"This cover depicts The Bridge in the NGS Rain where people are being exposed to torrents of genomic information [...]. The man standing in the middle of the bridge is pictured deep in thought, considering how to utilize this sequence data set of the ALDH2 gene." @mbsj-official.bsky.social
February 4, 2026 at 7:05 PM
"This cover depicts The Bridge in the NGS Rain where people are being exposed to torrents of genomic information [...]. The man standing in the middle of the bridge is pictured deep in thought, considering how to utilize this sequence data set of the ALDH2 gene." @mbsj-official.bsky.social
I think I mentioned it here before but I seem to be lacking ALDH2 so cannot break down alcohol.
March 27, 2026 at 12:46 PM
I think I mentioned it here before but I seem to be lacking ALDH2 so cannot break down alcohol.
www.popsci.com/science/is-a...
Genetics is important! Carriers of a variant in the alcohol metabolism pathway known as ALDH2*2 causes an accumulation of acetaldehyde which is a known carcinogen. Risk of cancer is higher for carriers of this variant. #dryjanuary #alcohol #Aldh2
Genetics is important! Carriers of a variant in the alcohol metabolism pathway known as ALDH2*2 causes an accumulation of acetaldehyde which is a known carcinogen. Risk of cancer is higher for carriers of this variant. #dryjanuary #alcohol #Aldh2
www.popsci.com
January 14, 2025 at 1:20 AM
www.popsci.com/science/is-a...
Genetics is important! Carriers of a variant in the alcohol metabolism pathway known as ALDH2*2 causes an accumulation of acetaldehyde which is a known carcinogen. Risk of cancer is higher for carriers of this variant. #dryjanuary #alcohol #Aldh2
Genetics is important! Carriers of a variant in the alcohol metabolism pathway known as ALDH2*2 causes an accumulation of acetaldehyde which is a known carcinogen. Risk of cancer is higher for carriers of this variant. #dryjanuary #alcohol #Aldh2
私の肝臓のアセトアルデヒド分解酵素ALDH2が頑張ってくれる
May 10, 2025 at 1:23 PM
私の肝臓のアセトアルデヒド分解酵素ALDH2が頑張ってくれる
please note that the normative calculations and studies i used were based on assessments from western european caucasian populations. many asian populations have a mutation of the alcoholdehydragenase (ALDH2*2) which reduces the activity of this enzyme in the elimination process.
June 19, 2025 at 7:21 PM
please note that the normative calculations and studies i used were based on assessments from western european caucasian populations. many asian populations have a mutation of the alcoholdehydragenase (ALDH2*2) which reduces the activity of this enzyme in the elimination process.
Alcohol intolerance, also called ALDH2 deficiency, is a genetic condition that makes it hard for some people to break down a chemical from alcohol called acetaldehyde.
⚠️Build up of acetaldehyde could lead to long-term health risks!!!
#ALDH2#AlcoholIntolerance
@ericgross.bsky.social
⚠️Build up of acetaldehyde could lead to long-term health risks!!!
#ALDH2#AlcoholIntolerance
@ericgross.bsky.social
July 1, 2025 at 3:16 AM
Alcohol intolerance, also called ALDH2 deficiency, is a genetic condition that makes it hard for some people to break down a chemical from alcohol called acetaldehyde.
⚠️Build up of acetaldehyde could lead to long-term health risks!!!
#ALDH2#AlcoholIntolerance
@ericgross.bsky.social
⚠️Build up of acetaldehyde could lead to long-term health risks!!!
#ALDH2#AlcoholIntolerance
@ericgross.bsky.social
Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
June 10, 2025 at 9:00 AM
Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
As part of #dryjanuary ,
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
January 11, 2025 at 11:46 PM
As part of #dryjanuary ,
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
A new Substack post on a recent paper in Science Advances that reports interesting GxG interactions for the East-Asian specific ALDH2 variant rs671.
www.gwasstories.com/p/a-gene-x-g...
www.gwasstories.com/p/a-gene-x-g...
A gene x gene interaction study of alcohol behavior in East Asians
Regions in the human genome that interact with rs671, a missense variant in ALDH2, and influence alcohol behavior and cancer risk in East Asians.
www.gwasstories.com
January 28, 2024 at 12:58 AM
A new Substack post on a recent paper in Science Advances that reports interesting GxG interactions for the East-Asian specific ALDH2 variant rs671.
www.gwasstories.com/p/a-gene-x-g...
www.gwasstories.com/p/a-gene-x-g...
Aldehydes cause pain in animal models. This suggests that ALDH2 may contribute to regulating nociception. Building on this,we found an ALDH2 activator,Alda-1 that may represent a new drug class to reduce pain. Check out the paper making the cover of STM:surl.li/msilon
@ericgross.bsky.social
@ericgross.bsky.social
August 9, 2025 at 12:00 AM
Aldehydes cause pain in animal models. This suggests that ALDH2 may contribute to regulating nociception. Building on this,we found an ALDH2 activator,Alda-1 that may represent a new drug class to reduce pain. Check out the paper making the cover of STM:surl.li/msilon
@ericgross.bsky.social
@ericgross.bsky.social
For those of us who have been suffering with red wine headaches for years and years, this study offers potential validation.
We all knew it wasn’t the sulfites!
Now I just need a study confirming that Merlot grapes are absolutely laced with quercetin glucuronide…
www.nature.com/articles/s41...
We all knew it wasn’t the sulfites!
Now I just need a study confirming that Merlot grapes are absolutely laced with quercetin glucuronide…
www.nature.com/articles/s41...
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches - Scientific Reports
Scientific Reports - Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches
www.nature.com
November 26, 2024 at 2:41 AM
For those of us who have been suffering with red wine headaches for years and years, this study offers potential validation.
We all knew it wasn’t the sulfites!
Now I just need a study confirming that Merlot grapes are absolutely laced with quercetin glucuronide…
www.nature.com/articles/s41...
We all knew it wasn’t the sulfites!
Now I just need a study confirming that Merlot grapes are absolutely laced with quercetin glucuronide…
www.nature.com/articles/s41...
Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan doi.org/10.1111/acer...
December 16, 2025 at 4:14 PM
Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan doi.org/10.1111/acer...
大学で遺伝子調べたらALDH2がMMで終わりだぁってなりました
May 4, 2025 at 12:33 PM
大学で遺伝子調べたらALDH2がMMで終わりだぁってなりました
ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells https://www.biorxiv.org/content/10.64898/2026.09.21.753265v1
September 22, 2026 at 9:30 PM
ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells https://www.biorxiv.org/content/10.64898/2026.09.21.753265v1
ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells https://www.biorxiv.org/content/10.64898/2026.09.21.753265v1
September 22, 2026 at 9:30 PM
ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells https://www.biorxiv.org/content/10.64898/2026.09.21.753265v1
Some people get dizzy after half a beer, others drink all night, genetics explains a lot.
A gene called CHRNA3 shapes brain signals to stop drinking, while ALDH2 affects liver breakdown speed.
Genetics drives roughly half the risk for alcohol use disorder.
#TheLolgic #Genetics #AlcoholTolerance
A gene called CHRNA3 shapes brain signals to stop drinking, while ALDH2 affects liver breakdown speed.
Genetics drives roughly half the risk for alcohol use disorder.
#TheLolgic #Genetics #AlcoholTolerance
September 25, 2026 at 12:15 AM
Some people get dizzy after half a beer, others drink all night, genetics explains a lot.
A gene called CHRNA3 shapes brain signals to stop drinking, while ALDH2 affects liver breakdown speed.
Genetics drives roughly half the risk for alcohol use disorder.
#TheLolgic #Genetics #AlcoholTolerance
A gene called CHRNA3 shapes brain signals to stop drinking, while ALDH2 affects liver breakdown speed.
Genetics drives roughly half the risk for alcohol use disorder.
#TheLolgic #Genetics #AlcoholTolerance
基本的にALDH2が高活発の方が大酒飲みリスクが高いです！！！そしてお酒強いです！！！
ADH1Bが体に悪い(酔ってる時の気持ち悪さ)を物質を作る働きがありましてALDH2がその物質を無害にしてくれるので！
ADH1Bが体に悪い(酔ってる時の気持ち悪さ)を物質を作る働きがありましてALDH2がその物質を無害にしてくれるので！
October 1, 2025 at 9:31 AM
基本的にALDH2が高活発の方が大酒飲みリスクが高いです！！！そしてお酒強いです！！！
ADH1Bが体に悪い(酔ってる時の気持ち悪さ)を物質を作る働きがありましてALDH2がその物質を無害にしてくれるので！
ADH1Bが体に悪い(酔ってる時の気持ち悪さ)を物質を作る働きがありましてALDH2がその物質を無害にしてくれるので！
New publication alert 📢
This new review explores how alcohol, genetics, aging, immunity, and the gut microbiome converge to shape disease risk across the lifespan.
Read the research: 🔗 zurl.co/AIrI4
#AlcoholResearch #GutMicrobiome #BrainHealth #IntegrativeHealth #ALDH2 #PublicHealth
This new review explores how alcohol, genetics, aging, immunity, and the gut microbiome converge to shape disease risk across the lifespan.
Read the research: 🔗 zurl.co/AIrI4
#AlcoholResearch #GutMicrobiome #BrainHealth #IntegrativeHealth #ALDH2 #PublicHealth
December 10, 2025 at 10:00 PM
New publication alert 📢
This new review explores how alcohol, genetics, aging, immunity, and the gut microbiome converge to shape disease risk across the lifespan.
Read the research: 🔗 zurl.co/AIrI4
#AlcoholResearch #GutMicrobiome #BrainHealth #IntegrativeHealth #ALDH2 #PublicHealth
This new review explores how alcohol, genetics, aging, immunity, and the gut microbiome converge to shape disease risk across the lifespan.
Read the research: 🔗 zurl.co/AIrI4
#AlcoholResearch #GutMicrobiome #BrainHealth #IntegrativeHealth #ALDH2 #PublicHealth
1 in 10 women are affected by endometriosis in their life.
This week, we’re talking about Gross lab research endometriosis and endometriosis-associated pain.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
This week, we’re talking about Gross lab research endometriosis and endometriosis-associated pain.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
July 29, 2025 at 12:00 AM
1 in 10 women are affected by endometriosis in their life.
This week, we’re talking about Gross lab research endometriosis and endometriosis-associated pain.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
This week, we’re talking about Gross lab research endometriosis and endometriosis-associated pain.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
録画していた放送大学の「人文地理学からみる世界」最終回だけ観てる。
予想通り、文化地理学の話題だ。「蝸牛考」やってた。いまはALDH2活性型いで遺伝子の話題だ。
予想通り、文化地理学の話題だ。「蝸牛考」やってた。いまはALDH2活性型いで遺伝子の話題だ。
March 28, 2024 at 1:37 AM
録画していた放送大学の「人文地理学からみる世界」最終回だけ観てる。
予想通り、文化地理学の話題だ。「蝸牛考」やってた。いまはALDH2活性型いで遺伝子の話題だ。
予想通り、文化地理学の話題だ。「蝸牛考」やってた。いまはALDH2活性型いで遺伝子の話題だ。
ALDH2 deficiency causing uticaria? Oof
June 9, 2025 at 1:45 PM
ALDH2 deficiency causing uticaria? Oof
Accumulation of reactive aldehydes is key in endometriosis pathophysiology. Building on this, we determined that increasing ALDH2 activity with the enzyme activator Alda-1 could prevent endometriosis lesion development and alleviate pain-associated behavior using rodent models. shorturl.at/GxiOX
August 10, 2025 at 12:00 AM
Accumulation of reactive aldehydes is key in endometriosis pathophysiology. Building on this, we determined that increasing ALDH2 activity with the enzyme activator Alda-1 could prevent endometriosis lesion development and alleviate pain-associated behavior using rodent models. shorturl.at/GxiOX
Despite affecting ~176 million women worldwide, endometriosis screening, detection, and treatment has made little progress.
Many available treatments cause unwanted side effects and are at times ineffective.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
Many available treatments cause unwanted side effects and are at times ineffective.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
July 30, 2025 at 12:00 AM
Despite affecting ~176 million women worldwide, endometriosis screening, detection, and treatment has made little progress.
Many available treatments cause unwanted side effects and are at times ineffective.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social
Many available treatments cause unwanted side effects and are at times ineffective.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social