Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a reduced platelet count, resulting in bleeding risks and compromised quality of life. Advances in understanding ITP pathogene....

We report a green, multicomponent cascade synthesis of 3-aminopyridines via [1,3′-bipyridin]-1-ium intermediates undergoing Zincke aminolysis with ammonia supported by experimental evidence and DFT calculations. The method offers broad scope (>20 examples), good functional group tolerance, and scalability in batch and flow procedures. Synthetic utility is demonstrated through conversion into 3-halo, 3-hydroxy, and 3-thiopyridines, expanding the access to meta-substituted pyridines through peripheral editing of the unprotected amino group.

The development of precursors for hydrogenation processes based on heterometallic iron(III) complexes will provide a relevant alternative to "non-platinum" catalysts. Methods for the synthesis of pivalate...