#Angelman
Colin Farrell has spoken on several occasions about his close relationship with his 23-year-old son James, who was diagnosed with Angelman syndrome as a toddler
Inside Colin Farrell's close bond with son who battles rare neurological disease
www.irishstar.com
November 7, 2026 at 9:34 AM
1/6 📋 $RARE Ultragenyx Pharmaceutical terminated three GTX-102 trials in Angelman Syndrome on the same day, InsiderWatch's biotech tracker flagged.
Read the full story
RARE: Ultragenyx Terminates Angelman Syndrome Program, Completes GSD Study InsiderWatch | insider.wizybit.com
insider.wizybit.com
November 6, 2026 at 2:25 PM
Signal or noise? > Ultragenyx is cutting about 20% of its staff while ending
drug programs for Angelman and Wilson diseases - Medical
Daily >> Comment below! #strategy #competitiveintelligence #marketing #healthcare #competitivemarketing #pharmaceutical #biotech #pharma
Ultragenyx is cutting about 20% of its staff while ending drug programs for Angelman and Wilson diseases - Medical Daily
Ultragenyx is cutting about 20% of its staff while ending drug programs for Angelman and Wilson diseases  Medical Daily
dlvr.it
November 7, 2026 at 1:00 AM
1/4 🧬 $RARE Ultragenyx Pharmaceutical halted three trials targeting Angelman Syndrome, InsiderWatch's biotech tracker reports.

On November 3, the company terminated two Phase 3 studies and one Phase 2 trial for GTX-102, its lead candidate for Angelman Syndrome.
Read the full story
RARE Halts Three Angelman Syndrome Trials, Narrows Pipeline InsiderWatch | insider.wizybit.com
insider.wizybit.com
November 5, 2026 at 2:25 PM
🎉 New paper is out in Nature communications!
We investigated the molecular basis of the HERC2-UBE3A interaction and uncovered a broader protein interaction network that may have important implications for neurodevelopmental disorders, including Angelman syndrome.

www.nature.com/articles/s41...
HERC2–UBE3A structure uncovers a domain-motif protein network potentially altered in Angelman and related syndromes - Nature Communications
UBE3A and HERC2 are two interacting HECT E3 ligases altered in Angelman and related neurodevelopmental syndromes. Here the authors show UBE3A to bind HERC2 via a “DxDKDxD” motif found in nine addition...
www.nature.com
November 3, 2026 at 3:11 PM
Colin Farrell has spoken on several occasions about his close relationship with his 23-year-old son James, who was diagnosed with Angelman syndrome as a toddler
Inside Colin Farrell's close bond with son who battles rare neurological disease
www.irishstar.com
November 5, 2026 at 5:25 PM
5/6 InsiderWatch scores the Angelman program terminations as bearish. Rare-disease developers live or die on their pipeline depth; losing three parallel…
November 6, 2026 at 2:25 PM
4/4 The timing and scope of the Angelman halt signal heavy headwinds for the pipeline's near-term catalysts. Full: https://insider.wizybit.com/blog/post?slug=rare-halts-three-angelman-syndrome-trials-after-gtx-102-setback-2026-11-04
November 4, 2026 at 2:25 PM
November 6, 2026 at 2:25 PM
Colin Farrell, sobre su hijo James y el síndrome de Angelman: “Me enseñó el deseo de vivir” ver.tw/k5tzp6
Colin Farrell, sobre su hijo James y el síndrome de Angelman: “Me enseñó el deseo de vivir”
Colin Farrell ha mantenido durante años su vida familiar lejos de los focos, pero el documenta l 'The Slightest Touch' permitirá conocer una faceta
ver.tw
November 5, 2026 at 11:45 AM
El emotivo vínculo entre Colin Farrell y si hijo James, que padece el síndrome de Angelman: “Me enseñó el deseo de vivir” ver.tw/k5tzp3
Colin Farrell, sobre su hijo James y el síndrome de Angelman: “Me enseñó el deseo de vivir”
Colin Farrell ha mantenido durante años su vida familiar lejos de los focos, pero el documenta l 'The Slightest Touch' permitirá conocer una faceta
ver.tw
November 5, 2026 at 3:56 PM
🔴 #$RARE — Clinical Milestone
GTX-102 Angelman Studies Being Wound Down
As part of restructuring, Ultragenyx is completing the wind-down of all ongoing GTX-102 studies for Angelman syndrome after the Phase 3 Aspire miss.

https://biostock.app/symbols/RARE
November 3, 2026 at 9:30 PM
4/6 Against this, a Phase 3 completion in Glycogen Storage Disease Type IA posted in mid-October—a win for a different asset—but the Angelman Syndrome terminations dominate the recent signal pattern and carry heavier clinical weight.
November 6, 2026 at 2:25 PM
1/4 🔬 $RARE Ultragenyx Pharmaceutical halted two Phase 3 Angelman Syndrome trials this week, a hard reversal after months of development on GTX-102. A Phase 2 study in the same indication also terminated, leaving the program's clinical path in doubt.
Read the full story
RARE Halts Three Angelman Syndrome Trials After GTX-102 Setback InsiderWatch | insider.wizybit.com
insider.wizybit.com
November 4, 2026 at 2:25 PM
4/4 trials at once in a single indication amounts to a sharp downgrade to near-term catalysts. Full: https://insider.wizybit.com/blog/post?slug=rare-halts-three-angelman-syndrome-trials-narrows-pipeline-2026-11-05
November 5, 2026 at 2:25 PM
Colin Farrell új dokumentumfilmjének előzetesében 23 éves fiával, Jamesszel látható. A novemberben érkező alkotás ritka, személyes pillanatot mutat meg az ír színész és Angelman-szindrómával élő fia szeretetteljes kapcsolatából. A jelenetről az NLC számolt be.
Colin Farrell 23 éves, Angelman-szindrómával élő fia is feltűnik
Colin Farrell új dokumentumfilmjének előzetesében 23 éves fiával, Jamesszel látható. A novemberben érkező alkotás ritka, személyes pillanatot mutat meg az ír színész és Angelman-szindrómával élő fia szeretetteljes kapcsolatából. A jelenetről az NLC számolt be.
www.startlap.hu
November 3, 2026 at 1:00 PM
2/4 The three trial stops (announced 2026-11-03) span a safety-and-efficacy study, a long-term extension, and the earlier-stage Phase 2 work—all in deletion- or nondeletion-type Angelman Syndrome under sponsor Ultragenyx.
November 4, 2026 at 2:25 PM
Colin Farrell abbraccia e bacia il figlio con la sindrome di Angelman: ecco le immagini commoventi del documentario “The Slightest Touch” – IL VIDEO
Colin Farrell abbraccia e bacia il figlio con la sindrome di Angelman: ecco le immagini commoventi del documentario "The Slightest Touch" - IL VIDEO - Il Fatto Quotidiano
Colin Farrell apre le porte della sua vita privata nel documentario The Slightest Touch su HBO Max. Le immagini con il figlio James sono toccanti
www.ilfattoquotidiano.it
November 3, 2026 at 9:56 AM
Colin Farrell: Rare appearance of his son James who suffers from Angelman Syndrome

Colin Farrell shares a particularly tender moment with his eldest son, James, in the trailer for new documentary 'The Slightest Touch'. The 50-year-old Irish actor welcomed 23-year-old James with ex-partner Kim…
Colin Farrell: Rare appearance of his son James who suffers from Angelman Syndrome
Colin Farrell shares a particularly tender moment with his eldest son, James, in the trailer for new documentary 'The Slightest Touch'. The 50-year-old Irish actor welcomed 23-year-old James with ex-partner Kim Bordenav. As an infant, James was diagnosed with Angelman syndrome, a rare genetic disorder that affects the nervous system, causing speech and movement difficulties and seizures. In the trailer released by HBO, Colin Farrell sits next to his son during an interview.
247bulletin.news
November 3, 2026 at 11:50 PM
Qué bonito que el documental ponga el foco en James con tanta naturalidad; ojalá sirva para dar más visibilidad al síndrome de Angelman.
November 2, 2026 at 7:28 AM
Rare public appearance for Colin Farrell's son in trailer for moving new film

The Irish actor's son James, 23, who has Angelman syndrome, appears in the trailer for his upcoming HBO documentary, The Slightest Touch
Colin Farrell's son makes rare appearance in new documentary
The Irish actor's son James, 23, who has Angelman syndrome, appears in the trailer for his upcoming HBO documentary, The Slightest Touch
www.irishmirror.ie
October 31, 2026 at 10:44 PM
Brain Stress Response is Key to #AngelmanSyndrome Symptoms

Reducing levels of an enzyme linked to the single gene mutation in Angelman syndrome restored brain size and normalized specific behaviors in mice.
#Neuroscience
Brain Stress Response is Key to Angelman Syndrome Symptoms | The Scientist
Reducing levels of an enzyme linked to the single gene mutation in Angelman syndrome restored brain size and normalized specific behaviors in mice.
www.the-scientist.com
October 29, 2026 at 8:35 PM
Colin Farrell mostró por primera vez a James, su hijo de 23 años que padece síndrome de Angelman
Colin Farrell mostró por primera vez a James, su hijo de 23 años que padece síndrome de Angelman
El actor irlandés aparece junto a James, de 23 años, en un documental sobre Emma Fogarty.
radiomitre.cienradios.com
November 1, 2026 at 3:35 PM
Colin Farrell mostró por primera vez a James, su hijo de 23 años que padece síndrome de Angelman
Colin Farrell mostró por primera vez a James, su hijo de 23 años que padece síndrome de Angelman
El actor irlandés aparece junto a James, de 23 años, en un documental sobre Emma Fogarty.
radiomitre.cienradios.com
November 1, 2026 at 3:35 PM