PM
Risk for major adverse cardiovascular events (MACE) among individuals with HIV infection higher in those receiving abacavir- vs tenofovir-based antiretroviral therapy (ART). (Study) #IDSky #HIV
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
Jornada: "Colectivos de personas con VIH denuncian escasez de medicamentos antirretrovirales en hospitales del Minsa y EsSalud, con faltantes de dolutegravir, efavirenz, abacavir y más. 36,360 tabletas de Abacavir y 25,380 tabletas de Dolutegravir sin abastecimiento. Los pacientes padecen y muere...
Colectivos denuncian escasez de antirretrovirales en hospitales del Minsa y EsSalud
"Colectivos de personas con VIH denuncian escasez de medicamentos antirretrovirales en hospitales del Minsa y EsSalud, con faltantes de dolutegravir, efavirenz, abacavir y más. 36,360 tabletas de Abacavir y 25,380 tabletas de Dolutegravir sin abastecimiento. Los pacientes padecen y mueren por la falta de atención médica asegurada."
jornada.com.pe
July 24, 2025 at 8:00 PM
Jornada: "Colectivos de personas con VIH denuncian escasez de medicamentos antirretrovirales en hospitales del Minsa y EsSalud, con faltantes de dolutegravir, efavirenz, abacavir y más. 36,360 tabletas de Abacavir y 25,380 tabletas de Dolutegravir sin abastecimiento. Los pacientes padecen y muere...
Technically that's your immune system flaying you alive, because abacavir or something apparently pisses it off so much it decides to kill you slowly.
December 31, 2025 at 1:21 AM
Technically that's your immune system flaying you alive, because abacavir or something apparently pisses it off so much it decides to kill you slowly.
HIV Combination Drug Therapies: Development and Validation of an LC-MS/MS Method for Simultaneous Quantitation of Abacavir, Dolutegravir, and Lamivudine in Rat Matrices in Support of Toxicology Studies #JAT academic.oup.com/jat/advance-...
HIV Combination Drug Therapies: Development and Validation of an LC-MS/MS Method for Simultaneous Quantitation of Abacavir, Dolutegravir, and Lamivudine in Rat Matrices in Support of Toxicology Studie...
Abstract. Abacavir (ABC), Dolutegravir (DTG), and Lamivudine (3TC) are part of a fixed-dose combination medication for treatment of HIV. The three drugs of
academic.oup.com
March 1, 2025 at 7:37 AM
HIV Combination Drug Therapies: Development and Validation of an LC-MS/MS Method for Simultaneous Quantitation of Abacavir, Dolutegravir, and Lamivudine in Rat Matrices in Support of Toxicology Studies #JAT academic.oup.com/jat/advance-...
I think this is one of the few times I made a big clinical change based on the press release.
Since this came out in June, I have been much more aggressive getting ppl off ABC/DTG/3TC. Generally have been switching to DTG/3TC.
www.nih.gov/news-events/...
Since this came out in June, I have been much more aggressive getting ppl off ABC/DTG/3TC. Generally have been switching to DTG/3TC.
www.nih.gov/news-events/...
Exploratory analysis associates HIV drug abacavir with elevated cardiovascular disease risk in large global trial
Findings add to body of evidence on cardiovascular risk factors for people with HIV.
www.nih.gov
March 22, 2025 at 12:46 AM
I think this is one of the few times I made a big clinical change based on the press release.
Since this came out in June, I have been much more aggressive getting ppl off ABC/DTG/3TC. Generally have been switching to DTG/3TC.
www.nih.gov/news-events/...
Since this came out in June, I have been much more aggressive getting ppl off ABC/DTG/3TC. Generally have been switching to DTG/3TC.
www.nih.gov/news-events/...
The use of nucleoside reverse transcriptase inhibitors, but not other HIV medicines, is linked to a reduced risk for Alzheimer’s disease, new research shows. http://ms.spr.ly/63322Sb16I
May 18, 2025 at 1:00 PM
The use of nucleoside reverse transcriptase inhibitors, but not other HIV medicines, is linked to a reduced risk for Alzheimer’s disease, new research shows. http://ms.spr.ly/63322Sb16I
Study finds dolutegravir/abacavir/lamivudine HIV therapy linked to increases in BMI, BP, and cholesterol compared to efavirenz-based regimen over 96 weeks. Both achieved high viral suppression rates. Clinicians should monitor cardiovascular risk factors. #HIV #HIVTreatment
Popular HIV Therapy Linked to Higher BMI and Cholesterol
Patients with acute HIV infection who initiate dolutegravir/abacavir/lamivudine therapy have greater increases in BMI, systolic blood pressure, and lipid parameters, a retrospective study shows.
buff.ly
August 29, 2025 at 7:03 PM
Study finds dolutegravir/abacavir/lamivudine HIV therapy linked to increases in BMI, BP, and cholesterol compared to efavirenz-based regimen over 96 weeks. Both achieved high viral suppression rates. Clinicians should monitor cardiovascular risk factors. #HIV #HIVTreatment
Yes this image is from crystal structure PDB:3UPR in which abacavir-modified peptide was loaded on MHCI. There are not many examples with structures available but there are review articles about this phenomenon.
August 11, 2026 at 12:44 PM
Yes this image is from crystal structure PDB:3UPR in which abacavir-modified peptide was loaded on MHCI. There are not many examples with structures available but there are review articles about this phenomenon.