#Ameloblast
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ccmb.usc.edu
Congratulations to the Paine lab on their latest publication in Frontiers in Physiology, which introduces a novel Ambn-IRESCre mouse line for studying gene functions during amelogenesis with greater specificity than previous models. 🧪 #CCMBUSC #USCResearch #Amelogenesis #Science #ScienceSky
Frontiers | A novel Ambn-IRESCre mouse line allows ameloblast-specific Smad4 silencing
IntroductionFor more than two decades, enamel researchers have primarily used the keratin-14-Cre (Krt14-Cre) driver line to study ameloblast-specific molecul...
www.frontiersin.org
June 3, 2026 at 5:33 PM
ijosjournal.bsky.social
Normal #enamel thickness does not guarantee normal enamel quality. In mice, disrupting a cell-binding motif in ameloblastin impaired ameloblast polarity and prism organization. Homozygous mutants also had hypomineralized enamel—revealing how cell–matrix contact shapes enamel architecture.👇
August 25, 2026 at 5:48 AM
facebase.bsky.social
New data: microCT datasets from ameloblast-specific Smad4 knockout and Ambn-IRESCre mice. Using a novel ameloblast-restricted Cre line, these data reveal severe enamel-specific pathology and highlight Ambn-IRESCre as a powerful tool for enamel gene function studies: www.facebase.org/2026/02/11/r...
Mutant sample from the dataset MicroCT analysis of ameloblast specific Smad4 conditional knockout mice
February 13, 2026 at 6:03 PM
rridrobot.bsky.social
RRIDs were included in this in Frontiers in Physiology paper. RRIDs improve reproducibility in scientific research. #reproducibility #OpenScience #BetterScience
Frontiers | A novel Ambn-IRESCre mouse line allows ameloblast-specific Smad4 silencing
IntroductionFor more than two decades, enamel researchers have primarily used the keratin-14-Cre (Krt14-Cre) driver line to study ameloblast-specific molecul...
doi.org
June 24, 2026 at 7:02 AM
rridrobot.bsky.social
RRIDs were included in this in International Journal of Oral Science paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #STMpublishing #methodsmatter
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration - International Journal of Oral Science
Read the full paper: Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
doi.org
March 5, 2026 at 8:00 AM
rridrobot.bsky.social
RRID:AB_2629482 from @thermofishersci.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #STMpublishing #methodsmatter #STMpublishing
Odontogenic ameloblast-associated protein (ODAM)-enriched coating improves adhesion of junctional epithelial cells to composite resin via AKT activation
doi.org
December 18, 2025 at 8:00 AM
genesndiseases.bsky.social
This study demonstrates the multidimensional and pivotal role that #Cdc42 plays in #enamel development and #ToothRepair, using inducible epithelium-specific knockout Cdc42 mice, and underscores its part in #Ameloblast differentiation and enamel matrix formation. #medsky

#OpenAccess: buff.ly/lJePLwg
Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium
April 17, 2025 at 11:30 PM
rridrobot.bsky.social
The authors included RRIDs in their in Calcified Tissue International paper! RRIDs improve reproducibility in scientific research. #BetterScience #reproducibility #methodsmatter
ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of OdaphC41*/C41* Mice - Calcified Tissue International
Defects in Odontogenesis-Associated Phosphoprotein (ODAPH) cause autosomal recessive non-syndromic amelogenesis imperfecta (AI; OMIM #614832). We present a 14-year-old boy with delayed tooth eruption and generalized soft and yellow enamel. The proband’s parents and two siblings were unaffected. Whole exome analyses identified the AI-causing homozygous ODAPH truncation mutation (p.Arg77*) in the proband. Both unaffected parents and one sibling were heterozygous for this change. The other sibling had the reference sequence. To better understand the role of ODAPH in normal amelogenesis and resolve conflicting reports of ODAPH expression and function during postsecretory transition (PST), we performed comprehensive Focused-Ion Beam Scanning Electron Microscopy analyses of continuously growing mandibular incisors from one wild-type and two OdaphC41*/C41* mice. Montages of sagittal sections were constructed using 5000 × images covering the surface enamel, ameloblasts,
doi.org
July 7, 2026 at 7:00 AM
haoyin.bsky.social
#FGF9 Tooth🦷 development

Dental Epithelia-derived FGF9▶️
⏫Mesenchymal FGF3/10▶️
⏫DESC survival & Ameloblast differentiation/enamelization
Another good example of FGF orchestration of developmental epithelia-mesenchyme crosstalk

Stem Cell Res Ther 2024
stemcellres.biomedcentral.com/articles/10....
September 19, 2024 at 8:45 PM
asimresearcher.bsky.social
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration https://pubmed.ncbi.nlm.nih.gov/41765949/
March 2, 2026 at 10:48 AM
jbmrplus.bsky.social
Enamel matrix acidification caused by loss of AMELX phosphorylation disrupts ameloblast pH-regulatory machinery

Ai Thu Bui, DMD/PhD, Lasya Bhogadi, BDS/MS, Henry C Margolis, PhD, Elia Beniash, PhD

Published: 01 June

academic.oup.com/jbmrplus/adv...
Enamel matrix acidification caused by loss of AMELX phosphorylation disrupts ameloblast pH-regulatory machinery
Abstract. Amelogenin (AMELX), the predominant extracellular enamel matrix protein, contains a single phosphorylation site at Serine16 (S16). To investigate
academic.oup.com
June 4, 2026 at 3:28 PM
biorxiv-devbio.bsky.social
Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration https://www.biorxiv.org/content/10.1101/2025.04.03.646929v1
April 5, 2025 at 9:31 PM
biorxivpreprint.bsky.social
Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration https://www.biorxiv.org/content/10.1101/2025.04.03.646929v1
April 5, 2025 at 9:31 PM
genesndiseases.bsky.social
This study reveals that Cdc42 deficiency causes enamel defects by disrupting mitochondrial function and inducing oxidative stress in the dental epithelium, highlighting its critical role in ameloblast differentiation.

#OpenAccess: doi.org/10.1016/j.ge...
March 6, 2026 at 1:30 AM
sciences.skyfleet.blue
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease - Nature
A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.
www.nature.com
November 22, 2023 at 9:46 PM
sciences.skyfleet.blue
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease - Nature
A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.
www.nature.com
November 22, 2023 at 4:27 PM