#AdvSci
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Integrating Spatial Proteogenomics in Cancer Research #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
Integrating Spatial Proteogenomics in Cancer Research
Xx xx.
advanced.onlinelibrary.wiley.com
February 13, 2026 at 8:24 PM
realbiomassspec.bsky.social
From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models
A comprehensive technology platform enables high-fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi-automated computational framework for 3D reconstr...
advanced.onlinelibrary.wiley.com
December 17, 2025 at 7:53 PM
realbiomassspec.bsky.social
Microdroplet Stabilization Enabled Direct Mass Spectrometric Identification of Electrogenerated Transient Carbocation Intermediates #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
Microdroplet Stabilization Enabled Direct Mass Spectrometric Identification of Electrogenerated Transient Carbocation Intermediates
The in situ mass spectrometric identification of the electrogenerated benzylic and phenylic carbocations, whose half-lives in bulk solutions are on the nanosecond scale, is achieved by taking advanta...
advanced.onlinelibrary.wiley.com
December 8, 2025 at 8:29 PM
realbiomassspec.bsky.social
Image Fusion for Super‐Resolution Mass Spectrometry Imaging of Plant Tissue #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
November 19, 2025 at 8:53 PM
realbiomassspec.bsky.social
Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
November 18, 2025 at 7:46 PM
realbiomassspec.bsky.social
Toward a Species Search Engine: KISSE Offers a Rigorous Statistical Framework for Bone Collagen Tandem Mass Spectrometry Data #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
Toward a Species Search Engine: KISSE Offers a Rigorous Statistical Framework for Bone Collagen Tandem Mass Spectrometry Data
The Species Search Engine (KISSE) is a novel statistical approach for identifying species from collagen peptides, using a curated library of sequences and their relative abundances derived from shotg...
advanced.onlinelibrary.wiley.com
August 12, 2025 at 6:00 AM
realbiomassspec.bsky.social
Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
August 5, 2025 at 7:30 AM
realbiomassspec.bsky.social
A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
August 5, 2025 at 7:29 AM
realbiomassspec.bsky.social
Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high-throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degenera....
advanced.onlinelibrary.wiley.com
July 26, 2025 at 4:34 AM
realbiomassspec.bsky.social
DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training #AdvSci #MassSpec ps://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202504109
DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training
DeepSecMS, a deep learning platform leveraging a Cys-to-Sec proxy training strategy, enhances the identification of known selenoproteins and holds promise for discovering novel candidates. This proxy....
advanced.onlinelibrary.wiley.com
July 23, 2025 at 4:50 AM
realbiomassspec.bsky.social
Prediction of Lung Cancer Metastasis Risk Based on Single‐Cell Metabolic Profiling of Circulating Tumor Cells #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
Prediction of Lung Cancer Metastasis Risk Based on Single‐Cell Metabolic Profiling of Circulating Tumor Cells
A self-developed CTC sorting and capture platform enabled single-cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis-specific metabolic signatures. A classification model develo...
advanced.onlinelibrary.wiley.com
July 21, 2025 at 2:58 PM
realbiomassspec.bsky.social
Unraveling Tissue-Specific Fatty Acid Biosynthesis and Inter-Tissue Crosstalk in Mice through Stable-Isotope Tracing Metabolomics #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter-tissue communications of fatty acids between the l...
advanced.onlinelibrary.wiley.com
May 30, 2025 at 6:57 PM
realbiomassspec.bsky.social
Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring
This study presents a fully automated miniature mass spectrometry system for high-throughput therapeutic drug monitoring. Integrating magnetic solid-phase extraction, self-aspiration sampling miniatu...
advanced.onlinelibrary.wiley.com
May 23, 2025 at 7:12 PM
realbiomassspec.bsky.social
High-Throughput Proteoform Imaging for Revealing Spatial-Resolved Changes in Brain Tissues Associated with Alzheimer's Disease #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease
High-throughput proteoform imaging (HTPi) is established by combining matrix-assisted laser desorption ionization mass spectrometry imaging and high-sensitivity region-specific top-down proteomic ana...
advanced.onlinelibrary.wiley.com
March 12, 2025 at 7:37 PM
realbiomassspec.bsky.social
Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity
Rheumatoid arthritis is a prototypic autoimmune disease characterized by highly prevalent autoantibodies – anti-citrullinated protein antibodies (ACPA). A novel nanoHPLC-MS approach based on the inta...
advanced.onlinelibrary.wiley.com
February 23, 2025 at 8:56 AM
realbiomassspec.bsky.social
One-Pot Construction of NHS-Activated Magnetic Particles for Chemoselective Capture of Carboxyl Metabolites #AdvSci #MassSpec advanced.onlinelibrary.wiley.com/doi/10.1002/...
One‐Pot Construction of NHS‐Activated Magnetic Particles for Chemoselective Capture of Carboxyl Metabolites
A novel strategy for the one-pot synthesis of NHS-activated magnetic particles from isocyanates is proposed. These synthesized magnetic particles function as effective immobilization carriers for che...
advanced.onlinelibrary.wiley.com
February 11, 2025 at 8:36 PM
realbiomassspec.bsky.social
Characterization of the Micro-Morphology and Compositional Distribution of Chang'e-5 Lunar Soil Mineral Surfaces Using TOF-SIMS #AdvSci advanced.onlinelibrary.wiley.com/doi/10.1002/...
Characterization of the Micro‐Morphology and Compositional Distribution of Chang'e‐5 Lunar Soil Mineral Surfaces Using TOF‐SIMS
Lunar soil samples from Chang'e 5 are characterized by high-resolution time-of-flight secondary ion mass spectrometry, which revealed uncommon vesicle patterns that may not be observed via the conven...
advanced.onlinelibrary.wiley.com
January 22, 2025 at 6:55 PM
realbiomassspec.bsky.social
Unraveling Spatial Heterogeneity in Mass Spectrometry Imaging Data with GraphMSI #AdvSci #MassSpec onlinelibrary.wiley.com/doi/10.1002/...
Unraveling Spatial Heterogeneity in Mass Spectrometry Imaging Data with GraphMSI
Mass spectrometry imaging (MSI) provides valuable insights into metabolic heterogeneity within biosamples. GraphMSI is proposed, a deep learning-based method that integrates metabolic profiles with s...
onlinelibrary.wiley.com
January 9, 2025 at 9:02 PM
realbiomassspec.bsky.social
Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning #AdvSci #MassSpec onlinelibrary.wiley.com/doi/10.1002/...
Non‐Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning
Moyamoya disease (MMD) increases stroke risk, but current invasive diagnostic methods are costly. To address this, nanoparticle-enhanced laser desorption/ionization mass spectrometry was used to anal...
onlinelibrary.wiley.com
December 31, 2024 at 7:09 PM
realbiomassspec.bsky.social
Mass-Guided Single-Cell MALDI Imaging of Low-Mass Metabolites Reveals Cellular Activation Markers #AdvSci onlinelibrary.wiley.com/doi/10.1002/...
Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers
The PRISM-MS workflow transforms single-cell mass spectrometry imaging by allowing detailed analysis of low-mass metabolites in large cell populations without metabolite degradation. By introducing n...
onlinelibrary.wiley.com
December 12, 2024 at 1:09 PM
margaretmorgan.bsky.social
Very good to hear, Belinda! That's the AdvSci degree I did at Macquarie, I think? I loved it. Glad it's still running.
December 13, 2025 at 12:28 AM
haoyin.bsky.social
Inhaled ANGPTL4 antisense oligonucleotide for 🐭Acute Lung Injury
1⃣Bacteria: P.aeruginosa
2⃣Virus: Influenza PR8
3⃣Bleomycin

⏬🫁inflammation, preserving partial IFN response
⏬FGF signal, Fibrosis
⏫Epithelial glycoprotein (#MassSpecImaging)

#AdvSci 2026
advanced.onlinelibrary.wiley.com/doi/10.1002/...
April 13, 2026 at 12:35 PM
haoyin.bsky.social
Multi-Region Vascularized Brain Organoids
Integration of hiPSC-derived cerebral, mid/hindbrain & endothelial organoids

scRNAseq▶️"13 (!?🧐) previously uncharacterized endothelial-neural signaling interactions"

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
March 4, 2026 at 1:07 PM
haoyin.bsky.social
#Exosome from hTERT- #MesenchymalStemCell overexpressing PD-L1 + HGF i.v. Immediately following🐭Stroke
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
January 28, 2026 at 12:55 PM
haoyin.bsky.social
Spatial Multiomics▶️ aberrant activation of Polyamine Metabolism in Oral Submucous Fibrosis-derived Oral Squamous Cell Carcinoma

#SpatialTranscriptomics Visium
#SpatialMetabolomics #MassSpecImaging

High polyamine➡️⏬OSCC survival

#AdvSci 2024
advanced.onlinelibrary.wiley.com/doi/10.1002/...
January 20, 2026 at 10:29 PM